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INTERGROWTH-21st Pr...
INTERGROWTH-21st Project international INTER-NDA standards for child development at 2 years of age : an international prospective population-based study
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Fernandes, Michelle (author)
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Villar, José (author)
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Stein, Alan (author)
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Staines Urias, Eleonora (author)
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Garza, Cutberto (author)
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Victora, Cesar G. (author)
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Barros, Fernando C. (author)
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Bertino, Enrico (author)
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Purwar, Manorama (author)
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Carvalho, Maria (author)
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Giuliani, Francesca (author)
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- Wulff, Katharina (author)
- Umeå universitet,Diagnostisk radiologi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)
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Abubakar, Amina A. (author)
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Kihara, Michael (author)
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Cheikh Ismail, Leila (author)
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Aranzeta, Luis (author)
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Albernaz, Elaine (author)
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Kunnawar, Naina (author)
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Di Nicola, Paola (author)
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Ochieng, Roseline (author)
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Sandells, Tamsin (author)
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Savini, Sandy (author)
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Temple, Sophie (author)
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Murray, Elizabeth (author)
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Ohuma, Eric O. (author)
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Gravett, Michael G. (author)
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Pang, Ruyan (author)
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Jaffer, Yasmine A. (author)
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Noble, Julia Alison (author)
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Winsey, Adele (author)
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Lambert, Ann (author)
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Papageorghiou, Aris T. (author)
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Bhutta, Zulfiqar (author)
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Kennedy, Stephen (author)
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(creator_code:org_t)
- 2020-06-07
- 2020
- English.
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In: BMJ Open. - : BMJ Publishing Group Ltd. - 2044-6055. ; 10:6
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://bmjopen.bmj....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Objectives: To describe the construction of the international INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) standards for child development at 2 years by reporting the cognitive, language, motor and behaviour outcomes in optimally healthy and nourished children in the INTERGROWTH-21st Project.Design: Population-based cohort study, the INTERGROWTH-21st Project.Setting: Brazil, India, Italy, Kenya and the UK.Participants: 1181 children prospectively recruited from early fetal life according to the prescriptive WHO approach, and confirmed to be at low risk of adverse perinatal and postnatal outcomes.Primary measures: Scaled INTER-NDA domain scores for cognition, language, fine and gross motor skills and behaviour; vision outcomes measured on the Cardiff tests; attentional problems and emotional reactivity measured on the respective subscales of the preschool Child Behaviour Checklist; and the age of acquisition of the WHO gross motor milestones.Results: Scaled INTER-NDA domain scores are presented as centiles, which were constructed according to the prescriptive WHO approach and excluded children born preterm and those with significant postnatal/neurological morbidity. For all domains, except negative behaviour, higher scores reflect better outcomes and the threshold for normality was defined as >= 10th centile. For the INTER-NDA's cognitive, fine motor, gross motor, language and positive behaviour domains these are >= 38.5, >= 25.7, >= 51.7, >= 17.8 and >= 51.4, respectively. The threshold for normality for the INTER-NDA's negative behaviour domain is <= 50.0, that is, <= 90th centile. At 22-30 months of age, the cohort overlapped with the WHO motor milestone centiles, showed low postnatal morbidity (<10%), and vision outcomes, attentional problems and emotional reactivity scores within the respective normative ranges.Conclusions: From this large, healthy and well-nourished, international cohort, we have constructed, using the WHO prescriptive methodology, international INTER-NDA standards for child development at 2 years of age. Standards, rather than references, are recommended for population-level screening and the identification of children at risk of adverse outcomes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- community child health
- developmental neurology & neurodisability
- paediatrics
- epidemiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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Fernandes, Miche ...
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Villar, José
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Stein, Alan
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Staines Urias, E ...
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Garza, Cutberto
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Victora, Cesar G ...
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show more...
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Barros, Fernando ...
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Bertino, Enrico
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Purwar, Manorama
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Carvalho, Maria
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Giuliani, France ...
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Wulff, Katharina
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Abubakar, Amina ...
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Kihara, Michael
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Cheikh Ismail, L ...
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Aranzeta, Luis
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Albernaz, Elaine
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Kunnawar, Naina
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Di Nicola, Paola
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Ochieng, Roselin ...
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Sandells, Tamsin
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Savini, Sandy
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Temple, Sophie
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Murray, Elizabet ...
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Ohuma, Eric O.
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Gravett, Michael ...
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Pang, Ruyan
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Jaffer, Yasmine ...
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Noble, Julia Ali ...
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Winsey, Adele
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Lambert, Ann
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Papageorghiou, A ...
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Bhutta, Zulfiqar
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Kennedy, Stephen
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
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BMJ Open
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Umeå University