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Forecasting memory function in aging : pattern-completion ability and hippocampal activity relate to visuospatial functioning over 25 years
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- Nyberg, Lars, 1966- (author)
- Umeå University,Umeå universitet,Diagnostisk radiologi,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI),UiO Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
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- Grande, Xenia (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn,Otto von Guericke University Magdeburg
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- Andersson, Micael (author)
- Umeå University,Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)
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- (creator_code:org_t)
- Elsevier, 2020
- 2020
- English.
- In: Neurobiology of Aging. - : Elsevier. - 0197-4580 .- 1558-1497. ; 94, s. 217-226
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Heterogeneity in episodic memory functioning in aging was assessed with a pattern-completion functional magnetic resonance imaging task that required reactivation of well-consolidated face-name memory traces from fragmented (partial) or morphed (noisy) face cues. About half of the examined individuals (N = 101) showed impaired (chance) performance on fragmented faces despite intact performance on complete and morphed faces, and they did not show a pattern-completion response in hippocampus or the examined subfields (CA1, CA23, DGCA4). This apparent pattern-completion deficit could not be explained by differential hippocampal atrophy. Instead, the impaired group displayed lower cortical volumes, accelerated reduction in mini-mental state examination scores, and lower general cognitive function as defined by longitudinal measures of visuospatial functioning and speed-of-processing. In the full sample, inter-individual differences in visuospatial functioning predicted performance on fragmented faces and hippocampal CA23 subfield activity over 25 years. These findings suggest that visuospatial functioning in middle age can forecast pattern-completion deficits in aging.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Episodic memory
- General cognitive function
- Hippocampus
- Subfields
- Episodic memory
- General cognitive function
- Hippocampus
- Subfields
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- ref (subject category)
- art (subject category)
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