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  • Gorbach, Tetiana,1991-Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI) (author)

Longitudinal association between hippocampus atrophy and episodic-memory decline in non-demented APOE ε4 carriers

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-09-28
  • John Wiley & Sons,2020
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-175957
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-175957URI
  • https://doi.org/10.1002/dad2.12110DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Introduction: The apolipoprotein E (APOE) ε4 allele is the main genetic risk factor for Alzheimer's disease (AD), accelerated cognitive aging, and hippocampal atrophy, but its influence on the association between hippocampus atrophy and episodic-memory decline in non-demented individuals remains unclear.Methods: We analyzed longitudinal (two to six observations) magnetic resonance imaging (MRI)–derived hippocampal volumes and episodic memory from 748 individuals (55 to 90 years at baseline, 50% female) from the European Lifebrain consortium.Results: The change-change association for hippocampal volume and memory was significant only in ε4 carriers (N = 173, r = 0.21, P = .007; non-carriers: N = 467, r = 0.073,P = .117). The linear relationship was significantly steeper for the carriers [t(629) =2.4, P = .013]. A similar trend toward a stronger change-change relation for carriers was seen in a subsample with more than two assessments.Discussion: These findings provide evidence for a difference in hippocampus-memory association between ε4 carriers and non-carriers, thus highlighting how genetic factors modulate the translation of the AD-related pathophysiological cascade into cognitive deficits.

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  • Pudas, Sara,Fil. Dr.1983-Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)(Swepub:umu)saatus02 (author)
  • Bartrés-Faz, David (author)
  • Brandmaier, Andreas M.Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany (author)
  • Düzel, SandraCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany (author)
  • Henson, Richard N.MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK (author)
  • Idland, Ane-VictoriaOslo Delirium Research Group, Department of Geriatric Medicine, University of Oslo,Oslo, Norway (author)
  • Lindenberger, UlmanCenter for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany (author)
  • Macià Bros, DídacDepartment of Medicine, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain (author)
  • Mowinckel, Athanasia M.Center for Lifespan Changes in Brain and Cognition, University of Oslo,Oslo, Norway (author)
  • Solé-Padullés, CristinaDepartment of Medicine, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain (author)
  • Sørensen, ØysteinCenter for Lifespan Changes in Brain and Cognition, University of Oslo,Oslo, Norway (author)
  • Walhovd, Kristine B.Center for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway (author)
  • Watne, Leiv OttoMRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK (author)
  • Westerhausen, RenéCenter for Lifespan Changes in Brain and Cognition, University of Oslo,Oslo, Norway (author)
  • Fjell, Anders M.Center for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway (author)
  • Nyberg, Lars,1966-Umeå universitet,Diagnostisk radiologi,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)(Swepub:umu)lany0001 (author)
  • Umeå universitetInstitutionen för integrativ medicinsk biologi (IMB) (creator_code:org_t)

Related titles

  • In:Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring: John Wiley & Sons12:12352-8729

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