Search: onr:"swepub:oai:DiVA.org:umu-176312" >
Topologically selec...
Topologically selective islet vulnerability and self-sustained downregulation of markers for β-cell maturity in streptozotocin-induced diabetes
-
- Hahn, Max (author)
- Umeå universitet,Umeå centrum för molekylär medicin (UCMM)
-
van Krieken, Pim P. (author)
-
- Nord, Christoffer (author)
- Umeå universitet,Umeå centrum för molekylär medicin (UCMM)
-
show more...
-
- Alanentalo, Tomas (author)
- Umeå universitet,Umeå centrum för molekylär medicin (UCMM)
-
- Morini, Federico (author)
- Umeå universitet,Umeå centrum för molekylär medicin (UCMM)
-
- Xiong, Yan (author)
- Karolinska Institutet
-
- Eriksson, Maria (author)
- Umeå universitet,Umeå centrum för molekylär medicin (UCMM)
-
Mayer, Jurgen (author)
-
- Kostromina, Elena (author)
- Umeå universitet,Umeå centrum för molekylär medicin (UCMM)
-
- Ruas, Jorge L. (author)
- Karolinska Institutet
-
Sharpe, James (author)
-
Pereira, Teresa (author)
-
- Berggren, Per-Olof (author)
- Karolinska Institutet
-
- Ilegems, Erwin (author)
- Karolinska Institutet
-
- Ahlgren, Ulf (author)
- Umeå universitet,Umeå centrum för molekylär medicin (UCMM)
-
show less...
-
(creator_code:org_t)
- 2020-09-30
- 2020
- English.
-
In: Communications Biology. - : Nature Publishing Group. - 2399-3642. ; 3:1
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://umu.diva-por... (primary) (Raw object)
-
https://www.nature.c...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Mouse models of Streptozotocin (STZ) induced diabetes represent the most widely used preclinical diabetes research systems. We applied state of the art optical imaging schemes, spanning from single islet resolution to the whole organ, providing a first longitudinal, 3D-spatial and quantitative account of β-cell mass (BCM) dynamics and islet longevity in STZ-treated mice. We demonstrate that STZ-induced β-cell destruction predominantly affects large islets in the pancreatic core. Further, we show that hyperglycemic STZ-treated mice still harbor a large pool of remaining β-cells but display pancreas-wide downregulation of glucose transporter type 2 (GLUT2). Islet gene expression studies confirmed this downregulation and revealed impaired β-cell maturity. Reversing hyperglycemia by islet transplantation partially restored the expression of markers for islet function, but not BCM. Jointly our results indicate that STZ-induced hyperglycemia results from β-cell dysfunction rather than β-cell ablation and that hyperglycemia in itself sustains a negative feedback loop restraining islet function recovery.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Hahn, Max
-
van Krieken, Pim ...
-
Nord, Christoffe ...
-
Alanentalo, Toma ...
-
Morini, Federico
-
Xiong, Yan
-
show more...
-
Eriksson, Maria
-
Mayer, Jurgen
-
Kostromina, Elen ...
-
Ruas, Jorge L.
-
Sharpe, James
-
Pereira, Teresa
-
Berggren, Per-Ol ...
-
Ilegems, Erwin
-
Ahlgren, Ulf
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Cell Biology
- Articles in the publication
-
Communications B ...
- By the university
-
Umeå University
-
Karolinska Institutet