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Vitamin D, liver-related biomarkers, and distribution of fat and lean mass in young patients with Fontan circulation

Hansson, Lena, 1967- (author)
Umeå universitet,Pediatrik
Sandberg, Camilla (author)
Umeå universitet,Avdelningen för fysioterapi,Avdelningen för medicin
Öhlund, Inger, 1954- (author)
Umeå universitet,Pediatrik
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Lind, Torbjörn, 1966- (author)
Umeå universitet,Pediatrik
Sthen Bergdahl, Magne (author)
Umeå universitet,Pediatrik
Wiklund, Urban (author)
Umeå universitet,Radiofysik
Rylander Hedlund, Eva (author)
Karolinska Institutet
Sjöberg, Gunnar (author)
Karolinska Institutet
Rydberg, Annika (author)
Umeå universitet,Pediatrik
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 (creator_code:org_t)
Cambridge University Press, 2022
2022
English.
In: Cardiology in the Young. - : Cambridge University Press. - 1047-9511 .- 1467-1107. ; 32:6, s. 861-868
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Introduction/aim: Young patients with Fontan circulation may have low serum 25-hydroxyvitamin D levels, an affected liver, and unhealthy body compositions. This study aimed to explore the association between vitamin D intake/levels, liver biomarkers, and body composition in young Fontan patients.Method: We collected prospective data in 2017 to 2018, obtained with food-frequency questionnaires, biochemical analyses of liver biomarkers, and dual-energy X-ray absorptiometry scans in 44 children with Fontan circulation. Body compositions were compared to matched controls (n = 38). Linear regression analyses were used to investigate associations of biomarkers, leg pain, and lean mass on serum levels of 25-hydroxyvitamin D. Biomarkers were converted to z scores and differences were evaluated within the Fontan patients.Results: Our Fontan patients had a daily mean vitamin D intake of 9.9 µg and a mean serum 25-hydroxyvitamin D of 56 nmol/L. These factors were not associated with fat or lean mass, leg pain, or biomarkers of liver status. The Fontan patients had significantly less lean mass, but higher fat mass than controls. Male adolescents with Fontan circulation had a greater mean abdominal fat mass than male controls and higher cholesterol levels than females with Fontan circulation.Conclusion: Vitamin D intake and serum levels were not associated with body composition or liver biomarkers in the Fontan group, but the Fontan group had lower lean mass and higher fat mass than controls. The more pronounced abdominal fat mass in male adolescents with Fontan circulation might increase metabolic risks later in life.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Pediatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Pediatrics (hsv//eng)

Keyword

CHD
Fontan circulation
vitamin D
micronutrient intake
body composition
Pediatrics
pediatrik

Publication and Content Type

ref (subject category)
art (subject category)

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