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  • Hansson, Lena,1967-Umeå universitet,Pediatrik (author)

Vitamin D, liver-related biomarkers, and distribution of fat and lean mass in young patients with Fontan circulation

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • Cambridge University Press,2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-176573
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-176573URI
  • https://doi.org/10.1017/S1047951121003115DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:148732439URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Originally included in thesis in manuscript form.
  • Introduction/aim: Young patients with Fontan circulation may have low serum 25-hydroxyvitamin D levels, an affected liver, and unhealthy body compositions. This study aimed to explore the association between vitamin D intake/levels, liver biomarkers, and body composition in young Fontan patients.Method: We collected prospective data in 2017 to 2018, obtained with food-frequency questionnaires, biochemical analyses of liver biomarkers, and dual-energy X-ray absorptiometry scans in 44 children with Fontan circulation. Body compositions were compared to matched controls (n = 38). Linear regression analyses were used to investigate associations of biomarkers, leg pain, and lean mass on serum levels of 25-hydroxyvitamin D. Biomarkers were converted to z scores and differences were evaluated within the Fontan patients.Results: Our Fontan patients had a daily mean vitamin D intake of 9.9 µg and a mean serum 25-hydroxyvitamin D of 56 nmol/L. These factors were not associated with fat or lean mass, leg pain, or biomarkers of liver status. The Fontan patients had significantly less lean mass, but higher fat mass than controls. Male adolescents with Fontan circulation had a greater mean abdominal fat mass than male controls and higher cholesterol levels than females with Fontan circulation.Conclusion: Vitamin D intake and serum levels were not associated with body composition or liver biomarkers in the Fontan group, but the Fontan group had lower lean mass and higher fat mass than controls. The more pronounced abdominal fat mass in male adolescents with Fontan circulation might increase metabolic risks later in life.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Sandberg, CamillaUmeå universitet,Avdelningen för fysioterapi,Avdelningen för medicin(Swepub:umu)caahom90 (author)
  • Öhlund, Inger,1954-Umeå universitet,Pediatrik(Swepub:umu)inrlid73 (author)
  • Lind, Torbjörn,1966-Umeå universitet,Pediatrik(Swepub:umu)toli0008 (author)
  • Sthen Bergdahl, MagneUmeå universitet,Pediatrik (author)
  • Wiklund, UrbanUmeå universitet,Radiofysik(Swepub:umu)urwi0001 (author)
  • Rylander Hedlund, EvaKarolinska Institutet (author)
  • Sjöberg, GunnarKarolinska Institutet (author)
  • Rydberg, AnnikaUmeå universitet,Pediatrik(Swepub:umu)anry0014 (author)
  • Umeå universitetPediatrik (creator_code:org_t)

Related titles

  • In:Cardiology in the Young: Cambridge University Press32:6, s. 861-8681047-95111467-1107

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