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Validation of a UPD...
Validation of a UPDRS-/MDS-UPDRS-based definition of functional dependency for Parkinson's disease
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Ramsay, Neil (author)
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Macleod, Angus D. (author)
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Alves, Guido (author)
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Camacho, Marta (author)
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- Forsgren, Lars (author)
- Umeå universitet,Neurovetenskaper
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Lawson, Rachael A. (author)
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Maple-Grødem, Jodi (author)
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Tysnes, Ole-Bjørn (author)
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Williams-Gray, Caroline H. (author)
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Yarnall, Alison J. (author)
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Counsell, Carl E. (author)
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(creator_code:org_t)
- Elsevier, 2020
- 2020
- English.
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In: Parkinsonism & Related Disorders. - : Elsevier. - 1353-8020 .- 1873-5126. ; 76, s. 49-53
- Related links:
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https://aura.abdn.ac...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- INTRODUCTION: Functional dependency in basic activities of daily living (ADLs) is a key outcome in Parkinson's disease (PD). We aimed to define dependency in PD, using the original and MDS versions of the Unified Parkinson's Disease Rating Scale (UPDRS).METHODS: We developed two algorithms to define dependency from items of UPDRS Part 2 and MDS-UPDRS Part 2 relating to basic ADLs (feeding, dressing, hygiene and walking, and getting out of a chair). We validated both algorithms using data from 1110 patients from six community-based PD incidence cohorts, testing concurrent validity, convergent validity, and predictive validity.RESULTS: Our optimal algorithm showed high specificity and moderate to high sensitivity versus Schwab & England <80% (specificity 95% [95% confidence interval (CI) 93-97] and sensitivity 65% [95% CI 55-73] at baseline; 88% [95% CI 85-91] and 85% [95% CI 79-97] respectively at five-years follow-up). Convergent validity was demonstrated by strong associations between dependency defined by the algorithm and cognition (MMSE), quality of life (PDQ39), and impairment (UPDRS part 3) (all p < 0.001). Algorithm-defined dependency status also predicted mortality: HR for mortality in those dependent vs independent at baseline was 1.6 (95%CI 1.2-2.1) and in those dependent vs independent at five-years' follow-up was 2.2 (1.6-3.0).DISCUSSION: We have demonstrated the concurrent validity, convergent validity, and predictive validity of a UPDRS-/MDS-UPDRS-based algorithm to define functional dependency in PD. This can be used for studying dependency in any study where UPDRS or MDS-UPDRS part 2 data have been collected.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Dependency
- Measurement scales
- Parkinson's disease
- Validation
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ramsay, Neil
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Macleod, Angus D ...
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Alves, Guido
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Camacho, Marta
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Forsgren, Lars
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Lawson, Rachael ...
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show more...
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Maple-Grødem, Jo ...
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Tysnes, Ole-Bjør ...
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Williams-Gray, C ...
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Yarnall, Alison ...
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Counsell, Carl E ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Parkinsonism & R ...
- By the university
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Umeå University