Search: onr:"swepub:oai:DiVA.org:umu-176816" >
Intake of Dietary F...
Intake of Dietary Fruit, Vegetables, and Fiber and Risk of Colorectal Cancer According to Molecular Subtypes : A Pooled Analysis of 9 Studies
- Article/chapterEnglish2020
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:DiVA.org:umu-176816
-
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-176816URI
-
https://doi.org/10.1158/0008-5472.CAN-20-0168DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Protective associations of fruits, vegetables, and fiber intake with colorectal cancer risk have been shown in many, but not all epidemiologic studies. One possible reason for study heterogeneity is that dietary factors may have distinct effects by colorectal cancer molecular subtypes. Here, we investigate the association of fruit, vegetables, and fiber intake with four well-established colorectal cancer molecular subtypes separately and in combination. Nine observational studies including 9,592 cases with molecular subtypes for microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and somatic mutations in BRAF and KRAS genes, and 7,869 controls were analyzed. Both case-only logistic regression analyses and polytomous logistic regression analyses (with one control set and multiple case groups) were used. Higher fruit intake was associated with a trend toward decreased risk of BRAF-mutated tumors [OR 4th vs. 1st quartile = 0.82 (95% confidence interval, 0.65–1.04)] but not BRAF-wildtype tumors [1.09 (0.97–1.22); P difference as shown in case-only analysis = 0.02]. This difference was observed in case–control studies and not in cohort studies. Compared with controls, higher fiber intake showed negative association with colorectal cancer risk for cases with microsatellite stable/MSI-low, CIMP-negative, BRAF-wildtype, and KRAS-wildtype tumors (Ptrend range from 0.03 to 3.4e-03), which is consistent with the traditional adenoma-colorectal cancer pathway. These negative associations were stronger compared with MSI-high, CIMP-positive, BRAF-mutated, or KRAS-mutated tumors, but the differences were not statistically significant. These inverse associations for fruit and fiber intake may explain, in part, inconsistent findings between fruit or fiber intake and colorectal cancer risk that have previously been reported.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Harrison, Tabitha A.
(author)
-
Cao, Yin
(author)
-
Sakoda, Lori C.
(author)
-
Barfield, Richard
(author)
-
Giannakis, Marios
(author)
-
Song, Mingyang
(author)
-
Phipps, Amanda, I
(author)
-
Figueiredo, Jane C.
(author)
-
Zaidi, Syed H.
(author)
-
Toland, Amanda E.
(author)
-
Amitay, Efrat L.
(author)
-
Berndt, Sonja, I
(author)
-
Borozan, Ivan
(author)
-
Chan, Andrew T.
(author)
-
Gallinger, Steven
(author)
-
Gunter, Marc J.
(author)
-
Guinter, Mark A.
(author)
-
Harlid, Sophia,1978-Umeå universitet,Onkologi(Swepub:umu)soha0105
(author)
-
Hampel, Heather
(author)
-
Jenkins, Mark A.
(author)
-
Lin, Yi
(author)
-
Moreno, Victor
(author)
-
Newcomb, Polly A.
(author)
-
Nishihara, Reiko
(author)
-
Ogino, Shuji
(author)
-
Obon-Santacana, Mireia
(author)
-
Parfrey, Patrick S.
(author)
-
Potter, John D.
(author)
-
Slattery, Martha L.
(author)
-
Steinfelder, Robert S.
(author)
-
Um, Caroline Y.
(author)
-
Wang, Xiaoliang
(author)
-
Woods, Michael O.
(author)
-
van Guelpen, BethanyUmeå universitet,Onkologi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)(Swepub:umu)beyvan99
(author)
-
Thibodeau, Stephen N.
(author)
-
Hoffmeister, Michael
(author)
-
Sun, Wei
(author)
-
Hsu, Li
(author)
-
Buchanan, Daniel D.
(author)
-
Campbell, Peter T.
(author)
-
Peters, Ulrike
(author)
-
Umeå universitetOnkologi
(creator_code:org_t)
Related titles
-
In:Cancer Research80:20, s. 4578-45900008-54721538-7445
Internet link
Find in a library
To the university's database
- By the author/editor
-
Hidaka, Akihisa
-
Harrison, Tabith ...
-
Cao, Yin
-
Sakoda, Lori C.
-
Barfield, Richar ...
-
Giannakis, Mario ...
-
show more...
-
Song, Mingyang
-
Phipps, Amanda, ...
-
Figueiredo, Jane ...
-
Zaidi, Syed H.
-
Toland, Amanda E ...
-
Amitay, Efrat L.
-
Berndt, Sonja, I
-
Borozan, Ivan
-
Chan, Andrew T.
-
Gallinger, Steve ...
-
Gunter, Marc J.
-
Guinter, Mark A.
-
Harlid, Sophia, ...
-
Hampel, Heather
-
Jenkins, Mark A.
-
Lin, Yi
-
Moreno, Victor
-
Newcomb, Polly A ...
-
Nishihara, Reiko
-
Ogino, Shuji
-
Obon-Santacana, ...
-
Parfrey, Patrick ...
-
Potter, John D.
-
Slattery, Martha ...
-
Steinfelder, Rob ...
-
Um, Caroline Y.
-
Wang, Xiaoliang
-
Woods, Michael O ...
-
van Guelpen, Bet ...
-
Thibodeau, Steph ...
-
Hoffmeister, Mic ...
-
Sun, Wei
-
Hsu, Li
-
Buchanan, Daniel ...
-
Campbell, Peter ...
-
Peters, Ulrike
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Cancer Research
- By the university
-
Umeå University