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  • Magalhaes, IsabelleKarolinska Institutet (author)

Facing the future : challenges and opportunities in adoptive T cell therapy in cancer

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-04-30
  • Taylor & Francis Group,2019
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-177335
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-177335URI
  • https://doi.org/10.1080/14712598.2019.1608179DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:230986360URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • INTRODUCTION: In recent years, immunotherapy for the treatment of solid cancer has emerged as a promising therapeutic alternative. Adoptive cell therapy (ACT), especially T cell-based, has been found to cause tumor regression and even cure in a percentage of treated patients. Checkpoint inhibitors further underscore the potential of the T cell compartment in the treatment of cancer. Not all patients respond to these treatments; however, many challenges remain.AREAS COVERED: This review covers the challenges and progress in tumor antigen target identification and selection, and cell product manufacturing for T cell ACT. Tumor immune escape mechanisms and strategies to overcome those in the context of T cell ACT are also discussed.EXPERT OPINION: The immunotherapy toolbox is rapidly expanding and improving, and the future promises further breakthroughs in the T cell ACT field. The heterogeneity of the tumor microenvironment and the multiplicity of tumor immune escape mechanisms pose formidable challenges to successful T cell immunotherapy in solid tumors, however. Individualized approaches and strategies combining treatments targeting different immunotherapeutic aspects will be needed in order to expand the applicability and improve the response rates in future.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Carvalho-Queiroz, Claudia (author)
  • Hartana, Ciputra Adijaya (author)
  • Kaiser, Andreas (author)
  • Lukic, AnaKarolinska Institutet (author)
  • Mints, MichaelKarolinska Institutet,Umeå universitet,Urologi och andrologi(Swepub:umu)mimi0028 (author)
  • Nilsson, Ola (author)
  • Grönlund, HansKarolinska Institutet (author)
  • Mattsson, JonasKarolinska Institutet (author)
  • Berglund, SofiaKarolinska Institutet (author)
  • Karolinska InstitutetUrologi och andrologi (creator_code:org_t)

Related titles

  • In:Expert Opinion on Biological Therapy: Taylor & Francis Group19:8, s. 811-8271471-25981744-7682

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