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Interethnic analyse...
Interethnic analyses of blood pressure loci in populations of East Asian and European descent
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Takeuchi, Fumihiko (author)
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Akiyama, Masato (author)
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Matoba, Nana (author)
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Katsuya, Tomohiro (author)
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Nakatochi, Masahiro (author)
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Tabara, Yasuharu (author)
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Narita, Akira (author)
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Saw, Woei-Yuh (author)
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Moon, Sanghoon (author)
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Spracklen, Cassandra N. (author)
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Chai, Jin-Fang (author)
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Kim, Young-Jin (author)
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Zhang, Liang (author)
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Wang, Chaolong (author)
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Li, Huaixing (author)
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Li, Honglan (author)
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Wu, Jer-Yuarn (author)
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Dorajoo, Rajkumar (author)
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Nierenberg, Jovia L. (author)
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Wang, Ya Xing (author)
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He, Jing (author)
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Bennett, Derrick A. (author)
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Takahashi, Atsushi (author)
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Momozawa, Yukihide (author)
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Hirata, Makoto (author)
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Matsuda, Koichi (author)
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Rakugi, Hiromi (author)
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Nakashima, Eitaro (author)
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Isono, Masato (author)
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Shirota, Matsuyuki (author)
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Hozawa, Atsushi (author)
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Ichihara, Sahoko (author)
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Matsubara, Tatsuaki (author)
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Yamamoto, Ken (author)
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Kohara, Katsuhiko (author)
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Igase, Michiya (author)
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Han, Sohee (author)
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Gordon-Larsen, Penny (author)
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Huang, Wei (author)
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Lee, Nanette R. (author)
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Adair, Linda S. (author)
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Hwang, Mi Yeong (author)
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Lee, Juyoung (author)
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Chee, Miao Li (author)
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Sabanayagam, Charumathi (author)
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Zhao, Wanting (author)
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Liu, Jianjun (author)
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Reilly, Dermot F. (author)
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Sun, Liang (author)
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Huo, Shaofeng (author)
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Edwards, Todd L. (author)
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Long, Jirong (author)
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Chang, Li-Ching (author)
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Chen, Chien-Hsiun (author)
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Yuan, Jian-Min (author)
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Koh, Woon-Puay (author)
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Friedlander, Yechiel (author)
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Kelly, Tanika N. (author)
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Bin Wei, Wen (author)
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Xu, Liang (author)
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Cai, Hui (author)
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Xiang, Yong-Bing (author)
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Lin, Kuang (author)
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Clarke, Robert (author)
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Walters, Robin G. (author)
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Millwood, Iona Y. (author)
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Li, Liming (author)
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Chambers, John C. (author)
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Kooner, Jaspal S. (author)
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Elliott, Paul (author)
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van der Harst, Pim (author)
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Chen, Zhengming (author)
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Sasaki, Makoto (author)
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Shu, Xiao-Ou (author)
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Jonas, Jost B. (author)
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He, Jiang (author)
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Heng, Chew-Kiat (author)
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Chen, Yuan-Tsong (author)
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Zheng, Wei (author)
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Lin, Xu (author)
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Teo, Yik-Ying (author)
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Tai, E-Shyong (author)
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Cheng, Ching-Yu (author)
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Wong, Tien Yin (author)
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Sim, Xueling (author)
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Mohlke, Karen L. (author)
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Yamamoto, Masayuki (author)
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Kim, Bong-Jo (author)
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Miki, Tetsuro (author)
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Nabika, Toru (author)
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Yokota, Mitsuhiro (author)
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Kamatani, Yoichiro (author)
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Kubo, Michiaki (author)
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Kato, Norihiro (author)
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- Rolandsson, Olov (contributor)
- Umeå universitet,Allmänmedicin,The International Genomics of Blood Pressure (iGEN-BP) Consortium
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- Franks, Paul W. (contributor)
- Umeå universitet,Allmänmedicin,The International Genomics of Blood Pressure (iGEN-BP) Consortium; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital, Malmö, Sweden; Department of Nutrition, Harvard School of Public Health, Boston, USA
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(creator_code:org_t)
- 2018-11-28
- 2018
- English.
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In: Nature Communications. - : Springer Nature. - 2041-1723. ; 9:1
- Related links:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Takeuchi, Fumihi ...
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Akiyama, Masato
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Matoba, Nana
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Katsuya, Tomohir ...
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Nakatochi, Masah ...
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Tabara, Yasuharu
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show more...
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Narita, Akira
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Saw, Woei-Yuh
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Moon, Sanghoon
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Spracklen, Cassa ...
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Chai, Jin-Fang
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Kim, Young-Jin
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Zhang, Liang
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Wang, Chaolong
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Li, Huaixing
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Li, Honglan
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Wu, Jer-Yuarn
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Dorajoo, Rajkuma ...
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Nierenberg, Jovi ...
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Wang, Ya Xing
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He, Jing
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Bennett, Derrick ...
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Takahashi, Atsus ...
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Momozawa, Yukihi ...
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Hirata, Makoto
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Matsuda, Koichi
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Rakugi, Hiromi
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Nakashima, Eitar ...
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Isono, Masato
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Shirota, Matsuyu ...
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Hozawa, Atsushi
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Ichihara, Sahoko
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Matsubara, Tatsu ...
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Yamamoto, Ken
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Kohara, Katsuhik ...
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Igase, Michiya
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Han, Sohee
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Gordon-Larsen, P ...
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Huang, Wei
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Lee, Nanette R.
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Adair, Linda S.
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Hwang, Mi Yeong
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Lee, Juyoung
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Chee, Miao Li
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Sabanayagam, Cha ...
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Zhao, Wanting
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Liu, Jianjun
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Reilly, Dermot F ...
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Sun, Liang
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Huo, Shaofeng
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Edwards, Todd L.
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Long, Jirong
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Chang, Li-Ching
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Chen, Chien-Hsiu ...
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Yuan, Jian-Min
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Koh, Woon-Puay
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Friedlander, Yec ...
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Kelly, Tanika N.
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Bin Wei, Wen
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Xu, Liang
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Cai, Hui
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Xiang, Yong-Bing
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Lin, Kuang
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Clarke, Robert
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Walters, Robin G ...
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Millwood, Iona Y ...
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Li, Liming
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Chambers, John C ...
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Kooner, Jaspal S ...
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Elliott, Paul
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van der Harst, P ...
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Chen, Zhengming
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Sasaki, Makoto
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Shu, Xiao-Ou
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Jonas, Jost B.
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He, Jiang
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Heng, Chew-Kiat
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Chen, Yuan-Tsong
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Zheng, Wei
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Lin, Xu
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Teo, Yik-Ying
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Tai, E-Shyong
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Cheng, Ching-Yu
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Wong, Tien Yin
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Sim, Xueling
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Mohlke, Karen L.
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Yamamoto, Masayu ...
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Kim, Bong-Jo
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Miki, Tetsuro
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Nabika, Toru
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Yokota, Mitsuhir ...
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Kamatani, Yoichi ...
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Kubo, Michiaki
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Kato, Norihiro
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Rolandsson, Olov
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Franks, Paul W.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Nature Communica ...
- By the university
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Umeå University