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Interethnic analyse...
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Takeuchi, Fumihiko
(author)
Interethnic analyses of blood pressure loci in populations of East Asian and European descent
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-11-28
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Springer Nature,2018
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-177962
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-177962URI
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https://doi.org/10.1038/s41467-018-07345-0DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Akiyama, Masato
(author)
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Matoba, Nana
(author)
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Katsuya, Tomohiro
(author)
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Nakatochi, Masahiro
(author)
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Tabara, Yasuharu
(author)
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Narita, Akira
(author)
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Saw, Woei-Yuh
(author)
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Moon, Sanghoon
(author)
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Spracklen, Cassandra N.
(author)
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Chai, Jin-Fang
(author)
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Kim, Young-Jin
(author)
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Zhang, Liang
(author)
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Wang, Chaolong
(author)
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Li, Huaixing
(author)
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Li, Honglan
(author)
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Wu, Jer-Yuarn
(author)
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Dorajoo, Rajkumar
(author)
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Nierenberg, Jovia L.
(author)
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Wang, Ya Xing
(author)
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He, Jing
(author)
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Bennett, Derrick A.
(author)
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Takahashi, Atsushi
(author)
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Momozawa, Yukihide
(author)
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Hirata, Makoto
(author)
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Matsuda, Koichi
(author)
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Rakugi, Hiromi
(author)
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Nakashima, Eitaro
(author)
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Isono, Masato
(author)
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Shirota, Matsuyuki
(author)
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Hozawa, Atsushi
(author)
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Ichihara, Sahoko
(author)
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Matsubara, Tatsuaki
(author)
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Yamamoto, Ken
(author)
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Kohara, Katsuhiko
(author)
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Igase, Michiya
(author)
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Han, Sohee
(author)
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Gordon-Larsen, Penny
(author)
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Huang, Wei
(author)
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Lee, Nanette R.
(author)
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Adair, Linda S.
(author)
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Hwang, Mi Yeong
(author)
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Lee, Juyoung
(author)
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Chee, Miao Li
(author)
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Sabanayagam, Charumathi
(author)
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Zhao, Wanting
(author)
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Liu, Jianjun
(author)
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Reilly, Dermot F.
(author)
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Sun, Liang
(author)
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Huo, Shaofeng
(author)
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Edwards, Todd L.
(author)
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Long, Jirong
(author)
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Chang, Li-Ching
(author)
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Chen, Chien-Hsiun
(author)
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Yuan, Jian-Min
(author)
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Koh, Woon-Puay
(author)
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Friedlander, Yechiel
(author)
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Kelly, Tanika N.
(author)
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Bin Wei, Wen
(author)
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Xu, Liang
(author)
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Cai, Hui
(author)
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Xiang, Yong-Bing
(author)
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Lin, Kuang
(author)
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Clarke, Robert
(author)
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Walters, Robin G.
(author)
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Millwood, Iona Y.
(author)
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Li, Liming
(author)
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Chambers, John C.
(author)
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Kooner, Jaspal S.
(author)
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Elliott, Paul
(author)
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van der Harst, Pim
(author)
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Chen, Zhengming
(author)
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Sasaki, Makoto
(author)
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Shu, Xiao-Ou
(author)
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Jonas, Jost B.
(author)
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He, Jiang
(author)
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Heng, Chew-Kiat
(author)
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Chen, Yuan-Tsong
(author)
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Zheng, Wei
(author)
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Lin, Xu
(author)
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Teo, Yik-Ying
(author)
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Tai, E-Shyong
(author)
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Cheng, Ching-Yu
(author)
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Wong, Tien Yin
(author)
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Sim, Xueling
(author)
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Mohlke, Karen L.
(author)
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Yamamoto, Masayuki
(author)
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Kim, Bong-Jo
(author)
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Miki, Tetsuro
(author)
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Nabika, Toru
(author)
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Yokota, Mitsuhiro
(author)
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Kamatani, Yoichiro
(author)
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Kubo, Michiaki
(author)
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Kato, Norihiro
(author)
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Rolandsson, OlovUmeå universitet,Allmänmedicin,The International Genomics of Blood Pressure (iGEN-BP) Consortium(Swepub:umu)olro0005
(contributor)
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Franks, Paul W.Umeå universitet,Allmänmedicin,The International Genomics of Blood Pressure (iGEN-BP) Consortium; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital, Malmö, Sweden; Department of Nutrition, Harvard School of Public Health, Boston, USA(Swepub:umu)pafr0003
(contributor)
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Umeå universitetAllmänmedicin
(creator_code:org_t)
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In:Nature Communications: Springer Nature9:12041-1723
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Takeuchi, Fumihi ...
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Akiyama, Masato
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Jonas, Jost B.
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Chen, Yuan-Tsong
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Zheng, Wei
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Lin, Xu
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Teo, Yik-Ying
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