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The intratumoral CX...
The intratumoral CXCR3 chemokine system is predictive of chemotherapy response in human bladder cancer
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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American Association for the Advancement of Science (AAAS),2021
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LIBRIS-ID:oai:DiVA.org:umu-178763
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-178763URI
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https://doi.org/10.1126/scitranslmed.abb3735DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Chemotherapy has direct toxic effects on cancer cells; however, long-term cancer control and complete remission are likely to involve CD8+ T cell immune responses. To study the role of CD8+ T cell infiltration in the success of chemotherapy, we examined patients with muscle invasive bladder cancer (MIBC) who were categorized on the basis of the response to neoadjuvant chemotherapy (NAC). We identified the intratumoral CXCR3 chemokine system (ligands and receptor splice variants) as a critical component for tumor eradication upon NAC in MIBC. Through characterization of CD8+ T cells, we found that stem-like T cell subpopulations with abundant CXCR3alt, a variant form of the CXCL11 receptor, responded to CXCL11 in culture as demonstrated by migration and enhanced effector function. In tumor biopsies of patients with MIBC accessed before treatment, CXCL11 abundance correlated with high numbers of tumor-infiltrating T cells and response to NAC. The presence of CXCR3alt and CXCL11 was associated with improved overall survival in MIBC. Evaluation of both CXCR3alt and CXCL11 enabled discrimination between responder and nonresponder patients with MIBC before treatment. We validated the prognostic role of the CXCR3-CXCL11 chemokine system in an independent cohort of chemotherapy-treated and chemotherapy-naïve patients with MIBC from data in TCGA. In summary, our data revealed stimulatory activity of the CXCR3alt-CXCL11 chemokine system on CD8+ T cells that is predictive of chemotherapy responsiveness in MIBC. This may offer immunotherapeutic options for targeted activation of intratumoral stem-like T cells in solid tumors.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Schlickeiser, Stephan
(author)
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Amini, Leila
(author)
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Schulenberg, Sarah
(author)
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Wendering, Desiree J.
(author)
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Banday, Viqar ShowkatUmeå universitet,Urologi och andrologi,Institutionen för klinisk mikrobiologi(Swepub:umu)vish0005
(author)
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Jurisch, Anke
(author)
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Noster, Rebecca
(author)
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Kunkel, Desiree
(author)
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Brindle, Nicola R.
(author)
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Savidis, Ioannis
(author)
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Akyüz, Levent
(author)
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Hecht, Jochen
(author)
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Stervbo, Ulrik
(author)
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Roch, Toralf
(author)
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Babel, Nina
(author)
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Reinke, Petra
(author)
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Winqvist, Ola
(author)
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Sherif, AmirUmeå universitet,Urologi och andrologi(Swepub:umu)amsh0008
(author)
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Volk, Hans-Dieter
(author)
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Schmueck-Henneresse, Michael
(author)
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Umeå universitetUrologi och andrologi
(creator_code:org_t)
Related titles
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In:Science Translational Medicine: American Association for the Advancement of Science (AAAS)13:5761946-62341946-6242
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Vollmer, Tino
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Schlickeiser, St ...
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Amini, Leila
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Schulenberg, Sar ...
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Wendering, Desir ...
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Banday, Viqar Sh ...
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show more...
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Jurisch, Anke
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Noster, Rebecca
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Kunkel, Desiree
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Brindle, Nicola ...
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Savidis, Ioannis
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Akyüz, Levent
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Hecht, Jochen
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Stervbo, Ulrik
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Roch, Toralf
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Babel, Nina
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Reinke, Petra
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Winqvist, Ola
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Sherif, Amir
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Volk, Hans-Diete ...
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Schmueck-Hennere ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
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Umeå University