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  • Kolmert, JohanKarolinska Institutet (author)

Urinary Leukotriene E-4 and Prostaglandin D-2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation A Clinical Observational Study

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • NEW YORK, USA :AMER THORACIC SOC,2021
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-179652
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-179652URI
  • https://doi.org/10.1164/rccm.201909-1869OCDOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-435151URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:145661963URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Rationale: New approaches are needed to guide personalized treatment of asthma. Objectives: To test if urinary eicosanoid metabolites can direct asthma phenotyping. Methods: Urinary metabolites of prostaglandins (PGs), cysteinyl leukotrienes (CysLTs), and isoprostanes were quantified in the U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Diseases Outcomes) study including 86 adults with mild-to-moderate asthma (MMA), 411 with severe asthma (SA), and 100 healthy control participants. Validation was performed internally in 302 participants with SA followed up after 12-18 months and externally in 95 adolescents with asthma. Measurement and Main Results: Metabolite concentrations in healthy control participants were unrelated to age, body mass index, and sex, except for the PGE(2) pathway. Eicosanoid concentrations were generally greater in participants with MMA relative to healthy control participants, with further elevations in participants with SA. However, PGE(2) metabolite concentrations were either the same or lower in male nonsmokers with asthma than in healthy control participants. Metabolite concentrations were unchanged in those with asthma who adhered to oral corticosteroid treatment as documented by urinary prednisolone detection, whereas those with SA treated with omalizumab had lower concentrations of LTE4 and the PGD(2) metabolite 2,3-dinor-11 beta-PGF(2 alpha). High concentrations of LTE4 and PGD(2) metabolites were associated with lower lung function and increased amounts of exhaled nitric oxide and eosinophil markers in blood, sputum, and urine in U-BIOARED participants and in adolescents with asthma. These type 2 (T2) asthma associations were reproduced in the follow-up visit of the U-BIOPRED study and were found to be as sensitive to detect T2 inflammation as the established biomarkers. Conclusions: Monitoring of urinary eicosanoids can identify T2 asthma and introduces a new noninvasive approach for molecular phenotyping of adult and adolescent asthma.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Gomez, CristinaKarolinska Inst, Inst Environm Med, Stockholm, Sweden.;Karolinska Inst, Div Physiol Chem 2, Dept Med Biochem & Biophys, Biomed Quarter 9A, S-17177 Stockholm, Sweden.;Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden. (author)
  • Balgoma, DavidKarolinska Inst, Inst Environm Med, Stockholm, Sweden.;Karolinska Inst, Div Physiol Chem 2, Dept Med Biochem & Biophys, Biomed Quarter 9A, S-17177 Stockholm, Sweden.;Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden. (author)
  • Sjodin, MarcusKarolinska Inst, Inst Environm Med, Stockholm, Sweden.;Karolinska Inst, Div Physiol Chem 2, Dept Med Biochem & Biophys, Biomed Quarter 9A, S-17177 Stockholm, Sweden.;Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden. (author)
  • Bood, JohanKarolinska Inst, Inst Environm Med, Stockholm, Sweden.;Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden.;Karolinska Inst, Dept Med, Huddinge Campus, Stockholm, Sweden. (author)
  • Konradsen, Jon R.Karolinska Institutet (author)
  • Ericsson, MagnusKarolinska Institutet (author)
  • Thorngren, John-OlofKarolinska Inst, Dept Clin Pharmacol, Huddinge Campus, Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm, Sweden. (author)
  • James, AnnaKarolinska Institutet (author)
  • Mikus, MariaKarolinska Institutet (author)
  • Sousa, Ana R.GlaxoSmithKline, London, England. (author)
  • Riley, John H.GlaxoSmithKline, London, England. (author)
  • Bates, StewartGlaxoSmithKline, London, England. (author)
  • Bakke, Per S.Univ Bergen, Inst Med, Bergen, Norway. (author)
  • Pandis, IoannisImperial Coll London, Natl Heart & Lung Inst, London, England.;Imperial Coll London, Dept Comp, London, England.;Imperial Coll London, Data Sci Inst, London, England. (author)
  • Caruso, MassimoUniv Catania, Dept Clin & Expt Med, Catania, Italy.;Univ Catania, Dept Biomed & Biotechnol Sci, Catania, Italy. (author)
  • Chanez, PascalAix Marseille Univ, AP HM, Clin Bronches Allergies & Sommeil, Marseille, France. (author)
  • Fowler, Stephen J.Univ Manchester, Fac Biol Med & Hlth, Sch Biol Sci, Div Infect Immun & Resp Med, Manchester, Lancs, England.;Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England.;Manchester Univ Hosp Natl Hlth Serv Fdn Trust, Natl Inst Hlth Res, Biomed Res Ctr, Manchester, Lancs, England. (author)
  • Geiser, ThomasUniv Hosp Bern, Dept Pulm Med, Bern, Switzerland. (author)
  • Howarth, PeterSouthampton Univ, Fac Med, Southampton, Hants, England.;Univ Hosp Southampton, Biomed Res Ctr, Natl Inst Hlth Res, Southampton Resp Biomed Res Ctr, Southampton, Hants, England. (author)
  • Horvath, IldikoSemmelweis Univ, Dept Pulmonol, Budapest, Hungary. (author)
  • Krug, NorbertFraunhofer Inst Toxicol & Expt Med, Hannover, Germany. (author)
  • Montuschi, PaoloUniv Cattolica Sacro Cuore, Dept Pharmacol, Rome, Italy.;IRCCS, Agostino Gemelli Univ Hosp Fdn, Rome, Italy. (author)
  • Sanak, MarekJagiellonian Univ, Med Coll, Dept Internal Med, Krakow, Poland. (author)
  • Behndig, Annelie F.,1963-Umeå universitet,Avdelningen för medicin,Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden.(Swepub:umu)anbe0145 (author)
  • Shaw, Dominick E.Univ Nottingham, Nottingham Natl Inst Hlth Res, Biomed Res Ctr, Nottingham, England. (author)
  • Knowles, Richard G.Knowles Consulting, Stevenage Biosci Catalyst, Stevenage, Herts, England. (author)
  • Holweg, Cecile T. J.Genentech Inc, S San Fransisco, CA USA. (author)
  • Wheelock, Asa M. (author)
  • Dahlen, BarbroKarolinska Institutet (author)
  • Nordlund, BjornKarolinska Institutet (author)
  • Alving, Kjell,1959-Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa(Swepub:uu)kjeal631 (author)
  • Hedlin, GunillaKarolinska Institutet (author)
  • Chung, Kian FanImperial Coll London, Natl Heart & Lung Inst, London, England.;Imperial Coll London, Dept Comp, London, England.;Imperial Coll London, Data Sci Inst, London, England. (author)
  • Adcock, Ian M. (author)
  • Sterk, Peter J.Univ Amsterdam, Amsterdam Univ Med Ctr, Dept Resp Med, Amsterdam, Netherlands. (author)
  • Djukanovic, RatkoSouthampton Univ, Fac Med, Southampton, Hants, England.;Univ Hosp Southampton, Biomed Res Ctr, Natl Inst Hlth Res, Southampton Resp Biomed Res Ctr, Southampton, Hants, England. (author)
  • Dahlen, Sven-ErikKarolinska Institutet (author)
  • Wheelock, Craig E.Karolinska Institutet (author)
  • Karolinska InstitutetKarolinska Inst, Inst Environm Med, Stockholm, Sweden.;Karolinska Inst, Div Physiol Chem 2, Dept Med Biochem & Biophys, Biomed Quarter 9A, S-17177 Stockholm, Sweden.;Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden. (creator_code:org_t)

Related titles

  • In:American Journal of Respiratory and Critical Care MedicineNEW YORK, USA : AMER THORACIC SOC203:1, s. 37-531073-449X1535-4970

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