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  • Öhrman, Caroline (author)

Reorganized Genomic Taxonomy of Francisellaceae Enables Design of Robust Environmental PCR Assays for Detection of Francisella tularensis

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-01-11
  • MDPI,2021
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-180210
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-180210URI
  • https://doi.org/10.3390/microorganisms9010146DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • In recent years, an increasing diversity of species has been recognized within the family Francisellaceae. Unfortunately, novel isolates are sometimes misnamed in initial publications or multiple sources propose different nomenclature for genetically highly similar isolates. Thus, unstructured and occasionally incorrect information can lead to confusion in the scientific community. Historically, detection of Francisella tularensis in environmental samples has been challenging due to the considerable and unknown genetic diversity within the family, which can result in false positive results. We have assembled a comprehensive collection of genome sequences representing most known Francisellaceae species/strains and restructured them according to a taxonomy that is based on phylogenetic structure. From this structured dataset, we identified a small number of genomic regions unique to F. tularensis that are putatively suitable for specific detection of this pathogen in environmental samples. We designed and validated specific PCR assays based on these genetic regions that can be used for the detection of F. tularensis in environmental samples, such as water and air filters.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Sahl, Jason W. (author)
  • Sjödin, Andreas (author)
  • Uneklint, Ingrid (author)
  • Ballard, Rebecca (author)
  • Karlsson, Linda (author)
  • McDonough, Ryelan F. (author)
  • Sundell, David (author)
  • Soria, Kathleen (author)
  • Bäckman, Stina (author)
  • Chase, Kitty (author)
  • Brindefalk, Björn (author)
  • Sozhamannan, Shanmuga (author)
  • Vallesi, Adriana (author)
  • Hägglund, Emil (author)
  • Ramirez-Paredes, Jose Gustavo (author)
  • Thelaus, Johanna (author)
  • Colquhoun, Duncan (author)
  • Myrtennäs, Kerstin (author)
  • Birdsell, Dawn (author)
  • Johansson, Anders,1966-Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Klinisk bakteriologi(Swepub:umu)anjo0135 (author)
  • Wagner, David M. (author)
  • Forsman, Mats (author)
  • Umeå universitetMolekylär Infektionsmedicin, Sverige (MIMS) (creator_code:org_t)

Related titles

  • In:Microorganisms: MDPI9:12076-2607

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