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  • Goedecke, Julia H.South African Med Res Council, Noncommunicable Dis Res Unit, Cape Town, South Africa.;Univ Cape Town, Dept Human Biol, Cape Town, South Africa. (author)

Fatty Acid Metabolism and Associations with Insulin Sensitivity Differs Between Black and White South African Women

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2020-09-30
  • Endocrine Society,2021
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:umu-180212
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-180212URI
  • https://doi.org/10.1210/clinem/dgaa696DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-435722URI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Purpose: Genetic differences in desaturase genes and consequently fatty acid metabolism have been reported. The aims were to examine ethnic differences in serum fatty acid composition and desaturase indices, and assess the ethnic-specific associations with insulin sensitivity (IS) and liver fat in black and white South African (SA) women.Methods: In this cross-sectional study including 92 premenopausal black (n = 46) and white (n = 46) SA women, serum fatty acid composition was measured in cholesteryl ester (CE) and nonesterified fatty acid (NEFA) fractions. Desaturase activities were estimated as product-to-precursor ratios: stearoyl-CoA desaturase-1 (SCD1-16, 16:1n-7/16:0); d-5 desaturase (D5D, 20:4n-6/20:3n-6), and d-6 desaturase (D6D, 18:3n-6/18:2n-6). Whole-body IS was estimated from an oral glucose tolerance test using the Matsuda index. In a subsample (n = 30), liver fat and hepatic IS were measured by 1H-magnetic resonance spectroscopy and hyperinsulinemic euglycemic clamp, respectively.Results: Despite lower whole-body IS (P = .006), black women had higher CE D5D and lower D6D and SCD1-16 indices than white women (P < .01). CE D6D index was associated with lower IS in white women only (r = -0.31, P = .045), whereas D5D index was associated with higher IS in black women only (r = 0.31, P = .041). In the subsample, D6D and SCD1-16 indices were positively and D5D was negatively associated with liver fat (P < .05). Conversely, CE SCD1-16 was negatively associated with hepatic IS (P < .05), but not independently of liver fat. Conclusions: Ethnic differences in fatty acid-derived desaturation indices were observed, with insulin-resistant black SA women paradoxically showing a fatty acid pattern typical for higher insulin sensitivity in European populations.

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  • Chorell, Elin,1981-Umeå universitet,Avdelningen för medicin,Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden.(Swepub:umu)elnpon01 (author)
  • van Jaarsveld, Paul J.South African Med Res Council, Noncommunicable Dis Res Unit, Cape Town, South Africa. (author)
  • Risérus, Ulf,1967-Uppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)ulfriser (author)
  • Olsson, TommyUmeå universitet,Avdelningen för medicin,Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden.(Swepub:umu)tool0003 (author)
  • South African Med Res Council, Noncommunicable Dis Res Unit, Cape Town, South Africa.;Univ Cape Town, Dept Human Biol, Cape Town, South Africa.Avdelningen för medicin (creator_code:org_t)

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  • In:Journal of Clinical Endocrinology and Metabolism: Endocrine Society106:1, s. E140-E1510021-972X1945-7197

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