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Cytogenetic feature...
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Forestier, ErikUmeå universitet,Pediatrik
(author)
Cytogenetic features of acute lymphoblastic and myeloid leukemias in pediatric patients with Down syndrome - an iBFM-SG study.
- Article/chapterEnglish2007
Publisher, publication year, extent ...
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American Society of Hematology,2007
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Numbers
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LIBRIS-ID:oai:DiVA.org:umu-18036
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-18036URI
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https://lup.lub.lu.se/record/1198837URI
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https://doi.org/10.1182/blood-2007-09-114231DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Children with Down syndrome (DS) have a markedly increased risk of acute lymphoblastic and myeloid leukemias (ALL+AML). To identify chromosomal changes cooperating with +21 that may provide information on the pathogenesis of these leukemias, we analyzed 215 DS-ALL and 189 DS-AML. Unlike previous smaller series, a significant proportion of DS-ALL had the typical B-cell precursor ALL abnormalities high hyperdiploidy (HeH; 11%) and t(12;21)(p13;q22) (10%). The HeH DS-ALL were characterized by gains of the same chromosomes as non-DS-HeH, suggesting the same etiology/pathogenesis. In addition, specific genetic subtypes of DS-ALL were suggested by the significant overrepresentation of cases with +X, t(8;14)(q11;q32), and del(9p). Unlike DS-ALL, the common translocations associated with non-DS-AML were rare in DS-AML, which instead were characterized by the frequent presence of dup(1q), del(6q), del(7p), dup(7q), +8, +11, del(16q), and +21. This series of DS leukemias - the largest to date - reveals that DS-ALL is a heterogeneous disorder that comprises both t(12;21) and HeH as well as DS-related abnormalities. Furthermore, this analysis confirms that DS-AML is a distinct entity, originating through other genetic pathways than do non-DS-AML, and suggests that unbalanced changes such as dup(1q), +8, and +21 are involved in the leukemogenic process.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Izraeli, Shai
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Beverloo, Berna
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Haas, Oskar
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Pession, Andrea
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Michalova, Kyra
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Stark, Batia
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Harrison, Christine J
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Teigler-Schlegel, Andrea
(author)
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Johansson, BertilLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Genetiska och epigenetiska studier av barnleukemi,Forskargrupper vid Lunds universitet,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Genetic and epigenetic studies of pediatric leukemia,Lund University Research Groups,Skåne University Hospital(Swepub:lu)kgen-bjo
(author)
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Umeå universitetPediatrik
(creator_code:org_t)
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In:Blood: American Society of Hematology0006-49711528-0020
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