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One-year excess mor...
One-year excess mortality and treatment in surgically treated patients with colorectal cancer : A EURECCA European comparison
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- Bahadoer, Renu R. (author)
- Leiden University Medical Center, Department of Surgery, Albinusdreef 2, Postbus 9600, RC Leiden, Netherlands
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- Bastiaannet, Esther (author)
- Leiden University Medical Center, Department of Surgery, Albinusdreef 2, Postbus 9600, RC Leiden, Netherlands
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- Claassen, Yvette H.M. (author)
- Leiden University Medical Center, Department of Surgery, Albinusdreef 2, Postbus 9600, RC Leiden, Netherlands
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- van der Mark, Marianne (author)
- Netherlands Comprehensive Cancer Organization, Department of Research and Development, Godebaldkwartier 419, Postbus 19079, DB Utrecht, Netherlands
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- van Eycken, Elizabeth (author)
- Belgian Cancer Registry, Koningsstraat 215 Bus 7, Brussels, Belgium
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- Verbeeck, Julie (author)
- Belgian Cancer Registry, Koningsstraat 215 Bus 7, Brussels, Belgium
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- Guren, Marianne G. (author)
- Oslo University Hospital, Department of Oncology and K.G. Jebsen Colorectal Cancer Research Centre, Nydalen, PO, Oslo, Norway
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- Kørner, Hartwig (author)
- Stavanger University Hospital, Stavanger, Department of Gastrointestinal Surgery, Postboks 8100, Stavanger, Norway; University of Bergen, Department of Clinical Medicine, Jonas Lies Veg 87, N-5021, Bergen, Norway
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- Martling, Anna (author)
- Karolinska Institutet
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- Johansson, Robert (author)
- Umeå universitet,Enheten för biobanksforskning
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- van de Velde, Cornelis J.H. (author)
- Leiden University Medical Center, Department of Surgery, Albinusdreef 2, Postbus 9600, RC Leiden, Netherlands
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- Dekker, Jan Willem T. (author)
- Reinier de Graaf Hospital, Department of Surgery, Reinier de Graafweg 5, Postbus 5011, GA Delft, Netherlands
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- English.
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In: European Journal of Surgical Oncology. - : Elsevier. - 0748-7983 .- 1532-2157. ; 47:7, s. 1651-1660
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Abstract
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- Background: Mortality in the first postoperative year represents an accurate reflection of the perioperative risk after colorectal cancer surgery. This research compares one-year mortality after surgery divided into three age-categories (18-64, 65-74, ≥75 years), focusing on time trends and comparing treatment strategies.Material: Population-based data of all patients diagnosed and treated surgically for stage I-III primary colorectal cancer from 2007 to 2016, were collected from Belgium, the Netherlands, Norway, and Sweden. Stratified for age-category and stage, treatment was evaluated, and 30-day, one-year and one-year excess mortality were calculated for colon and rectal cancer separately. Results were evaluated over two-year time periods.Results: Data of 206,024 patients were analysed. Postoperative 30-day and one-year mortality reduced significantly over time in all countries and age-categories. Within the oldest age category, in 2015–2016, one-year excess mortality varied from 9% in Belgium to 4% in Sweden for colon cancer and, from 9% in Belgium to 3% in the other countries for rectal cancer. With increasing age, patients were less likely to receive additional therapy besides surgery. In Belgium, colon cancer patients were more often treated with adjuvant chemotherapy (p < 0.001). For neoadjuvant treatment of rectal cancer, patients in Belgium and Norway were mostly treated with chemoradiotherapy. In the Netherlands and Sweden, radiotherapy alone was preferred (p < 0.001).Conclusions: Despite improvement over time in all countries and age-categories, substantial variation exists in one-year postoperative mortality. Differences in one-year excess postoperative mortality could be due to differences in treatment strategies, highlighting the consequences of under- and over-treatment on cancer survival.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Colorectal neoplasms
- epidemiology
- Internationality
- Mortality
- Treatment
Publication and Content Type
- ref (subject category)
- art (subject category)
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Bahadoer, Renu R ...
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Bastiaannet, Est ...
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Claassen, Yvette ...
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van der Mark, Ma ...
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van Eycken, Eliz ...
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Verbeeck, Julie
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Guren, Marianne ...
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Kørner, Hartwig
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Martling, Anna
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Johansson, Rober ...
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van de Velde, Co ...
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Dekker, Jan Will ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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European Journal ...
- By the university
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Umeå University
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Karolinska Institutet