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Differences between...
Differences between Men and Women in Treatment and Outcome after Traumatic Brain Injury
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- Mikolić, Ana (author)
- Department of Public Health, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands
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- van Klaveren, David (author)
- Department of Public Health, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands; Predictive Analytics and Comparative Effectiveness Center, Institute for Clinical Research and Health Policy Studies/Tufts Medical Center, Boston, Massachusetts, USA
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- Oude Groeniger, Joost (author)
- Department of Public Health, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Public Administration and Sociology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands
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- Wiegers, Eveline J. A. (author)
- Department of Public Health, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands
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- Lingsma, Hester F. (author)
- Department of Public Health, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands
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- Zeldovich, Marina (author)
- Institute of Medical Psychology and Medical Sociology, Georg-August-University, Göttingen, Germany
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- von Steinbüchel, Nicole (author)
- Department of Neurosurgery, Antwerp University Hospital and University of Antwerp, Antwerp, Belgium
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Maas, Andrew I. R. (author)
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- Roeters van Lennep, Jeanine E. (author)
- Department of Internal Medicine, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands
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- Polinder, Suzanne (author)
- Department of Public Health, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands
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- Brorsson, Camilla (contributor)
- Umeå universitet,Institutionen för kirurgisk och perioperativ vetenskap
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- Koskinen, Lars-Owe D., Professor, 1955- (contributor)
- Umeå universitet,Neurovetenskaper
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- Sundström, Nina (contributor)
- Umeå universitet,Institutionen för strålningsvetenskaper
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- Oresic, Matej, 1967- (contributor)
- Örebro universitet,Institutionen för medicinska vetenskaper
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(creator_code:org_t)
- 2020-10-19
- 2021
- English.
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In: Journal of Neurotrauma. - : Mary Ann Liebert. - 0897-7151 .- 1557-9042. ; 38:2, s. 235-251
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Abstract
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- Traumatic brain injury (TBI) is a significant cause of disability, but little is known about sex and gender differences after TBI. We aimed to analyze the association between sex/gender, and the broad range of care pathways, treatment characteristics, and outcomes following mild and moderate/severe TBI. We performed mixed-effects regression analyses in the prospective multi-center Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study, stratified for injury severity and age, and adjusted for baseline characteristics. Outcomes were various care pathway and treatment variables, and 6-month measures of functional outcome, health-related quality of life (HRQoL), post-concussion symptoms (PCS), and mental health symptoms. The study included 2862 adults (36% women) with mild (mTBI; Glasgow Coma Scale [GCS] score 13–15), and 1333 adults (26% women) with moderate/severe TBI (GCS score 3–12). Women were less likely to be admitted to the intensive care unit (ICU; odds ratios [OR] 0.6, 95% confidence interval [CI]: 0.4-0.8) following mTBI. Following moderate/severe TBI, women had a shorter median hospital stay (OR 0.7, 95% CI: 0.5-1.0). Following mTBI, women had poorer outcomes; lower Glasgow Outcome Scale Extended (GOSE; OR 1.4, 95% CI: 1.2-1.6), lower generic and disease-specific HRQoL, and more severe PCS, depression, and anxiety. Among them, women under age 45 and above age 65 years showed worse 6-month outcomes compared with men of the same age. Following moderate/severe TBI, there was no difference in GOSE (OR 0.9, 95% CI: 0.7-1.2), but women reported more severe PCS (OR 1.7, 95% CI: 1.1-2.6). Men and women differ in care pathways and outcomes following TBI. Women generally report worse 6-month outcomes, but the size of differences depend on TBI severity and age. Future studies should examine factors that explain these differences.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- care pathway
- outcomes
- sex differences
- traumatic brain injury
- treatment
Publication and Content Type
- ref (subject category)
- art (subject category)
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Mikolić, Ana
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van Klaveren, Da ...
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Oude Groeniger, ...
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Wiegers, Eveline ...
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Lingsma, Hester ...
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Zeldovich, Marin ...
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von Steinbüchel, ...
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Maas, Andrew I. ...
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Roeters van Lenn ...
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Polinder, Suzann ...
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Brorsson, Camill ...
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Koskinen, Lars-O ...
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Sundström, Nina
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Oresic, Matej, 1 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Journal of Neuro ...
- By the university
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Umeå University
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Örebro University
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Karolinska Institutet