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  • Wilson, Jeffrey M.Division of Allergy & Clinical Immunology, University of Virginia, Va, Charlottesville, United States (author)

α-Gal specific-IgE prevalence and levels in Ecuador and Kenya : Relation to diet, parasites, and IgG4

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • Elsevier,2021
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-181585
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-181585URI
  • https://doi.org/10.1016/j.jaci.2020.12.650DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

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  • Background: IgE to α-Gal is a cause of mammalian meat allergy and has been linked to tick bites in North America, Australia, and Eurasia. Reports from the developing world indicate that α-Gal sensitization is prevalent but has been little investigated. Objective: We sought evidence for the cause(s) of α-Gal sensitization and lack of reported meat allergy among children in less developed settings in Ecuador and Kenya. Methods: IgE to α-Gal and total IgE were assessed in children from Ecuador (n = 599) and Kenya (n = 254) and compared with children with (n = 42) and without known (n = 63) mammalian meat allergy from the southeastern United States. Information on diet, potential risk factors, and helminth infections was available for children from Ecuador. IgG4 to α-Gal and antibodies to regionally representative parasites were assessed in a subset of children. Results: In Ecuador (32%) and Kenya (54%), α-Gal specific IgE was prevalent, but levels were lower than in children with meat allergy from the United States. Sensitization was associated with rural living, antibody markers of Ascaris exposure, and total IgE, but not active infections with Ascaris or Trichuris species. In Ecuador, 87.5% reported consuming beef at least once per week, including 83.9% of those who had α-Gal specific IgE. Levels of α-Gal specific IgG4 were not high in Ecuador, but were greater than in children from the United States. Conclusions: These results suggest that in areas of the developing world with endemic parasitism, α-Gal sensitization is (1) common, (2) associated with Ascaris exposure, and (3) distinguished by a low percentage of specific/total IgE compared with individuals with meat allergy in the United States.

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  • Keshavarz, BehnamDivision of Allergy & Clinical Immunology, University of Virginia, Va, Charlottesville, United States (author)
  • James, Hayley R.Division of Allergy & Clinical Immunology, University of Virginia, Va, Charlottesville, United States (author)
  • Retterer, Maya K.C.Division of Allergy & Clinical Immunology, University of Virginia, Va, Charlottesville, United States (author)
  • Schuyler, Alexander J.Division of Allergy & Clinical Immunology, University of Virginia, Va, Charlottesville, United States (author)
  • Knoedler, AliceDivision of Allergy & Clinical Immunology, University of Virginia, Va, Charlottesville, United States (author)
  • Workman, Lisa J.Division of Allergy & Clinical Immunology, University of Virginia, Va, Charlottesville, United States (author)
  • Ng'ang'a, LucyUnited States International University, Nairobi, Kenya (author)
  • Chico, Martha E.Fundación Ecuatoriana Para Investigación para Salud, Quinindé, Ecuador (author)
  • Rönmark, EvaUmeå universitet,Avdelningen för hållbar hälsa(Swepub:umu)evra0004 (author)
  • Heymann, Peter W.Division of Allergy & Clinical Immunology, University of Virginia, Va, Charlottesville, United States (author)
  • Perzanowski, Matthew S.Mailman School of Public Health, Columbia University, NY, New York, United States (author)
  • Platts-Mills, Thomas A.E.Division of Allergy & Clinical Immunology, University of Virginia, Va, Charlottesville, United States (author)
  • Cooper, Philip J.Fundación Ecuatoriana Para Investigación para Salud, Quinindé, Ecuador; Institute of Infection and Immunity, St George's University of London, London, United Kingdom; Escuela de Medicina, Universidad Internacional del Ecuador, Quito, Ecuador (author)
  • Division of Allergy & Clinical Immunology, University of Virginia, Va, Charlottesville, United StatesUnited States International University, Nairobi, Kenya (creator_code:org_t)

Related titles

  • In:Journal of Allergy and Clinical Immunology: Elsevier147:4, s. 1393-1401.e70091-67491097-6825

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