onr:"swepub:oai:DiVA.org:umu-182097"
Search: onr:"swepub:oai:DiVA.org:umu-182097" > Synthesis and immun...
- 1 of 1
- Previous record
- Next record
- To hitlist
Synthesis and immunological evaluation of the unnatural β-linked mucin-1 Thomsen-Friedenreich conjugate
-
- Wu, Xuanjun (author)
- National Glycoengineering Research Center, Shandong University, Shandong, Qingdao, China; Department of Chemistry, Michigan State University, MI, East Lansing, United States
-
- McFall-Boegeman, Hunter (author)
- Department of Chemistry, Michigan State University, MI, East Lansing, United States; Institute for Quantitative Health Science and Engineering, Michigan State University, MI, East Lansing, United States
-
- Rashidijahanabad, Zahra (author)
- Department of Chemistry, Michigan State University, MI, East Lansing, United States; Institute for Quantitative Health Science and Engineering, Michigan State University, MI, East Lansing, United States
- show more...
- show less...
- (creator_code:org_t)
- 2021
- 2021
- English.
- In: Organic and biomolecular chemistry. - : Royal Society of Chemistry. - 1477-0520 .- 1477-0539. ; 19:11, s. 2448-2455
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- MUC1 glycopeptides are attractive antigens for anti-cancer vaccine development. One potential drawback in using the native MUC1 glycopeptide for vaccine design is the instability of theO-glycosyl linkage between the glycan and the peptide backbone to glycosidase. To overcome this challenge, a MUC1 glycopeptide mimic has been synthesized with the galactose-galactosamine disaccharide linked with threonine (Thomsen-Friedenreich or Tf antigen) through an unnatural β-glycosyl bond. The resulting MUC1-β-Tf had a much-enhanced stability toward a glycosidase capable of cleaving the glycan from the corresponding MUC1 glycopeptide with the natural α-Tf linkage. The MUC1-β-Tf was subsequently conjugated with a powerful carrier bacteriophage Qβ. The conjugate induced high levels of IgG antibodies in clinically relevant human MUC1 transgenic mice, which cross-recognized not only the natural MUC1-α-Tf glycopeptide but also MUC1 expressing tumor cells, supporting the notion that a simple switch of the stereochemistry of the glycan/peptide linkage can be a strategy for anti-cancer vaccine epitope design for glycopeptides.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Organic and biomolecular chemistry (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Wu, Xuanjun
- McFall-Boegeman, ...
- Rashidijahanabad ...
- Liu, Kunli
- Pett, Christian
- Yu, Jin
- show more...
- Schorlemer, Manu ...
- Ramadan, Sherif
- Behren, Sandra
- Westerlind, Ulri ...
- Huang, Xuefei
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Medical Biotechn ...
- and Medical Biotechn ...
- Articles in the publication
- Organic and biom ...
- By the university
- Umeå University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
