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Herpesvirus infecti...
Herpesvirus infections, antiviral treatment, and the risk ofdementia : a registry-based cohort study in Sweden
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- Lopatko Lindman, Karin (author)
- Umeå universitet,Geriatrik,Department of Community Medicine and Rehabilitation, Geriatric Medicine Umeå University Umeå Sweden
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- Hemmingsson, Eva-Stina (author)
- Umeå universitet,Geriatrik,Department of Community Medicine and Rehabilitation, Geriatric Medicine Umeå University Umeå Sweden
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- Weidung, Bodil (author)
- Uppsala universitet,Umeå universitet,Geriatrik,Department of Public Health and Caring Sciences, Geriatric Medicine, Uppsala University, Uppsala, Sweden,Department of Community Medicine and Rehabilitation, Geriatric Medicine Umeå University Umeå Sweden
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- Brännström, Jon (author)
- Umeå universitet,Geriatrik,Department of Community Medicine and Rehabilitation, Geriatric Medicine Umeå University Umeå Sweden
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- Josefsson, Maria, 1979- (author)
- Umeå universitet,Enheten för demografi och åldrandeforskning (CEDAR),Statistik,Centre for Demographic and Ageing Research Umeå University Umeå Sweden
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- Olsson, Jan (author)
- Umeå universitet,Avdelningen för virologi,Department of Clinical Microbiology, Virology Umeå University Umeå Sweden
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- Elgh, Fredrik, 1957- (author)
- Umeå universitet,Avdelningen för virologi,Department of Clinical Microbiology, Virology Umeå University Umeå Sweden
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- Nordström, Peter (author)
- Umeå universitet,Geriatrik,Department of Community Medicine and Rehabilitation, Geriatric Medicine Umeå University Umeå Sweden
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- Lövheim, Hugo, 1981- (author)
- Umeå universitet,Geriatrik,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Department of Community Medicine and Rehabilitation, Geriatric Medicine Umeå University Umeå Sweden;Wallenberg Centre for Molecular Medicine (WCMM) Umeå University Umeå Sweden
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(creator_code:org_t)
- 2021-02-14
- 2021
- English.
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In: Alzheimer’s & Dementia. - : John Wiley & Sons. - 2352-8737. ; 7:1
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Abstract
Subject headings
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- Introduction: Herpesviruses, including Herpes simplex virus type 1 (HSV1) and varicella zoster‐virus (VZV), have been implicated in Alzheimer's disease (AD) development. Likewise, antiviral treatment has been suggested to protect against dementia development in herpes‐infected individuals.Methods: The study enrolled 265,172 subjects aged ≥ 50 years, with diagnoses of VZV or HSV, or prescribed antiviral drugs between 31 December 2005 and 31 December 2017. Controls were matched in a 1:1 ratio by sex and birth year.Results: Antiviral treatment was associated with decreased risk of dementia (adjusted hazard ratio [HR] 0.89, 95% confidence interval [CI] 0.86 to 0.92), while herpes infection without antiviral drugs increased the risk of dementia (adjusted HR 1.50, 95% CI 1.29 to 1.74).Discussion: Antiviral treatment was associated with a reduced long‐term risk of dementia among individuals with overt signs of herpes infection. This is consistent with earlier findings indicating that herpesviruses are involved in the pathogenesis of AD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer’s disease
- antiviral agents
- dementia
- herpes simplex
- herpes zoster
- retrospective cohort study
- varicella zoster
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Lopatko Lindman, ...
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Hemmingsson, Eva ...
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Weidung, Bodil
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Brännström, Jon
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Josefsson, Maria ...
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Olsson, Jan
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Elgh, Fredrik, 1 ...
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Nordström, Peter
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Lövheim, Hugo, 1 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Other Medical an ...
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and Gerontology spec ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimer’s & De ...
- By the university
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Umeå University
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Uppsala University