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Mapping atopic derm...
Mapping atopic dermatitis and anti–IL-22 response signatures to type 2–low severe neutrophilic asthma
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- Badi, Yusef Eamon (author)
- National Heart and Lung Institute, the Imperial College London, London, United Kingdom; NIHR Imperial Biomedical Research Centre, London, United Kingdom; Data Science Institute, Imperial College London, London, United Kingdom,Imperial Coll London, Natl Heart & Lung Inst, Dovehouse St, London SW3 6LY, England.;NIHR Imperial Biomed Res Ctr, London, England.;Imperial Coll London, Data Sci Inst, London, England.
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- Pavel, Ana B. (author)
- Laboratory of Inflammatory Skin Diseases, Department of Dermatology, Icahn School of Medicine at Mount Sinai, NY, New York, United States; Department of Biomedical Engineering, The University of Mississippi, Miss, Oxford, United States,Icahn Sch Med Mt Sinai, Dept Dermatol, Lab Inflammatory Skin Dis, New York, NY 10029 USA.;Univ Mississippi, Dept Biomed Engn, Oxford, MS USA.
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- Pavlidis, Stelios (author)
- Data Science Institute, Imperial College London, London, United Kingdom,Imperial Coll London, Data Sci Inst, London, England.;Janssen Res & Dev Ltd, High Wycombe, Bucks, England.
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- Riley, John H. (author)
- GSK Respiratory Therapeutic Area Unit, Stevenage, United Kingdom,GSK Resp Therapeut Area Unit, Stevenage, Herts, England.
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- Bates, Stewart (author)
- GSK Respiratory Therapeutic Area Unit, Stevenage, United Kingdom,GSK Resp Therapeut Area Unit, Stevenage, Herts, England.
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- Kermani, Nazanin Zounemat (author)
- Data Science Institute, Imperial College London, London, United Kingdom,Imperial Coll London, Data Sci Inst, London, England.
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- Knowles, Richard (author)
- Knowles Consulting, Stevenage, United Kingdom,Knowles Consulting, Stevenage, Herts, England.
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- Kolmert, Johan (author)
- Karolinska Institutet,Karolinska Inst, Inst Environm Med, Ctr Allergy Res, Stockholm, Sweden.;Karolinska Inst, Dept Med Biochem & Biophys, Div Physiol Chem 2, Stockholm, Sweden.
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- Wheelock, Craig E. (author)
- Karolinska Institutet,Karolinska Inst, Dept Med Biochem & Biophys, Div Physiol Chem 2, Stockholm, Sweden.
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- Worsley, Sally (author)
- GSK Value Evidence and Outcomes, Brentford, United Kingdom,GSK Value Evidence & Outcomes, Brentford, England.
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- Uddin, Mohib (author)
- Respiratory Global Medicines Development, AstraZeneca, Gothenburg, Sweden,AstraZeneca, Resp Global Med Dev, Gothenburg, Sweden.
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- Alving, Kjell, 1959- (author)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Uppsala Univ, Dept Womens & Childrens Hlth Paediat Res, Uppsala, Sweden.
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- Bakke, Per S. (author)
- Department of Clinical Science, University of Bergen, Bergen, Norway,Univ Bergen, Dept Clin Sci, Bergen, Norway.
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- Behndig, Annelie F., 1963- (author)
- Umeå universitet,Lungmedicin,Umeå Univ, Dept Publ Hlth & Clin Med, Div Med Resp Med, Umeå, Sweden.
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- Caruso, Massimo (author)
- Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy,Univ Catania, Dept Biomed & Biotechnol Sci, Catania, Italy.
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- Chanez, Pascal (author)
- Aix-Marseille Universite, Assistance Publique des Hopitaux de Marseille, Clinic des Bronches, Allergies et Sommeil, Marseille, France,Aix Marseille Univ, AP HM, Clin Bronches Allergies & Sommeil, Marseille, France.
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- Fleming, Louise J. (author)
- National Heart and Lung Institute, the Imperial College London, London, United Kingdom; NIHR Imperial Biomedical Research Centre, London, United Kingdom,Imperial Coll London, Natl Heart & Lung Inst, Dovehouse St, London SW3 6LY, England.;NIHR Imperial Biomed Res Ctr, London, England.
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- Fowler, Stephen J. (author)
- Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom; Manchester Academic Health Science Centre and NIHR Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom,Univ Manchester, Fac Biol Med & Hlth, Sch Biol Sci, Div Infect Immun & Resp Med, Manchester, Lancs, England.;Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England.;Manchester Univ Hosp NHS Fdn Trust, NIHR Biomed Res Ctr, Manchester, Lancs, England.
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- Frey, Urs (author)
- University Children's Hospital Basel, University of Basel, Basel, Switzerland,Univ Basel, Univ Childrens Hosp Basel, Basel, Switzerland.
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- Howarth, Peter (author)
- Clinical and Experimental Sciences and Human Development in Health, University of Southampton Faculty of Medicine, Southampton, United Kingdom; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom; David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Isle of Wight, Newport, United Kingdom,Univ Southampton, Clin & Expt Sci & Human Dev Hlth, Fac Med, Southampton, Hants, England.;Univ Hosp Southampton NHS Fdn Trust, NIHR Southampton Biomed Res Ctr, Southampton, Hants, England.;St Marys Hosp, David Hide Asthma & Allergy Res Ctr, Newport, Wight, England.
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- Horváth, Ildikó (author)
- Department of Public Health, Semmelweis University, Budapest, Hungary,Semmelweis Univ, Dept Publ Hlth, Budapest, Hungary.
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- Krug, Norbert (author)
- Fraunhofer ITEM, Hannover, Germany.
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- Maitland-van der Zee, Anke H. (author)
- Department of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, The Netherlands, Amsterdam, Netherlands,Univ Amsterdam, Dept Resp Med, Amsterdam UMC, Amsterdam, Netherlands.
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- Montuschi, Paolo (author)
- Pharmacology, Catholic University of the Sacred Heart, Agostino Gemelli University Hospital Foundation, Rome, Italy,Univ Cattolica Sacro Cuore, Agostino Gemelli Univ Hosp Fdn, Pharmacol, Rome, Italy.
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- Roberts, Graham (author)
- Clinical and Experimental Sciences and Human Development in Health, University of Southampton Faculty of Medicine, Southampton, United Kingdom; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom; David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Isle of Wight, Newport, United Kingdom,Univ Southampton, Clin & Expt Sci & Human Dev Hlth, Fac Med, Southampton, Hants, England.;Univ Hosp Southampton NHS Fdn Trust, NIHR Southampton Biomed Res Ctr, Southampton, Hants, England.;St Marys Hosp, David Hide Asthma & Allergy Res Ctr, Newport, Wight, England.
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- Sanak, Marek (author)
- Department of Internal Medicine, Jagiellonian University Medical College, Krakow, Poland,Jagiellonian Univ Med Coll, Dept Internal Med, Krakow, Poland.
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- Shaw, Dominick E. (author)
- University of Nottingham, NIHR Biomedical Research Centre, Nottingham, United Kingdom,Univ Nottingham, NIHR Biomed Res Ctr, Nottingham, England.
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- Singer, Florian (author)
- Division of Respiratory Medicine, Department of Paediatrics, Inselspital, University of Bern, Bern, Switzerland,Univ Bern, Dept Paediat, Div Resp Med, Inselspital, Bern, Switzerland.
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- Sterk, Peter J. (author)
- Department of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, The Netherlands, Amsterdam, Netherlands,Univ Amsterdam, Dept Resp Med, Amsterdam UMC, Amsterdam, Netherlands.
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- Djukanovic, Ratko (author)
- Clinical and Experimental Sciences and Human Development in Health, University of Southampton Faculty of Medicine, Southampton, United Kingdom; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom; David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Isle of Wight, Newport, United Kingdom,Univ Southampton, Clin & Expt Sci & Human Dev Hlth, Fac Med, Southampton, Hants, England.;Univ Hosp Southampton NHS Fdn Trust, NIHR Southampton Biomed Res Ctr, Southampton, Hants, England.;St Marys Hosp, David Hide Asthma & Allergy Res Ctr, Newport, Wight, England.
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- Dahlen, Sven-Eric (author)
- Karolinska Institutet,Karolinska Inst, Inst Environm Med, Ctr Allergy Res, Stockholm, Sweden.
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- Guo, Yi-Ke (author)
- Data Science Institute, Imperial College London, London, United Kingdom,Imperial Coll London, Data Sci Inst, London, England.
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- Chung, Kian Fan (author)
- National Heart and Lung Institute, the Imperial College London, London, United Kingdom; NIHR Imperial Biomedical Research Centre, London, United Kingdom,Imperial Coll London, Natl Heart & Lung Inst, Dovehouse St, London SW3 6LY, England.;NIHR Imperial Biomed Res Ctr, London, England.
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- Guttman-Yassky, Emma (author)
- Laboratory of Inflammatory Skin Diseases, Department of Dermatology, Icahn School of Medicine at Mount Sinai, NY, New York, United States,Icahn Sch Med Mt Sinai, Dept Dermatol, Lab Inflammatory Skin Dis, New York, NY 10029 USA.
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- Adcock, Ian M. (author)
- National Heart and Lung Institute, the Imperial College London, London, United Kingdom; NIHR Imperial Biomedical Research Centre, London, United Kingdom,Imperial Coll London, Natl Heart & Lung Inst, Dovehouse St, London SW3 6LY, England.;NIHR Imperial Biomed Res Ctr, London, England.
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Chung, AF (author)
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National Heart and Lung Institute, the Imperial College London, London, United Kingdom; NIHR Imperial Biomedical Research Centre, London, United Kingdom; Data Science Institute, Imperial College London, London, United Kingdom Imperial Coll London, Natl Heart & Lung Inst, Dovehouse St, London SW3 6LY, England;NIHR Imperial Biomed Res Ctr, London, England.;Imperial Coll London, Data Sci Inst, London, England. (creator_code:org_t)
- Elsevier, 2022
- 2022
- English.
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In: Journal of Allergy and Clinical Immunology. - : Elsevier. - 0091-6749 .- 1097-6825. ; 149:1, s. 89-101
- Related links:
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Abstract
Subject headings
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- Background: Transcriptomic changes in patients who respond clinically to biological therapies may identify responses in other tissues or diseases.Objective: We sought to determine whether a disease signature identified in atopic dermatitis (AD) is seen in adults with severe asthma and whether a transcriptomic signature for patients with AD who respond clinically to anti–IL-22 (fezakinumab [FZ]) is enriched in severe asthma.Methods: An AD disease signature was obtained from analysis of differentially expressed genes between AD lesional and nonlesional skin biopsies. Differentially expressed genes from lesional skin from therapeutic superresponders before and after 12 weeks of FZ treatment defined the FZ-response signature. Gene set variation analysis was used to produce enrichment scores of AD and FZ-response signatures in the Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes asthma cohort.Results: The AD disease signature (112 upregulated genes) encompassing inflammatory, T-cell, TH2, and TH17/TH22 pathways was enriched in the blood and sputum of patients with asthma with increasing severity. Patients with asthma with sputum neutrophilia and mixed granulocyte phenotypes were the most enriched (P <.05). The FZ-response signature (296 downregulated genes) was enriched in asthmatic blood (P <.05) and particularly in neutrophilic and mixed granulocytic sputum (P <.05). These data were confirmed in sputum of the Airway Disease Endotyping for Personalized Therapeutics cohort. IL-22 mRNA across tissues did not correlate with FZ-response enrichment scores, but this response signature correlated with TH22/IL-22 pathways.Conclusions: The FZ-response signature in AD identifies severe neutrophilic asthmatic patients as potential responders to FZ therapy. This approach will help identify patients for future asthma clinical trials of drugs used successfully in other chronic diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- atopic dermatitis
- Fezakinumab
- gene set variation analysis
- IL-22
- severe asthma
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Badi, Yusef Eamo ...
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Pavel, Ana B.
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Pavlidis, Stelio ...
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Riley, John H.
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Bates, Stewart
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Kermani, Nazanin ...
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show more...
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Knowles, Richard
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Kolmert, Johan
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Wheelock, Craig ...
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Worsley, Sally
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Uddin, Mohib
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Alving, Kjell, 1 ...
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Bakke, Per S.
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Behndig, Annelie ...
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Caruso, Massimo
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Chanez, Pascal
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Fleming, Louise ...
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Fowler, Stephen ...
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Frey, Urs
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Howarth, Peter
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Horváth, Ildikó
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Krug, Norbert
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Maitland-van der ...
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Montuschi, Paolo
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Roberts, Graham
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Sanak, Marek
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Shaw, Dominick E ...
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Singer, Florian
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Sterk, Peter J.
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Djukanovic, Ratk ...
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Dahlen, Sven-Eri ...
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Guo, Yi-Ke
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Chung, Kian Fan
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Guttman-Yassky, ...
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Adcock, Ian M.
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Chung, AF
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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Journal of Aller ...
- By the university
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Umeå University
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Karolinska Institutet
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Uppsala University