Search: onr:"swepub:oai:DiVA.org:umu-186279" >
Variants in BANK1 a...
Variants in BANK1 are associated with lupus nephritis of European ancestry
-
- Bolin, Karin (author)
- Uppsala universitet,Uppsala University,Science for Life Laboratory, SciLifeLab,Institutionen för medicinska vetenskaper
-
- Imgenberg-Kreuz, Juliana (author)
- Uppsala universitet,Uppsala University,Science for Life Laboratory, SciLifeLab,Institutionen för medicinska vetenskaper
-
- Leonard, Dag, 1975- (author)
- Uppsala universitet,Uppsala University,Institutionen för medicinska vetenskaper,Science for Life Laboratory, SciLifeLab
-
show more...
-
- Sandling, Johanna K. (author)
- Uppsala universitet,Uppsala University,Science for Life Laboratory, SciLifeLab,Institutionen för medicinska vetenskaper
-
- Bengtsson, Anders A. (author)
- Uppsala universitet,Lund University,Lunds universitet,Uppsala University,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Institutionen för medicinska vetenskaper,Science for Life Laboratory, SciLifeLab
-
- Pucholt, Pascal (author)
- Uppsala universitet,Uppsala University,Science for Life Laboratory, SciLifeLab,Institutionen för medicinska vetenskaper
-
- Haarhaus, Malena Loberg (author)
- Karolinska Institute,Karolinska University Hospital
-
- Almlöf, Jonas Carlsson (author)
- Uppsala universitet,Uppsala University,Institutionen för medicinska vetenskaper
-
- Nititham, Joanne (author)
- Russell/Engleman Rheumatology Research Center, Department of Medicine, University of California San Francisco, CA, San Francisco, United States,Univ Calif San Francisco, CA 94132 USA
-
- Jönsen, Andreas (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Sjöwall, Christopher (author)
- Linköping University,Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland
-
- Bengtsson, Anders A. (author)
- Department of Rheumatology, Lund University, Lund, Sweden
-
- Rantapää-Dahlqvist, Solbritt (author)
- Umeå University,Umeå universitet,Avdelningen för medicin,Umea Univ, Sweden
-
- Svenungsson, Elisabet (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
-
- Gunnarsson, Iva (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
-
- Syvänen, Ann-Christine, 1950- (author)
- Uppsala universitet,Uppsala University,Molekylär medicin,Science for Life Laboratory, SciLifeLab
-
- Lerang, Karoline (author)
- Department of Rheumatology, University of Oslo, Oslo, Norway,Univ Oslo, Norway
-
- Troldborg, Anne (author)
- Department of Rheumatology, Aarhus University Hospital and Department of Biomedicine, Aarhus University, Aarhus, Denmark,Aarhus Univ Hosp, Denmark; Aarhus Univ, Denmark
-
- Voss, Anne (author)
- Department of Rheumatology, Odense University Hospital, Odense, Denmark,Odense Univ Hosp, Denmark
-
- Molberg, Øyvind (author)
- Department of Rheumatology, University of Oslo, Oslo, Norway,Univ Oslo, Norway
-
- Jacobsen, Søren (author)
- Department of Clinical Medicine, Copenhagen University Hospital, Copenhagen, Denmark,Copenhagen Univ Hosp, Denmark
-
- Criswell, Lindsey (author)
- Russell/Engleman Rheumatology Research Center, Department of Medicine, University of California San Francisco, CA, San Francisco, United States,Univ Calif San Francisco, CA 94132 USA
-
- Rönnblom, Lars (author)
- Uppsala universitet,Uppsala University,Institutionen för medicinska vetenskaper,Science for Life Laboratory, SciLifeLab
-
- Nordmark, Gunnel (author)
- Uppsala universitet,Uppsala University,Institutionen för medicinska vetenskaper,Science for Life Laboratory, SciLifeLab
-
Molberg, O (author)
-
show less...
-
(creator_code:org_t)
- 2021-06-14
- 2021
- English.
-
In: Genes and Immunity. - : Springer Nature. - 1466-4879 .- 1476-5470. ; 22:3, s. 194-202
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://umu.diva-por... (primary) (Raw object)
-
https://www.nature.c...
-
https://liu.diva-por... (primary) (Raw object)
-
http://dx.doi.org/10... (free)
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://lup.lub.lu.s...
-
https://urn.kb.se/re...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- The genetic background of lupus nephritis (LN) has not been completely elucidated. We performed a case-only study of 2886 SLE patients, including 947 (33%) with LN. Renal biopsies were available from 396 patients. The discovery cohort (Sweden, n = 1091) and replication cohort 1 (US, n = 962) were genotyped on the Immunochip and replication cohort 2 (Denmark/Norway, n = 833) on a custom array. Patients with LN, proliferative nephritis, or LN with end-stage renal disease were compared with SLE without nephritis. Six loci were associated with LN (p < 1 × 10−4, NFKBIA, CACNA1S, ITGA1, BANK1, OR2Y, and ACER3) in the discovery cohort. Variants in BANK1 showed the strongest association with LN in replication cohort 1 (p = 9.5 × 10−4) and proliferative nephritis in a meta-analysis of discovery and replication cohort 1. There was a weak association between BANK1 and LN in replication cohort 2 (p = 0.052), and in the meta-analysis of all three cohorts the association was strengthened (p = 2.2 × 10−7). DNA methylation data in 180 LN patients demonstrated methylation quantitative trait loci (meQTL) effects between a CpG site and BANK1 variants. To conclude, we describe genetic variations in BANK1 associated with LN and evidence for genetic regulation of DNA methylation within the BANK1 locus. This indicates a role for BANK1 in LN pathogenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Bolin, Karin
-
Imgenberg-Kreuz, ...
-
Leonard, Dag, 19 ...
-
Sandling, Johann ...
-
Bengtsson, Ander ...
-
Pucholt, Pascal
-
show more...
-
Haarhaus, Malena ...
-
Almlöf, Jonas Ca ...
-
Nititham, Joanne
-
Jönsen, Andreas
-
Sjöwall, Christo ...
-
Rantapää-Dahlqvi ...
-
Svenungsson, Eli ...
-
Gunnarsson, Iva
-
Syvänen, Ann-Chr ...
-
Lerang, Karoline
-
Troldborg, Anne
-
Voss, Anne
-
Molberg, Øyvind
-
Jacobsen, Søren
-
Criswell, Lindse ...
-
Rönnblom, Lars
-
Nordmark, Gunnel
-
Molberg, O
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Rheumatology and ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Medical Genetics
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
- Articles in the publication
-
Genes and Immuni ...
- By the university
-
Umeå University
-
Linköping University
-
Lund University
-
Uppsala University
-
Karolinska Institutet