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Generation of plasm...
Generation of plasma cells and CD27-IgD- B cells during hantavirus infection is associated with distinct pathological findings
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- Kerkman, Priscilla (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Umeå Centre for Microbial Research (UCMR)
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- Dernstedt, Andy (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Umeå Centre for Microbial Research (UCMR)
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- Tadala, Lalitha (author)
- Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten),Umeå Centre for Microbial Research (UCMR),Andrea Puhar
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Mittler, Eva (author)
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- Dannborg, Mirjam (author)
- Umeå universitet,Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten),Molekylär Infektionsmedicin, Sverige (MIMS),Andrea Puhar
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- Sundling, Christopher (author)
- Karolinska Institutet
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- Maleki, Kimia T. (author)
- Karolinska Institutet
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Tauriainen, Johanna (author)
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- Tuiskunen-Bäck, Anne (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Umeå Centre for Microbial Research (UCMR)
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- Wigren Byström, Julia (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Umeå Centre for Microbial Research (UCMR)
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- Ocaya, Pauline (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Umeå Centre for Microbial Research (UCMR)
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- Thunberg, Therese, 1977- (author)
- Umeå universitet,Umeå Centre for Microbial Research (UCMR),Institutionen för klinisk mikrobiologi
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- Jangra, Rohit K (author)
- Karolinska Institutet
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Román-Sosa, Gleyder (author)
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Guardado-Calvo, Pablo (author)
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Rey, Feilx A. (author)
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Klingström, Jonas (author)
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Chandran, Kartik (author)
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- Puhar, Andrea, 1978- (author)
- Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten),Andrea Puhar
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- Ahlm, Clas, 1956- (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Umeå Centre for Microbial Research (UCMR)
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- Forsell, Mattias N. E. (author)
- Umeå universitet,Umeå Centre for Microbial Research (UCMR),Institutionen för klinisk mikrobiologi
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(creator_code:org_t)
- 2021-07-12
- 2021
- English.
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In: Clinical & Translational Immunology (CTI). - : John Wiley & Sons. - 2050-0068. ; 10
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Abstract
Subject headings
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- Objective: Human hantavirus infections can cause haemorrhagic fever with renal syndrome (HFRS). The pathogenic mechanisms arenot fully understood, nor if they affect the humoral immune system. The objective of this study was to investigate humoral immune responses to hantavirus infection and to correlate them to the typical features of HFRS: thrombocytopenia and transient kidney dysfunction.Methods: We performed a comprehensive characterisation of longitudinal antiviral B-cell responses of 26 hantavirus patients and combined this with paired clinical data. In addition, we measured extracellular adenosine triphosphate (ATP)and its breakdown products in circulation and performed in vitro stimulations to address its effect on B cells.Results: We found that thrombocytopenia was correlated to an elevated frequency of plasmablasts in circulation. In contrast, kidney dysfunction was indicative of an accumulation of CD27-IgD- B cells and CD27/low plasmablasts. Finally, we provide evidence that high levels of extracellular ATP and matrix metalloproteinase 8 can contribute to shedding of CD27 during human hantavirus infection.Conclusion: Our findings demonstrate that thrombocytopenia and kidneydysfunction associate with distinctly different effects on the humoral immune system. Moreover, hantavirus-infectedindividuals have significantly elevated levels of extracellular ATP incirculation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- antibodies
- atypical B cells
- B cells
- haemorrhagic fever with renal syndrome
- hantavirus
- plasmablasts
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kerkman, Priscil ...
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Dernstedt, Andy
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Tadala, Lalitha
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Mittler, Eva
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Dannborg, Mirjam
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Sundling, Christ ...
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show more...
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Maleki, Kimia T.
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Tauriainen, Joha ...
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Tuiskunen-Bäck, ...
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Wigren Byström, ...
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Ocaya, Pauline
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Thunberg, Theres ...
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Jangra, Rohit K
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Román-Sosa, Gley ...
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Guardado-Calvo, ...
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Rey, Feilx A.
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Klingström, Jona ...
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Chandran, Kartik
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Puhar, Andrea, 1 ...
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Ahlm, Clas, 1956 ...
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Forsell, Mattias ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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Clinical & Trans ...
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Umeå University
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Karolinska Institutet