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Elevated Faecal Calprotectin in Patients with a Normal Colonoscopy : Does It Matter in Clinical Practice? A Retrospective Observational Study
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- Hovstadius, Henrik (author)
- Umeå universitet,Avdelningen för medicin
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- Lundgren, David (author)
- Umeå universitet,Avdelningen för medicin
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- Karling, Pontus (author)
- Umeå universitet,Avdelningen för medicin
- (creator_code:org_t)
- 2021-02-17
- 2021
- English.
- In: Inflammatory Intestinal Diseases. - : S. Karger. - 2296-9403 .- 2296-9365. ; 6, s. 101-108
- Journal article (peer-reviewed)
Abstract
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- Introduction: Faecal calprotectin (FC) is commonly used as a diagnostic tool for patients with gastrointestinal (GI) symptoms. However, there is uncertainty in daily clinical practice how to interpret an elevated FC in patients with a normal colonoscopy. We investigated if patients with a normal colonoscopy but with an elevated FC more often were diagnosed with a GI disease in a 3-year follow-up period.Methods: Patients referred for colonoscopy (n = 1,263) to the Umeå University Hospital endoscopy unit between 2007 and 2013 performed a FC test (CALPRO®) on the day before bowel preparation. A medical chart review was performed on all patients who had normal findings on their colonoscopy (n = 585, median age 64 years).Results: Thirty-four percent of the patients (n = 202) with normal colonoscopy had elevated FC (>50 μg/g), and these patients were more frequently diagnosed with upper GI disease during the follow-up period than patients with normal FC levels (9.9 vs. 4.7%; p = 0.015). The upper GI diseases were mainly benign (i.e., gastritis). In a binary logistic regression analysis controlling for age, gender, nonsteroid anti-inflammatory drug use, and proton-pump inhibitor use, there was no difference for a new diagnosis of upper GI disease in the follow-up period (multivariate OR 1.70; 95% CI: 0.77–3.74). There was no difference in a new diagnosis of lower GI disease (6.4 vs. 5.2%; p = 0.545) or cardiovascular disease/death (multivariate OR 1.68; 95% CI: 0.83–3.42) in the follow-up period between patients with elevated versus normal FC levels.Conclusions: In patients with a normal colonoscopy, a simultaneously measured increased FC level was not associated with an increased risk for significant GI disease during a follow-up period of 3 years.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- Faecal calprotectin
- Colonoscopy
- Cardiovascular disease
- Colorectal cancer
- Diverticular disease
- Esophagitis
- Gastritis
- Inflammatory bowel disease
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- ref (subject category)
- art (subject category)
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