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Elevated Faecal Cal...
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Hovstadius, HenrikUmeå universitet,Avdelningen för medicin
(author)
Elevated Faecal Calprotectin in Patients with a Normal Colonoscopy : Does It Matter in Clinical Practice? A Retrospective Observational Study
- Article/chapterEnglish2021
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2021-02-17
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S. Karger,2021
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LIBRIS-ID:oai:DiVA.org:umu-186650
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-186650URI
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https://doi.org/10.1159/000513473DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Introduction: Faecal calprotectin (FC) is commonly used as a diagnostic tool for patients with gastrointestinal (GI) symptoms. However, there is uncertainty in daily clinical practice how to interpret an elevated FC in patients with a normal colonoscopy. We investigated if patients with a normal colonoscopy but with an elevated FC more often were diagnosed with a GI disease in a 3-year follow-up period.Methods: Patients referred for colonoscopy (n = 1,263) to the Umeå University Hospital endoscopy unit between 2007 and 2013 performed a FC test (CALPRO®) on the day before bowel preparation. A medical chart review was performed on all patients who had normal findings on their colonoscopy (n = 585, median age 64 years).Results: Thirty-four percent of the patients (n = 202) with normal colonoscopy had elevated FC (>50 μg/g), and these patients were more frequently diagnosed with upper GI disease during the follow-up period than patients with normal FC levels (9.9 vs. 4.7%; p = 0.015). The upper GI diseases were mainly benign (i.e., gastritis). In a binary logistic regression analysis controlling for age, gender, nonsteroid anti-inflammatory drug use, and proton-pump inhibitor use, there was no difference for a new diagnosis of upper GI disease in the follow-up period (multivariate OR 1.70; 95% CI: 0.77–3.74). There was no difference in a new diagnosis of lower GI disease (6.4 vs. 5.2%; p = 0.545) or cardiovascular disease/death (multivariate OR 1.68; 95% CI: 0.83–3.42) in the follow-up period between patients with elevated versus normal FC levels.Conclusions: In patients with a normal colonoscopy, a simultaneously measured increased FC level was not associated with an increased risk for significant GI disease during a follow-up period of 3 years.
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Lundgren, DavidUmeå universitet,Avdelningen för medicin(Swepub:umu)dadlun96
(author)
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Karling, PontusUmeå universitet,Avdelningen för medicin(Swepub:umu)peakag84
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Umeå universitetAvdelningen för medicin
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Related titles
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In:Inflammatory Intestinal Diseases: S. Karger6, s. 101-1082296-94032296-9365
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