onr:"swepub:oai:DiVA.org:umu-187009"
Search: onr:"swepub:oai:DiVA.org:umu-187009" > CD99 and polymeric ...
- 1 of 1
- Previous record
- Next record
- To hitlist
CD99 and polymeric immunoglobulin receptor peptides deregulation in critical COVID-19 : A potential link to molecular pathophysiology?
- Siwy, Justyna (author)
- Wendt, Ralph (author)
- Albalat, Amaya (author)
- show more...
- He, Tianlin (author)
- Mischak, Harald (author)
- Mullen, William (author)
- Latosinska, Agnieszka (author)
- Lübbert, Christoph (author)
- Kalbitz, Sven (author)
- Mebazaa, Alexandre (author)
- Spasovski, Goce (author)
- Wiech, Thorsten (author)
- Staessen, Jan A. (author)
- Wolf, Johannes (author)
- Beige, Joachim (author)
- show less...
- (creator_code:org_t)
- 2021-08-21
- 2021
- English.
- In: Proteomics. - : John Wiley & Sons. - 1615-9853 .- 1615-9861. ; 21:20
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Identification of significant changes in urinary peptides may enable improved understanding of molecular disease mechanisms. We aimed towards identifying urinary peptides associated with critical course of COVID-19 to yield hypotheses on molecular pathophysiological mechanisms in disease development. In this multicentre prospective study urine samples of PCR-confirmed COVID-19 patients were collected in different centres across Europe. The urinary peptidome of 53 patients at WHO stages 6–8 and 66 at WHO stages 1–3 COVID-19 disease was analysed using capillary electrophoresis coupled to mass spectrometry. 593 peptides were identified significantly affected by disease severity. These peptides were compared with changes associated with kidney disease or heart failure. Similarities with kidney disease were observed, indicating comparable molecular mechanisms. In contrast, convincing similarity to heart failure could not be detected. The data for the first time showed deregulation of CD99 and polymeric immunoglobulin receptor peptides and of known peptides associated with kidney disease, including collagen and alpha-1-antitrypsin. Peptidomic findings were in line with the pathophysiology of COVID-19. The clinical corollary is that COVID-19 induces specific inflammation of numerous tissues including endothelial lining. Restoring these changes, especially in CD99, PIGR and alpha-1-antitripsin, may represent a valid and effective therapeutic approach in COVID-19, targeting improvement of endothelial integrity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- CD99
- COVID-19
- endothelial disease
- heart failure
- kidney disease
- PIGR
Publication and Content Type
- ref (subject category)
- art (subject category)
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Siwy, Justyna
- Wendt, Ralph
- Albalat, Amaya
- He, Tianlin
- Mischak, Harald
- Mullen, William
- show more...
- Latosinska, Agni ...
- Lübbert, Christo ...
- Kalbitz, Sven
- Mebazaa, Alexand ...
- Peters, Björn
- Stegmayr, Bernd, ...
- Spasovski, Goce
- Wiech, Thorsten
- Staessen, Jan A.
- Wolf, Johannes
- Beige, Joachim
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and General Practice
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Health Sciences
- and Public Health Gl ...
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Urology and Neph ...
- Articles in the publication
- Proteomics
- By the university
- Umeå University
- University of Gothenburg
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
