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Colon cancer patien...
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Gkekas, Ioannis,1981-Umeå universitet,Kirurgi
(author)
Colon cancer patients with mismatch repair deficiency are more likely to present as acute surgical cases
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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Elsevier,2021
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-187187
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-187187URI
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https://doi.org/10.1016/j.ejca.2021.07.027DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: The effect of the genetic imprint on the emergency presentation of colon cancer remains unclear. The disparity between tumours evolving along different carcinogenetic pathways has not been studied systematically. This retrospective multicenter cohort study evaluates the association between mismatch repair status and the risk for acute surgery of colon cancer.Patients and methods: A retrospective multicenter cohort study including in total 870 patients from three different countries. Scandinavian cohort (Finland and Sweden), including a total of 412 patients operated between January 1, 1995 and December 31, 2010, was validated against a cohort from the Czech Republic, including a total of 458 patients, operated between January 1, 2018 and December 31, 2019. The proficiency or deficiency of mismatch repair was determined by immunohistochemistry. Primary outcome was the risk for acute colon cancer surgery given as the Odds Ratio (OR) in the univariable and multivariable analyses. Acute colon cancer surgery was defined as surgery performed during the same hospital admission as when the diagnosis of colon cancer was made.Results: Of the 870 patients (399 females [46%]) included in the analyses, median age at surgery was 69 [interquartile range, 61–76] years, deficient Mismatch Repair (dMMR) status was found in 190 patients (22%), and 179 patients (21%) underwent acute surgery during the same hospital admission as when the diagnosis of colon cancer was made. In the Scandinavian cohort, a significant association between dMMR status and acute surgery was seen in both the univariable (OR 1.82, 95% CI 1.11–3.02, P = 0.017) and the multivariable (OR = 2.21, 95% CI 1.28–3.95, P = 0.005) analyses. This was confirmed in the Czech validation cohort in both the univariable (OR = 1.94, 95% CI 1.09–3.26, P = 0.022) and the multivariable (OR = 1.77, 95% CI 1.15–3.18, P = 0.021) analyses.Conclusion: This multicenter study reveals a strong association between acute colon cancer surgery and dMMR tumour status.
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Novotny, JanUmeå universitet,Kirurgi(Swepub:umu)jano0030
(author)
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Kaprio, TuomasDepartment of Gastrointestinal Surgery, University of Helsinki and Helsinki University Hospital, Finland
(author)
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Beilmann-Lehtonen, InesDepartment of Transplantation and Liver Surgery, University of Helsinki and Helsinki University Hospital, Finland
(author)
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Fabian, PavelDepartment of Oncological Pathology, Masaryk Memorial Cancer Institute, Brno, Czech Republic
(author)
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Edin, SofiaUmeå universitet,Patologi(Swepub:umu)soed0001
(author)
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Strigård, KarinUmeå universitet,Kirurgi(Swepub:umu)kast0065
(author)
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Svoboda, TomasDepartment of Oncology and Radiotherapy, Faculty Hospital Pilsen, Charles University, Prague, Czech Republic
(author)
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Hagström, JaanaDepartment of Pathology, University of Helsinki, Finland; Department of Oral Pathology and Radiology, University of Turku, Finland
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Barsova, LucieComprehensive Oncology Center, Liberec, Czech Republic
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Jirasek, TomasDepartment of Pathology, Liberec, Czech Republic
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Haglund, CajDepartment of Gastrointestinal Surgery, University of Helsinki and Helsinki University Hospital, Finland
(author)
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Palmqvist, RichardUmeå universitet,Patologi(Swepub:umu)ripa0001
(author)
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Gunnarsson, UlfUmeå universitet,Kirurgi(Swepub:umu)ulgu0014
(author)
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Umeå universitetKirurgi
(creator_code:org_t)
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In:European Journal of Cancer: Elsevier157, s. 1-90959-80491879-0852
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Gkekas, Ioannis, ...
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Novotny, Jan
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Kaprio, Tuomas
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Beilmann-Lehtone ...
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Fabian, Pavel
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Edin, Sofia
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Strigård, Karin
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Svoboda, Tomas
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Hagström, Jaana
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Barsova, Lucie
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Jirasek, Tomas
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Haglund, Caj
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Palmqvist, Richa ...
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Gunnarsson, Ulf
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