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  • Crowe-McAuliffe, Caillan (author)

Structural Basis for Bacterial Ribosome-Associated Quality Control by RqcH and RqcP

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • Cell Press,2021
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-187403
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-187403URI
  • https://doi.org/10.1016/j.molcel.2020.11.002DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • In all branches of life, stalled translation intermediates are recognized and processed by ribosome-associated quality control (RQC) pathways. RQC begins with the splitting of stalled ribosomes, leaving an unfinished polypeptide still attached to the large subunit. Ancient and conserved NEMF family RQC proteins target these incomplete proteins for degradation by the addition of C-terminal "tails.'' How such tailing can occur without the regular suite of translational components is, however, unclear. Using single-particle cryo-electron microscopy (EM) of native complexes, we show that C-terminal tailing in Bacillus subtilis is mediated by NEMF protein RqcH in concert with RqcP, an Hsp15 family protein. Our structures reveal how these factors mediate tRNA movement across the ribosomal 50S subunit to synthesize polypeptides in the absence of mRNA or the small subunit.

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  • Takada, HirakuUmeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Molekylär Infektionsmedicin, Sverige (MIMS)(Swepub:umu)hita0003 (author)
  • Murina, VictoriiaUmeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Molekylär Infektionsmedicin, Sverige (MIMS)(Swepub:umu)vimu0008 (author)
  • Polte, Christine (author)
  • Kasvandik, Sergo (author)
  • Tenson, Tanel (author)
  • Ignatova, Zoya (author)
  • Atkinson, Gemma C.Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)(Swepub:umu)geat0002 (author)
  • Wilson, Daniel N. (author)
  • Hauryliuk, Vasili,1980-Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Molekylär Infektionsmedicin, Sverige (MIMS),University of Tartu, Institute of Technology, Tartu, Estonia(Swepub:umu)vaha0006 (author)
  • Umeå universitetInstitutionen för molekylärbiologi (Medicinska fakulteten) (creator_code:org_t)

Related titles

  • In:Molecular Cell: Cell Press81:1, s. 115-126.e71097-27651097-4164

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