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Prolactin and risk ...
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Hathaway, Cassandra A.Department of Cancer Epidemiology, Moffitt Cancer Center, FL, Tampa, United States
(author)
Prolactin and risk of epithelial ovarian cancer
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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American Association for Cancer Research (AACR),2021
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-187455
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-187455URI
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https://doi.org/10.1158/1055-9965.EPI-21-0139DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Background: Prolactin is synthesized in the ovaries and may play a role in ovarian cancer etiology. One prior prospective study observed a suggestive positive association between prolactin levels and risk of ovarian cancer.Methods: Weconducted a pooled case-control study of 703 cases and 864 matched controls nested within five prospective cohorts. We used unconditional logistic regression to calculate adjusted odds ratios (OR) and 95% confidence intervals (CI) for the association between prolactin and ovarian cancer risk. We examined heterogeneity by menopausal status at blood collection, body mass index (BMI), age, and histotype.Results: Among women with known menopausal status, we observed a positive trend in the association between prolactin and ovarian cancer risk (Ptrend = 0.045; OR, quartile 4 vs. 1 = 1.34; 95% CI = 0.97–1.85), but no significant association was observed for premenopausal or postmenopausal women individually (corresponding OR = 1.38; 95% CI = 0.74–2.58; Ptrend = 0.32 and OR = 1.41; 95% CI = 0.93–2.13; Ptrend = 0.08, respectively; Pheterogeneity = 0.91). In stratified analyses, we observed a positive association between prolactin and risk for women with BMI ≥ 25 kg/m2, but not BMI < 25 kg/m2 (corresponding OR = 2.68; 95% CI = 1.56–4.59; Ptrend < 0.01 and OR = 0.90; 95% CI = 0.58–1.40; Ptrend = 0.98, respectively; Pheterogeneity < 0.01). Associations did not vary by age, postmenopausal hormone therapy use, histotype, or time between blood draw and diagnosis.Conclusions: We found a trend between higher prolactin levels and increased ovarian cancer risk, especially among women with a BMI ≥ 25 kg/m2.Impact: This work supports a previous study linking higher prolactin with ovarian carcinogenesis in a high adiposity setting. Future work is needed to understand the mechanism underlying this association.
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Rice, Megan S.Clinical and Translational Epidemiology Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, MA, Boston, United States
(author)
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Townsend, Mary K.Department of Cancer Epidemiology, Moffitt Cancer Center, FL, Tampa, United States
(author)
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Hankinson, Susan E.Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, MA, Amherst, United States
(author)
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Arslan, Alan A.Department of Obstetrics and Gynecology, New York University Langone Health, NY, New York, United States; Department of Population Health, New York University Langone Health, NY, New York, United States; NYU Perlmutter Comprehensive Cancer Center, NY, New York, United States
(author)
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Buring, Julie E.Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
(author)
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Hallmans, Göran,1947-Umeå universitet,Näringsforskning(Swepub:umu)goha0001
(author)
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Idahl, Annika,1965-Umeå universitet,Obstetrik och gynekologi(Swepub:umu)anid0002
(author)
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Kubzansky, Laura D.Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
(author)
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Lee, I-MinDivision of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
(author)
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Lundin, EvaUmeå universitet,Patologi(Swepub:umu)evlu0001
(author)
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Sluss, Patrick M.Department of Pathology, Massachusetts General Hospital, MA, Boston, United States
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Zeleniuch-Jacquotte, AnneDepartment of Population Health, New York University Langone Health, NY, New York, United States; NYU Perlmutter Comprehensive Cancer Center, NY, New York, United States
(author)
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Tworoger, Shelley S.Department of Cancer Epidemiology, Moffitt Cancer Center, FL, Tampa, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
(author)
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Department of Cancer Epidemiology, Moffitt Cancer Center, FL, Tampa, United StatesClinical and Translational Epidemiology Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, MA, Boston, United States
(creator_code:org_t)
Related titles
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In:Cancer Epidemiology, Biomarkers and Prevention: American Association for Cancer Research (AACR)30:9, s. 1652-16591055-99651538-7755
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