Search: onr:"swepub:oai:DiVA.org:umu-187586" >
Evaluating oral and...
Evaluating oral and inhalation bioaccessibility of indoor dust-borne short- and median-chain chlorinated paraffins using in vitro Tenax-assisted physiologically based method
-
Du, Xinyu (author)
-
Zhou, Yihui (author)
-
Li, Jun (author)
-
show more...
-
Wu, Yan (author)
-
- Zheng, Ziye, 1992- (author)
- Umeå universitet,Kemiska institutionen
-
Yin, Ge (author)
-
Qiu, Yanling (author)
-
Zhao, Jianfu (author)
-
Yuan, Guoli (author)
-
show less...
-
(creator_code:org_t)
- Elsevier, 2021
- 2021
- English.
-
In: Journal of Hazardous Materials. - : Elsevier. - 0304-3894 .- 1873-3336. ; 402
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Though ingestion and inhalation of dust have been suggested as important exposure routes contributing chlorinated paraffins (CPs) build-up in humans, the bioaccessibility of dust-borne CPs in the organ environment has not been well-studied, which may hinder an accurate estimation of exposure risks. In this study, the ingestion and inhalation bioaccessibility of dust-borne shortand median-chain CPs (SCCPs and MCCPs) was assessed using (colon-extended) physiologically based extraction test with the addition of Tenax. The ingestion bioaccessibility of SCCPs 51.5 %Cl, SCCPs 63 %Cl, MCCPs 42 %Cl, and MCCPs 57 %Cl was in ranges of 21.1-44.0 %, 11.7-45.8 %, 21.9-36.6 %, and 7.9-32.9 %, respectively. Multiple linear regression analysis demonstrated statistically significant associations of ingestion bioaccessibility with carbon chain length and chlorine substitution. The ingestion bioaccessibility of CPs also increased with co-existence of carbohydrate/protein. The inhalation bioaccessibility of SCCPs (16.7-38.7 % in artificial lysosomal fluid and 15.5-34.1 % in modified Gamble solution) was significantly higher than MCCPs (< 5 %), and varied with dust particle size/total organic carbon content. Our study indicates that modest bioaccessible fractions of CPs in dust should be taken into account to refine the estimation of human exposure, and their bioaccessibility may be affected by CP molecular size, nutritional content and dust property.
Subject headings
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
Keyword
- SCCPs
- MCCPs
- Tenax
- Oral exposure
- In vitro
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Du, Xinyu
-
Zhou, Yihui
-
Li, Jun
-
Wu, Yan
-
Zheng, Ziye, 199 ...
-
Yin, Ge
-
show more...
-
Qiu, Yanling
-
Zhao, Jianfu
-
Yuan, Guoli
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Chemical Science ...
-
and Physical Chemist ...
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Earth and Relate ...
-
and Environmental Sc ...
- Articles in the publication
-
Journal of Hazar ...
- By the university
-
Umeå University