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3D imaging of human organs with micrometer resolution - applied to the endocrine pancreas

Hahn, Max (author)
Umeå universitet,Umeå centrum för molekylär medicin (UCMM),Umeå Univ, Umeå Ctr Mol Med, Umeå, Sweden.
Nord, Christoffer (author)
Umeå universitet,Umeå centrum för molekylär medicin (UCMM),Umeå Univ, Umeå Ctr Mol Med, Umeå, Sweden.
Eriksson, Maria (author)
Umeå universitet,Umeå centrum för molekylär medicin (UCMM),Umeå Univ, Umeå Ctr Mol Med, Umeå, Sweden.
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Morini, Federico (author)
Umeå universitet,Umeå centrum för molekylär medicin (UCMM),Umeå Univ, Umeå Ctr Mol Med, Umeå, Sweden.
Alanentalo, Tomas (author)
Umeå universitet,Umeå centrum för molekylär medicin (UCMM),Umeå Univ, Umeå Ctr Mol Med, Umeå, Sweden.
Korsgren, Olle (author)
Uppsala universitet,Klinisk immunologi
Ahlgren, Ulf (author)
Umeå universitet,Umeå centrum för molekylär medicin (UCMM),Umeå Univ, Umeå Ctr Mol Med, Umeå, Sweden.
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 (creator_code:org_t)
2021-09-10
2021
English.
In: Communications Biology. - : Springer Nature. - 2399-3642. ; 4:1
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • The possibility to quantitatively study specific molecular/cellular features of complete human organs with preserved spatial 3D context would have widespread implications for pre-clinical and clinical medicine. Whereas optical 3D imaging approaches have experienced a formidable revolution, they have remained limited due to current incapacities in obtaining specific labelling within large tissue volumes. We present a simple approach enabling reconstruction of antibody labeled cells within entire human organs with preserved organ context. We demonstrate the utility of the approach by providing volumetric data and 3D distribution of hundreds of thousands of islets of Langerhans within the human pancreas. By assessments of pancreata from non-diabetic and type 2 diabetic individuals, we display previously unrecognized features of the human islet mass distribution and pathology. As such, this method may contribute not only in unraveling new information of the pancreatic anatomy/pathophysiology, but it may be translated to essentially any antibody marker or organ system.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

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