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Obstructive sleep a...
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Sahlin, Carin,1953-Umeå universitet,Lungmedicin
(author)
Obstructive sleep apnea is a risk factor for death in patients with stroke : a 10-year follow-up
- Article/chapterEnglish2008
Publisher, publication year, extent ...
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Chicago :American medical association,2008
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Numbers
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LIBRIS-ID:oai:DiVA.org:umu-18814
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-18814URI
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https://doi.org/10.1001/archinternmed.2007.70DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:116547019URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: Sleep apnea occurs frequently among stroke patients, but it is still unknown whether a diagnosis of sleep apnea is an independent risk factor for mortality. We aimed to investigate whether obstructive or central sleep apnea was related to a reduced long-term survival among stroke patients.Methods: One hundred and thirty-two of 151 patients admitted for in-hospital stroke rehabilitation in the catchment area of Umeå from 1 April 1995 to 1 May 1997 underwent overnight sleep apnea recordings at 23 ± 8 days after onset of stroke. All patients were followed-up prospectively for a mean (SD) of 10.0 ± 0.6 years, with death as the primary outcome and no one was lost to follow-up. Obstructive sleep apnea was defined when the obstructive apnea-hypopnea index was over 15 and central sleep apnea when the central apnea-hypopnea index was over 15. Patients with an obstructive and a central apnea-hypopnea index below 15 served as controls.Results: Of 132 enrolled patients, 116 had died at follow-up. The risk of death was higher among the 23 patients with obstructive sleep apnea than controls (adjusted hazard ratio, 1.76; 95% confidence interval 1.05 to 2.95, p=0.03), independent of age, gender, body-mass index, smoking, hypertension, diabetes mellitus, atrial fibrillation, mini-mental state examination and Barthel activity of daily living There was no difference in mortality between the 28 patients with central sleep apnea and controls (adjusted hazard ratio, 1.07; 95 percent confidence interval 0.65 to 1.76, p=0.053).Conclusions: Stroke patients with obstructive sleep apnea run an increased risk of early death. Central sleep apnea was not related to early death among the present patients.
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Sandberg, OlovUmeå universitet,Geriatrik
(author)
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Gustafson, YngveUmeå universitet,Geriatrik(Swepub:umu)yngu0001
(author)
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Bucht, GöstaUmeå universitet,Geriatrik(Swepub:umu)gubu0001
(author)
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Carlberg, BoUmeå universitet,Medicin(Swepub:umu)boca0001
(author)
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Stenlund, HansUmeå universitet,Epidemiologi och folkhälsovetenskap(Swepub:umu)hast0001
(author)
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Franklin, KarlUmeå universitet,Lungmedicin(Swepub:umu)kafr0021
(author)
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Umeå universitetLungmedicin
(creator_code:org_t)
Related titles
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In:Archives of Internal MedicineChicago : American medical association168:3, s. 297-3010003-99261538-3679
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