Circulating tissue polypeptide-specific antigen in pre-diagnostic pancreatic cancer samples

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Borgmästars, EmmyUmeå universitet,Kirurgi (author)

Circulating tissue polypeptide-specific antigen in pre-diagnostic pancreatic cancer samples

Article/chapterEnglish2021

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2021-10-23
MDPI,2021
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:umu-188952
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-188952URI
https://doi.org/10.3390/cancers13215321DOI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Early detection of pancreatic ductal adenocarcinoma (PDAC) is challenging, and late diagnosis partly explains the low 5-year survival. Novel and sensitive biomarkers are needed to enable early PDAC detection and improve patient outcomes. Tissue polypeptide specific antigen (TPS) has been studied as a biomarker in PDAC diagnostics, and it has previously been shown to reflect clinical status better than the ‘golden standard’ biomarker carbohydrate antigen 19-9 (CA 19-9) that is most widely used in the clinical setting. In this cross-sectional case-control study using pre-diagnostic plasma samples, we aim to evaluate the potential of TPS as a biomarker for early PDAC detection. Furthermore, in a subset of individuals with multiple samples available at different time points before diagnosis, a longitudinal analysis was used. We assessed plasma TPS levels using enzyme-linked immunosorbent assay (ELISA) in 267 pre-diagnostic PDAC plasma samples taken up to 18.8 years before clinical PDAC diagnosis and in 320 matched healthy controls. TPS levels were also assessed in 25 samples at PDAC diagnosis. Circulating TPS levels were low both in pre-diagnostic samples of future PDAC patients and in healthy controls, whereas TPS levels at PDAC diagnosis were significantly increased (odds ratio 1.03; 95% confidence interval: 1.01–1.05) in a logistic regression model adjusted for age. In conclusion, TPS levels increase late in PDAC progression and hold no potential as a biomarker for early detection.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Gastroenterologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Gastroenterology and Hepatology hsv//eng
Circulating biomarkers
Early detection
Pancreatic ductal adenocarcinoma
Pre-diagnostic cohort
TPS

Added entries (persons, corporate bodies, meetings, titles ...)

Lundberg, Erik,1975-Umeå universitet,Kirurgi(Swepub:umu)erlu0002 (author)
Öhlund, Daniel,1979-Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi(Swepub:umu)dalohd00 (author)
Nyström, Hanna,1980-Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Kirurgi(Swepub:umu)haanym01 (author)
Franklin, Oskar,1985-Umeå universitet,Kirurgi(Swepub:umu)osfr0002 (author)
Lundin, Christina,1970-Umeå universitet,Kirurgi(Swepub:umu)chlu0008 (author)
Jonsson, PärUmeå universitet,Kemiska institutionen(Swepub:umu)parjon95 (author)
Sund, MalinUmeå universitet,Kirurgi,Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland(Swepub:umu)masu0021 (author)
Umeå universitetKirurgi (creator_code:org_t)

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In:Cancers: MDPI13:212072-6694

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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