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Comparative patholo...
Comparative pathology of dog and human prostate cancer
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- Ryman-Tubb, Toby (author)
- University of Nottingham, Nottingham, UK
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- Lothion-Roy, Jennifer H. (author)
- University of Nottingham, Nottingham, UK
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- Metzler, Veronika M. (author)
- University of Nottingham, Nottingham, UK
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- Harris, Anna E. (author)
- University of Nottingham, Nottingham, UK
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- Robinson, Brian D. (author)
- Weill Cornell Medicine, NY, New York, USA
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- Rizvanov, Albert A. (author)
- University of Nottingham, Nottingham, UK; Kazan Federal University, Kazan, Tatarstan, Russia
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- Jeyapalan, Jennie N. (author)
- University of Nottingham, Nottingham, UK
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- James, Victoria H. (author)
- University of Nottingham, Nottingham, UK
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- England, Gary (author)
- University of Nottingham, Nottingham, UK
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- Rutland, Catrin S. (author)
- University of Nottingham, Nottingham, UK
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- Persson, Jenny L., Professor (author)
- Malmö universitet,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Department of Biomedical Sciences, Malmö Universitet, Malmö, Sweden,Institutionen för biomedicinsk vetenskap (BMV),Umeå Universitet, Umeå, Sweden
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- Kenner, Lukas (author)
- Laboratory Animal Pathology Medical University Wien, Vienna, Austria
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- Rubin, Mark A. (author)
- University of Bern and Inselspital, Bern, Switzerland
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- Mongan, Nigel P. (author)
- University of Nottingham, Nottingham, UK; Weill Cornell Medicine, New York, New York, USA
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- de Brot, Simone (author)
- University of Nottingham, Nottingham, UK; University of Bern, Bern, Switzerland
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(creator_code:org_t)
- 2021-10-10
- 2022
- English.
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In: Veterinary medicine and science. - : John Wiley & Sons. - 2053-1095. ; 8:1, s. 110-120
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Abstract
Subject headings
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- Though relatively rare in dogs, prostate cancer (PCa) is the most common non-cutaneous cancer in men. Human and canine prostate glands share many functional, anatomical and physiological features. Due to these similarities, canine PCa has been proposed as a model for PCa in men. PCa is typically androgen-dependent at diagnosis in men and for this reason, androgen deprivation therapies (ADT) are important treatments for advanced PCa in men. In contrast, there is some evidence that PCa is diagnosed more commonly in castrate dogs, at which point, limited therapeutic options are available. In men, a major limitation of current ADT is that progression to a lethal and incurable form of PCa, termed castrate-resistant prostate cancer (CRPC), is common. There is, therefore, an urgent need for a better understanding of the mechanism of PCa initiation and progression to CRPC to enable the development of novel therapeutic approaches. This review focuses on the functional, physiological, endocrine and histopathological similarities and differences in the prostate gland of these species. In particular, we focus on common physiological roles for androgen signalling in the prostate of men and dogs, we review the short- and longer-term effects of castration on PCa incidence and progression in the dog and relate how this knowledge may be relevant to understanding the mechanisms of CRPC in men.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- adenocarcinoma
- animal model
- canine
- neuroendocrine
- urology
- Clinical Genetics
- klinisk genetik
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ryman-Tubb, Toby
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Lothion-Roy, Jen ...
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Metzler, Veronik ...
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Harris, Anna E.
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Robinson, Brian ...
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Rizvanov, Albert ...
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show more...
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Jeyapalan, Jenni ...
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James, Victoria ...
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England, Gary
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Rutland, Catrin ...
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Persson, Jenny L ...
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Kenner, Lukas
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Rubin, Mark A.
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Mongan, Nigel P.
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de Brot, Simone
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Veterinary medic ...
- By the university
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Umeå University
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Malmö University