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Milk intake and inc...
Milk intake and incident stroke and coronary heart disease in populations of European descent : a mendelian randomization study
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- Vissers, L.E.T. (author)
- Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, University Utrecht, Utrecht, Netherlands
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- Sluijs, I. (author)
- Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, University Utrecht, Utrecht, Netherlands
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- Burgess, S. (author)
- Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom,German Center for Diabetes Research,German Institute of Human Nutrition,University of Potsdam
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- Forouhi, N.G. (author)
- MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
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- Freisling, H. (author)
- International Agency for Research on Cancer, Lyon, France,International Agency for Research on Cancer, World Health Organization
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- Imamura, F. (author)
- MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
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- Nilsson, Torbjörn K. (author)
- Umeå University,Umeå universitet,Klinisk kemi
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- Renström, Frida (author)
- Umeå University,Umeå universitet,Enheten för biobanksforskning,Division of Endocrinology and Diabetes, Cantonal Hospital St. Gallen, St. Gallen, Switzerland,Kantonsspital St Gallen
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- Weiderpass, E. (author)
- International Agency for Research on Cancer, Lyon, France,International Agency for Research on Cancer, World Health Organization
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- Aleksandrova, K. (author)
- Germany Institute of Nutritional Sciences, University of Potsdam, Nuthetal, Germany
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- Dahm, C.C. (author)
- Department of Public Health, Aarhus University, Aarhus, Denmark,University of Murcia,CIBER Epidemiology and Public Health (CIBERESP)
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- Perez-Cornago, A. (author)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Schulze, M.B. (author)
- German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Germany Institute of Nutritional Sciences, University of Potsdam, Nuthetal, Germany
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- Tong, T.Y.N. (author)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Aune, D. (author)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Nutrition, Bjørknes University College, Oslo, Norway; Department of Endocrinology Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway
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- Bonet, C. (author)
- Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain,Bellvitge University Hospital-IDIBELL
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- Boer, J.M.A. (author)
- National Institute for Public Health and the Environment, Bilthoven, Netherlands,National Institute for Public Health and the Environment (RIVM)
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- Boeing, H. (author)
- German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
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- Chirlaque, M.D. (author)
- Department of Epidemiology, Regional Health Council IMIB-Arrixaca, Murcia University, Murcia, Spain; CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain
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- Conchi, M.I. (author)
- Navarra Public Health Institute - IdiSNA, Pamplona, Spain; Research Network on Health Services in Chronic Diseases (REDISSEC), Pamplona, Spain,Health Services Research on Chronic Patients Network (REDISSEC)
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- Imaz, L. (author)
- Ministry of Health of the Basque Government, Public Health Division of Gipuzkoa Donostia-San Sebastian, Spain; Biodonostia Health Research Institute, Spain
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- Sánches, M. J. (author)
- German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany,University of Granada,CIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP)
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- Krogh, V. (author)
- Epidemiology and Prevention Unit, Fondazione IRCCS Instituto Nazionale Dei Tumori, Milano, Italy
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- Kyrø, C. (author)
- Danish Cancer Society Research Center, Copenhagen, Denmark
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- Masala, G. (author)
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research Prevention and Clinical Network - ISPRO, Florence, Italy
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- Melander, O. (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Overvad, K. (author)
- Department of Public Health, Aarhus University, Aarhus, Denmark; Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark
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- Panico, S. (author)
- Dipartemento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
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- Sánches, M.J. (author)
- CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Andalusian School of Public Health (EASP), Granada, Spain; Instituto de Investigación Biosanitaria de Granada, Granada, Spain; Universidad de Granada, Granada, Spain
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- Sonestedt, E. (author)
- Lund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups
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- Tjønneland, A. (author)
- Danish Cancer Society Research Center, Copenhagen, Denmark
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- Tzoulaki, I. (author)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Verschuren, W.M.M. (author)
- Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, University Utrecht, Utrecht, Netherlands; National Institute for Public Health and the Environment, Bilthoven, Netherlands,National Institute for Public Health and the Environment (RIVM)
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- Riboli, E. (author)
- School of Public Health, Imperial College, London, United Kingdom
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- Wareham, N.J. (author)
- MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
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- Danesh, J. (author)
- MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
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- Butterworth, A.S. (author)
- Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, United Kingdom
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- Van Der Schouw, Y.T. (author)
- Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, University Utrecht, Utrecht, Netherlands
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(creator_code:org_t)
- Cambridge University Press, 2022
- 2022
- English.
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In: British Journal of Nutrition. - : Cambridge University Press. - 0007-1145 .- 1475-2662. ; 128:9, s. 1789-1797
- Related links:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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Abstract
Subject headings
Close
- Higher milk intake has been associated with a lower stroke risk, but not with risk of coronary heart disease (CHD). Residual confounding or reverse causation cannot be excluded. Therefore, we estimated the causal association of milk consumption with stroke and CHD risk through instrumental variable (IV) and gene-outcome analyses. IV analysis included 29,328 participants (4,611 stroke; 9,828 CHD) of the EPIC-CVD (8 European countries) and EPIC-NL case-cohort studies. rs4988235, a lactase persistence (LP) single nucleotide polymorphism which enables digestion of lactose in adulthood was used as genetic instrument. Intake of milk was first regressed on rs4988235 in a linear regression model. Next, associations of genetically predicted milk consumption with stroke and CHD were estimated using Prentice-weighted Cox regression. Gene-outcome analysis included 777,024 participants (50,804 cases) from MEGASTROKE (including EPIC-CVD), UK Biobank and EPIC-NL for stroke, and 483,966 participants (61,612 cases) from CARDIoGRAM, UK Biobank and EPIC-CVD and EPIC-NL for CHD. In IV analyses, each additional LP allele was associated with a higher intake of milk in EPIC-CVD (β=13.7 g/day; 95%CI: 8.4-19.1) and EPIC-NL (36.8 g/day; 20.0-53.5). Genetically predicted milk intake was not associated with stroke (HR per 25 g/day 1.05; 95%CI: 0.94-1.16) or CHD (1.02; 0.96-1.08). In gene-outcome analyses, there was no association of rs4988235 with risk of stroke (odds ratios 1.02; 0.99-1.05) or CHD (0.99; 0.95-1.03). Current Mendelian Randomization analysis does not provide evidence for a causal inverse relationship between milk consumption and stroke or CHD risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- CHD
- dairy
- Mendelian Randomization
- Milk
- stroke
- CHD
- dairy
- Mendelian Randomization
- Milk
- stroke
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Vissers, L.E.T.
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Sluijs, I.
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Burgess, S.
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Forouhi, N.G.
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Freisling, H.
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Imamura, F.
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show more...
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Nilsson, Torbjör ...
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Renström, Frida
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Weiderpass, E.
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Aleksandrova, K.
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Dahm, C.C.
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Perez-Cornago, A ...
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Schulze, M.B.
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Tong, T.Y.N.
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Aune, D.
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Bonet, C.
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Boer, J.M.A.
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Boeing, H.
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Chirlaque, M.D.
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Conchi, M.I.
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Imaz, L.
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Sánches, M. J.
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Krogh, V.
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Kyrø, C.
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Masala, G.
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Melander, O.
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Overvad, K.
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Panico, S.
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Sánches, M.J.
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Sonestedt, E.
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Tjønneland, A.
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Tzoulaki, I.
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Verschuren, W.M. ...
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Riboli, E.
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Wareham, N.J.
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Danesh, J.
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Butterworth, A.S ...
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Van Der Schouw, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
- Articles in the publication
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British Journal ...
- By the university
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Umeå University
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Lund University