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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00010759naa a2200829 4500
001oai:DiVA.org:umu-190814
003SwePub
008211229s2021 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1908142 URI
0247 a https://doi.org/10.1186/s12916-021-02183-22 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a His, Mathildeu International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, 150 cours Albert Thomas, Lyon CEDEX 08, France4 aut
2451 0a Lifestyle correlates of eight breast cancer-related metabolites :b a cross-sectional study within the EPIC cohort
264 c 2021-12-10
264 1b BioMed Central,c 2021
338 a electronic2 rdacarrier
520 a Background: Metabolomics is a promising molecular tool for identifying novel etiological pathways leading to cancer. In an earlier prospective study among pre- and postmenopausal women not using exogenous hormones, we observed a higher risk of breast cancer associated with higher blood concentrations of one metabolite (acetylcarnitine) and a lower risk associated with higher blood concentrations of seven others (arginine, asparagine, phosphatidylcholines (PCs) aa C36:3, ae C34:2, ae C36:2, ae C36:3, and ae C38:2).Methods: To identify determinants of these breast cancer-related metabolites, we conducted a cross-sectional analysis to identify their lifestyle and anthropometric correlates in 2358 women, who were previously included as controls in case-control studies nested within the European Prospective Investigation into Cancer and Nutrition cohort and not using exogenous hormones at blood collection. Associations of each metabolite concentration with 42 variables were assessed using linear regression models in a discovery set of 1572 participants. Significant associations were evaluated in a validation set (n = 786).Results: For the metabolites previously associated with a lower risk of breast cancer, concentrations of PCs ae C34:2, C36:2, C36:3, and C38:2 were negatively associated with adiposity and positively associated with total and saturated fat intakes. PC ae C36:2 was also negatively associated with alcohol consumption and positively associated with two scores reflecting adherence to a healthy lifestyle. Asparagine concentration was negatively associated with adiposity. Arginine and PC aa C36:3 concentrations were not associated to any of the factors examined. For the metabolite previously associated with a higher risk of breast cancer, acetylcarnitine, a positive association with age was observed.Conclusions: These associations may indicate possible mechanisms underlying associations between lifestyle and anthropometric factors, and risk of breast cancer. Further research is needed to identify potential non-lifestyle correlates of the metabolites investigated.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
653 a Anthropometry
653 a Breast cancer
653 a Cross-sectional
653 a Lifestyle
653 a Metabolites
7001 a Viallon, Vivianu International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, 150 cours Albert Thomas, Lyon CEDEX 08, France4 aut
7001 a Dossus, Laureu International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, 150 cours Albert Thomas, Lyon CEDEX 08, France4 aut
7001 a Schmidt, Julie A.u Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom4 aut
7001 a Travis, Ruth C.u Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom4 aut
7001 a Gunter, Marc J.u International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, 150 cours Albert Thomas, Lyon CEDEX 08, France4 aut
7001 a Overvad, Kimu Department of Public Health, Aarhus University, Aarhus, Denmark4 aut
7001 a Kyrø, Cecilieu Danish Cancer Society Research Center, Copenhagen, Denmark4 aut
7001 a Tjønneland, Anneu Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, Section of Environmental Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark4 aut
7001 a Lécuyer, Lucieu Université Paris-Saclay, UVSQ, Inserm, CESP U1018, “Exposome and Heredity” team, Gustave Roussy, Villejuif, France4 aut
7001 a Rothwell, Joseph A.u Université Paris-Saclay, UVSQ, Inserm, CESP U1018, “Exposome and Heredity” team, Gustave Roussy, Villejuif, France4 aut
7001 a Severi, Gianlucau Université Paris-Saclay, UVSQ, Inserm, CESP U1018, “Exposome and Heredity” team, Gustave Roussy, Villejuif, France; Department of Statistics, Computer Science, Applications “G. Parenti”, University of Florence, Florence, Italy4 aut
7001 a Johnson, Theronu Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut
7001 a Katzke, Verenau Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut
7001 a Schulze, Matthias B.u Department of Molecular Epidemiology, German Institute of Human Nutrition, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany4 aut
7001 a Masala, Giovannau Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy4 aut
7001 a Sieri, Sabinau Epidemiology and Prevention Unit, Fondazione IRCCS Instituto Nazionale dei Tumori di Milano, Milan, Italy4 aut
7001 a Panico, Salvatoreu Dipartimento Di Medicina Clinica E Chirurgia, Federico Ii University, Naples, Italy4 aut
7001 a Tumino, Rosariou Cancer Registry and Histopathology Department, Provincial Health Authority (ASP 7) Ragusa, Ragusa, Italy4 aut
7001 a Macciotta, Alessandrau Department of Clinical and Biological Sciences, University of Turin, Turin, Italy4 aut
7001 a Boer, Jolanda M. A.u Center for Nutrition, Prevention, and Health Services, National Institute for Public Health and the Environment (RIVM), BA, Bilthoven, Netherlands4 aut
7001 a Monninkhof, Evelyn M.u Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands4 aut
7001 a Olsen, Karina Standahlu Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway4 aut
7001 a Nøst, Therese H.u Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway4 aut
7001 a Sandanger, Torkjel M.u Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway4 aut
7001 a Agudo, Antoniou Unit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, L’Hospitalet de Llobregat, Spain; Nutrition and Cancer Group; Epidemiology, Public Health, Cancer Prevention and Palliative Care Program; Bellvitge Biomedical Research Institute - IDIBELL, L’Hospitalet de Llobregat, Spain4 aut
7001 a Sánchez, Maria-Joseu Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain4 aut
7001 a Amiano, Pilaru Ministry of Health of the Basque Government, Sub-Directorate for Public Health and Addictions of Gipuzkoa, San Sebastián, Spain; Biodonostia Health Research Institute, Group of Epidemiology of Chronic and Communicable Diseases, San Sebastián, Spain; CIBER Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III (ISCIII), Madrid, Spain4 aut
7001 a Colorado-Yohar, Sandra M.u CIBER Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia4 aut
7001 a Ardanaz, Evau CIBER Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain4 aut
7001 a Vidman, Lindau Umeå universitet,Onkologi4 aut0 (Swepub:umu)livi0018
7001 a Winkvist, Annau Umeå universitet,Avdelningen för hållbar hälsa4 aut0 (Swepub:umu)anwi0332
7001 a Heath, Alicia K.u Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom4 aut
7001 a Weiderpass, Elisabeteu International Agency for Research on Cancer (IARC/WHO), Office of the Director, Lyon, France4 aut
7001 a Huybrechts, Ingeu International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, 150 cours Albert Thomas, Lyon CEDEX 08, France4 aut
7001 a Rinaldi, Sabinau International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, 150 cours Albert Thomas, Lyon CEDEX 08, France4 aut
7102 a International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, 150 cours Albert Thomas, Lyon CEDEX 08, Franceb Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom4 org
7730 t BMC Medicined : BioMed Centralg 19:1q 19:1x 1741-7015
8564 u https://doi.org/10.1186/s12916-021-02183-2y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1623448/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://bmcmedicine.biomedcentral.com/track/pdf/10.1186/s12916-021-02183-2
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-190814
8564 8u https://doi.org/10.1186/s12916-021-02183-2

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