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  • Ma, Lijun (author)

Association analysis of Krüppel-like factor 11 variants with type 2 diabetes in Pima Indians

  • Article/chapterEnglish2008

Publisher, publication year, extent ...

  • Chevy Chase :Endocrine society,2008
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-19087
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-19087URI
  • https://doi.org/10.1210/jc.2008-0546DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • CONTEXT: Krüppel-like factor 11 (KLF11) is a transcription factor of the zinc finger domain family that has been shown to regulate expression of the insulin gene. An initial study reported that a KLF11 variant predicting a Q62R was associated with type 2 diabetes (T2D) in French Caucasians; however, subsequent studies have failed to identify an association between this variant and T2D in subjects from a similar Northern-European ancestry. OBJECTIVE: We sought to determine whether the Q62R or other variants within KLF11 were associated with T2D in Pima Indians, a population with an extremely high prevalence of this disease.DESIGN, SETTING, AND SUBJECTS: KLF11 was sequenced in 24 Pima Indians to identify potentially novel variants. There were 18 variants genotyped in a family-based sample of 1337 Pima Indians to analyze the linkage disequilibrium pattern of this gene and identify representative variants. Four representative variants were further genotyped in a population-based sample of 3501 full-heritage Pima Indians for association analyses. Among these subjects, 413 had undergone metabolic studies when they were nondiabetic to measure traits that predict T2D.RESULTS: Neither the Q62R nor any other common variant in KLF11 was associated with T2D in the Pima population. In addition, no variant was associated with insulin secretion or insulin-stimulated glucose disposal rate.CONCLUSIONS: Common variation in KLF11 variation does not appear to influence the population-based risk for developing T2D among full-heritage Pima Indians. Thus, KLF11 is unlikely to play a major role in the etiology of T2D among this Native American population.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Hanson, Robert L (author)
  • Que, Lorem N (author)
  • Mack, Janel L (author)
  • Franks, Paul WUmeå universitet,Medicin(Swepub:umu)pafr0003 (author)
  • Infante, Aniello M (author)
  • Kobes, Sayuko (author)
  • Bogardus, Clifton (author)
  • Baier, Leslie J (author)
  • Umeå universitetMedicin (creator_code:org_t)

Related titles

  • In:Journal of Clinical Endocrinology and MetabolismChevy Chase : Endocrine society93:9, s. 3644-36490021-972X1945-7197

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