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Association analysi...
Association analysis of Krüppel-like factor 11 variants with type 2 diabetes in Pima Indians
- Article/chapterEnglish2008
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Chevy Chase :Endocrine society,2008
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LIBRIS-ID:oai:DiVA.org:umu-19087
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-19087URI
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https://doi.org/10.1210/jc.2008-0546DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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CONTEXT: Krüppel-like factor 11 (KLF11) is a transcription factor of the zinc finger domain family that has been shown to regulate expression of the insulin gene. An initial study reported that a KLF11 variant predicting a Q62R was associated with type 2 diabetes (T2D) in French Caucasians; however, subsequent studies have failed to identify an association between this variant and T2D in subjects from a similar Northern-European ancestry. OBJECTIVE: We sought to determine whether the Q62R or other variants within KLF11 were associated with T2D in Pima Indians, a population with an extremely high prevalence of this disease.DESIGN, SETTING, AND SUBJECTS: KLF11 was sequenced in 24 Pima Indians to identify potentially novel variants. There were 18 variants genotyped in a family-based sample of 1337 Pima Indians to analyze the linkage disequilibrium pattern of this gene and identify representative variants. Four representative variants were further genotyped in a population-based sample of 3501 full-heritage Pima Indians for association analyses. Among these subjects, 413 had undergone metabolic studies when they were nondiabetic to measure traits that predict T2D.RESULTS: Neither the Q62R nor any other common variant in KLF11 was associated with T2D in the Pima population. In addition, no variant was associated with insulin secretion or insulin-stimulated glucose disposal rate.CONCLUSIONS: Common variation in KLF11 variation does not appear to influence the population-based risk for developing T2D among full-heritage Pima Indians. Thus, KLF11 is unlikely to play a major role in the etiology of T2D among this Native American population.
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Hanson, Robert L
(author)
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Que, Lorem N
(author)
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Mack, Janel L
(author)
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Franks, Paul WUmeå universitet,Medicin(Swepub:umu)pafr0003
(author)
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Infante, Aniello M
(author)
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Kobes, Sayuko
(author)
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Bogardus, Clifton
(author)
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Baier, Leslie J
(author)
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Umeå universitetMedicin
(creator_code:org_t)
Related titles
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In:Journal of Clinical Endocrinology and MetabolismChevy Chase : Endocrine society93:9, s. 3644-36490021-972X1945-7197
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