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Sökning: onr:"swepub:oai:DiVA.org:umu-191168" > The upper respirato...

The upper respiratory tract of felids is highly susceptible to sars‐cov‐2 infection

Krüger, Nadine (författare)
Infection Biology Unit, German Primate Center, Göttingen, Germany
Rocha, Cheila (författare)
Infection Biology Unit, German Primate Center, Göttingen, Germany
Runft, Sandra (författare)
Department of Pathology, University of Veterinary Medicine, Foundation, Hannover, Germany
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Krüger, Johannes (författare)
Department of Pathology, University of Veterinary Medicine, Foundation, Hannover, Germany
Färber, Iris (författare)
Department of Pathology, University of Veterinary Medicine, Foundation, Hannover, Germany
Armando, Federico (författare)
Department of Pathology, University of Veterinary Medicine, Foundation, Hannover, Germany
Leitzen, Eva (författare)
Department of Pathology, University of Veterinary Medicine, Foundation, Hannover, Germany
Brogden, Graham (författare)
Department of Biochemistry, University of Veterinary Medicine, Foundation, Hannover, Germany; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine, Foundation, Hannover, Germany; Institute of Experimental Virology, TWINCORE, Center for Experimental and Clinical Infection Research Hannover, Hannover, Germany
Gerold, Gisa, 1979- (författare)
Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Institutionen för klinisk mikrobiologi,Department of Biochemistry, University of Veterinary Medicine, Foundation, Hannover, Germany; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine, Foundation, Hannover, Germany; Institute of Experimental Virology, TWINCORE, Center for Experimental and Clinical Infection Research Hannover, Hannover, Germany
Pöhlmann, Stefan (författare)
Infection Biology Unit, German Primate Center, Göttingen, Germany
Hoffmann, Markus (författare)
Infection Biology Unit, German Primate Center, Göttingen, Germany
Baumgärtner, Wolfgang (författare)
Department of Pathology, University of Veterinary Medicine, Foundation, Hannover, Germany
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 (creator_code:org_t)
2021-09-30
2021
Engelska.
Ingår i: International Journal of Molecular Sciences. - : MDPI. - 1661-6596 .- 1422-0067. ; 22:19
Relaterad länk:
https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
https://www.mdpi.com...
https://urn.kb.se/re...
https://doi.org/10.3...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Natural or experimental infection of domestic cats and virus transmission from humans to captive predatory cats suggest that felids are highly susceptible to SARS‐CoV‐2 infection. However, it is unclear which cells and compartments of the respiratory tract are infected. To address this question, primary cell cultures derived from the nose, trachea, and lungs of cat and lion were inoculated with SARS‐CoV‐2. Strong viral replication was observed for nasal mucosa explants and tracheal air–liquid interface cultures, whereas replication in lung slices was less efficient. Infection was mainly restricted to epithelial cells and did not cause major pathological changes. Detection of high ACE2 levels in the nose and trachea but not lung further suggests that susceptibility of feline tissues to SARS‐CoV‐2 correlates with ACE2 expression. Collectively, this study demonstrates that SARS‐ CoV‐2 can efficiently replicate in the feline upper respiratory tract ex vivo and thus highlights the risk of SARS‐CoV‐2 spillover from humans to felids.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)

Nyckelord

ACE2
Felines
Primary cell cultures
Respiratory tract
SARS‐CoV‐2

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