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  • Do, LanUmeå University,Umeå universitet,Reumatologi (author)

Anti-CD74 IgA autoantibodies in radiographic axial spondyloarthritis : a longitudinal Swedish study

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2020-12-28
  • Oxford University Press,2021
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-191231
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191231URI
  • https://doi.org/10.1093/rheumatology/keaa882DOI
  • https://lup.lub.lu.se/record/db01ea10-de13-49e7-b1a9-9e65acff19b5URI
  • https://gup.ub.gu.se/publication/300688URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • OBJECTIVES: Antibodies against anti-CD74 are related to axial spondyloarthritis (axSpA). The objectives were (i) to study IgA anti-CD74 in radiographic (r)-axSpA patients in the Backbone cohort and to calculate the sensitivity and specificity of anti-CD74, (ii) to study the fluctuation of IgA anti-CD74 levels in prospectively collected samples, and (iii) to explore the relation between IgA anti-CD74 and radiographic spinal changes.METHODS: IgA anti-CD74 was analysed by ELISA in 155 patients with r-axSpA and age- and sex-matched controls. BASDAI, ASDAS, BASFI and BASMI were assessed and spinal radiographs were scored for r-axSpA-related changes with mSASSS. Previously donated samples, before inclusion in the Backbone study, were identified in the Medical Biobank of Northern Sweden.RESULTS: A total of 155 patients comprising 69% men and 31% women, age [mean (s.d.)] 55.5 (11.4) years and 152 (98.1%) HLA-B27 positive, were included. The plasma level of IgA anti-CD74 was significantly higher in the patients [median (interquartile range), 12.9 (7.9-17.9) U/ml] compared with controls [10.9 (7.2-14.6) U/ml, P = 0.003]. IgA anti-CD74 was above the cut-off level of 20 U/ml in 36/155 (23.2%) patients and in 15/151 (9.9%) controls (P = 0.002). Multivariable logistic regression analyses revealed ≥1 syndesmophyte associated with IgA anti-CD74 (odds ratio 5.64; 95% CI: 1.02, 35.58; P = 0.048) adjusted for hsCRP, smoking, BMI, sex and age. No distinct pattern of IgA anti-CD74 over time was revealed.CONCLUSION: Plasma levels of IgA anti-CD74 were increased in r-axSpA and independently associated with radiographic spinal changes, which suggests that IgA anti-CD74 could play a role in the pathogenies of r-axSpA.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Granåsen, Gabriel,1980-Umeå University,Umeå universitet,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)galgrn00 (author)
  • Hellman, Urban,1966-Umeå University,Umeå universitet,Reumatologi(Swepub:umu)urhe0001 (author)
  • Lejon, Kristina,1967-Umeå University,Umeå universitet,Immunologi/immunkemi(Swepub:umu)krle0001 (author)
  • Geijer, MatsLund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Sahlgrenska University Hospital,Sahlgrenska Academy(Swepub:lu)med-mge (author)
  • Baraliakos, XenofonDepartment of Biochemistry, Ruhr-Universität Bochum, Bochum, Germany (author)
  • Witte, TorstenDepartment of Rheumatology and Clinical Immunology, Medical University Hannover, Hannover, Germany,Hannover Medical School (author)
  • Forsblad-d'Elia, HelenaGothenburg University,Göteborgs universitet,Umeå University,Umeå universitet,Reumatologi,Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Rheumatology, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xforhe (author)
  • Umeå universitetReumatologi (creator_code:org_t)

Related titles

  • In:Rheumatology: Oxford University Press60:9, s. 4085-40931462-03241462-03321310-0505

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