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Metabolic signature...
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Rothwell, Joseph A.Centre for Epidemiology and Population Health, U1018, Generations and Health Team, Faculté de Médecine, Université Paris-Saclay, INSERM, Villejuif, France; Gustave Roussy, Villejuif, France; International Agency for Research on Cancer, Lyon, France
(author)
Metabolic signatures of healthy lifestyle patterns and colorectal cancer risk in a European cohort
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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Elsevier,2022
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-191349
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191349URI
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https://doi.org/10.1016/j.cgh.2020.11.045DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background & Aims: Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.Methods: Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1–5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5738 cancer-free European Prospective Investigation into Cancer and Nutrition participants with metabolomics data. Partial least-squares regression was used to derive fatty acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and 95% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression.Results: Higher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95% CI, 0.29–0.90; endogenous metabolites: OR, 0.62 per unit change; 95% CI, 0.50–0.78) than the WCRF/AICR score (OR, 0.93 per unit change; 95% CI, 0.86–1.00) overall. Signature associations were stronger in male compared with female participants.Conclusions: Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.
Subject headings and genre
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Murphy, NeilInternational Agency for Research on Cancer, Lyon, France
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Bešević, JelenaDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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Kliemann, NathalieInternational Agency for Research on Cancer, Lyon, France
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Jenab, MazdaInternational Agency for Research on Cancer, Lyon, France
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Ferrari, PietroInternational Agency for Research on Cancer, Lyon, France
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Achaintre, DavidInternational Agency for Research on Cancer, Lyon, France
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Gicquiau, AudreyInternational Agency for Research on Cancer, Lyon, France
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Vozar, BéatriceInternational Agency for Research on Cancer, Lyon, France
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Scalbert, AugustinInternational Agency for Research on Cancer, Lyon, France
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Huybrechts, IngeInternational Agency for Research on Cancer, Lyon, France
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Freisling, HeinzInternational Agency for Research on Cancer, Lyon, France
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Prehn, CorneliaDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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Adamski, JerzyResearch Unit, Molecular Endocrinology and Metabolism, Helmholtz Zentrum München, Neuherberg, Germany; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Experimental Genetics, School of Life Science Weihenstephan, Technische Universität München, Neuherberg, Germany
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Cross, Amanda J.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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Pala, Valeria MariaDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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Boutron-Ruault, Marie-ChristineCentre for Epidemiology and Population Health, U1018, Generations and Health Team, Faculté de Médecine, Université Paris-Saclay, INSERM, Villejuif, France; Gustave Roussy, Villejuif, France
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Dahm, Christina C.Department of Public Health, Aarhus University, Aarhus C, Denmark
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Overvad, KimDepartment of Public Health, Aarhus University, Aarhus C, Denmark
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Gram, Inger TorhildFaculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
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Sandanger, Torkjel M.Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
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Skeie, GuriFaculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
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Jakszyn, PaulaUnit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, Barcelona, Spain; Blanquerna School of Health Sciences, Ramon Llull University, Barcelona, Spain
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Tsilidis, Kostas K.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
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Aleksandrova, KrasimiraNutrition, Immunity and Metabolism Group, Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
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Schulze, Matthias B.Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
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Hughes, David J.School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin, Ireland
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van Guelpen, BethanyUmeå universitet,Onkologi(Swepub:umu)beyvan99
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Bodén, StinaUmeå universitet,Onkologi(Swepub:umu)stabon98
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Sánchez, Maria-JoséCIBER Epidemiología y Salud Pública, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
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Schmidt, Julie A.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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Katzke, VerenaDivision of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Stiftung des Öffentlichen Rechts, Heidelberg, Germany
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Kühn, TilmanDivision of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Stiftung des Öffentlichen Rechts, Heidelberg, Germany
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Colorado-Yohar, SandraDepartment of Epidemiology, Murcia Regional Health Council, Instituto Murciano de Investigatión Biomédica (IMIB)–Arrixaca, Murcia, Spain; CIBER Epidemiología y Salud Pública, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia
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Tumino, RosarioCancer Registry and Histopathology Department, Provincial Health Authority, Ragusa, Italy
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Bueno-de-Mesquita, BasDepartment for Determinants of Chronic Diseases, National Institute for Public Health and the Environment, The Netherlands, BA Bilthoven, Netherlands
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Vineis, PaoloDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Italian Institute of Technology, Genova, Italy
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Masala, GiovannaCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network–Istituto per lo Studio, la Prevenzione e la Rete Oncologica (ISPRO), Florence, Italy
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Panico, SalvatoreDipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
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Eriksen, Anne KirstineDanish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark
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Tjønneland, AnneDanish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark
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Aune, DagfinnDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Nutrition, Bjørknes University College, Oslo, Norway; Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway
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Weiderpass, ElisabeteInternational Agency for Research on Cancer, Lyon, France
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Severi, GianlucaCentre for Epidemiology and Population Health, U1018, Generations and Health Team, Faculté de Médecine, Université Paris-Saclay, INSERM, Villejuif, France; Gustave Roussy, Villejuif, France
(author)
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Chajès, VéroniqueInternational Agency for Research on Cancer, Lyon, France
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Gunter, Marc J.International Agency for Research on Cancer, Lyon, France
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Centre for Epidemiology and Population Health, U1018, Generations and Health Team, Faculté de Médecine, Université Paris-Saclay, INSERM, Villejuif, France; Gustave Roussy, Villejuif, France; International Agency for Research on Cancer, Lyon, FranceInternational Agency for Research on Cancer, Lyon, France
(creator_code:org_t)
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In:Clinical Gastroenterology and Hepatology: Elsevier20:5, s. e1061-e10821542-35651542-7714
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Achaintre, David
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Prehn, Cornelia
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Adamski, Jerzy
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Dahm, Christina ...
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Overvad, Kim
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van Guelpen, Bet ...
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