SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:umu-191615"
 

Search: onr:"swepub:oai:DiVA.org:umu-191615" > Self-reported sleep...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Grydeland, Håkon (author)

Self-reported sleep relates to microstructural hippocampal decline in beta-amyloid positive Adults beyond genetic risk

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-04-28
  • Oxford University Press,2021
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-191615
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191615URI
  • https://doi.org/10.1093/sleep/zsab110DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Study Objectives: A critical role linking sleep with memory decay and beta-amyloid (A beta) accumulation, two markers of Alzheimer's disease (AD) pathology, may be played by hippocampal integrity. We tested the hypotheses that worse self-reported sleep relates to decline in memory and intra-hippocampal microstructure, including in the presence of A beta.Methods: Two-hundred and forty-three cognitively healthy participants, aged 19-81 years, completed the Pittsburgh Sleep Quality Index once, and two diffusion tensor imaging sessions, on average 3 years apart, allowing measures of decline in intra-hippocampal microstructure as indexed by increased mean diffusivity. We measured memory decay at each imaging session using verbal delayed recall. One session of positron emission tomography, in 108 participants above 44 years of age, yielded 23 A beta positive. Genotyping enabled control for APOE epsilon 4 status, and polygenic scores for sleep and AD, respectively.Results: Worse global sleep quality and sleep efficiency related to more rapid reduction of hippocampal microstructure over time. Focusing on efficiency (the percentage of time in bed at night spent asleep), the relation was stronger in presence of A beta accumulation, and hippocampal integrity decline mediated the relation with memory decay. The results were not explained by genetic risk for sleep efficiency or AD.Conclusions: Worse sleep efficiency related to decline in hippocampal microstructure, especially in the presence of A beta accumulation, and A beta might link poor sleep and memory decay. As genetic risk did not account for the associations, poor sleep efficiency might constitute a risk marker for AD, although the driving causal mechanisms remain unknown.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Sederevicius, Donatas (author)
  • Wang, Yunpeng (author)
  • Bartres-Faz, David (author)
  • Bertram, Lars (author)
  • Dobricic, Valerija (author)
  • Duzel, Sandra (author)
  • Ebmeier, Klaus P. (author)
  • Lindenberger, Ulman (author)
  • Nyberg, Lars,1966-Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för strålningsvetenskaper,Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway(Swepub:umu)lany0001 (author)
  • Pudas, Sara,Docent,1983-Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för strålningsvetenskaper(Swepub:umu)saatus02 (author)
  • Sexton, Claire E. (author)
  • Sole-Padulles, Cristina (author)
  • Sørensen, Øystein (author)
  • Walhovd, Kristine B. (author)
  • Fjell, Anders M. (author)
  • Umeå universitetUmeå centrum för funktionell hjärnavbildning (UFBI) (creator_code:org_t)

Related titles

  • In:Sleep: Oxford University Press44:110161-81051550-9109

Internet link

Find in a library

  • Sleep (Search for host publication in LIBRIS)

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view