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Prospective evaluat...
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Mukama, TrasiasDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
(author)
Prospective evaluation of 92 serum protein biomarkers for early detection of ovarian cancer
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-01-14
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Springer Nature,2022
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-191667
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191667URI
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https://doi.org/10.1038/s41416-021-01697-zDOI
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https://lup.lub.lu.se/record/6fd53ff2-c965-4093-b3a6-a533a67787b9URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: CA125 is the best available yet insufficiently sensitive biomarker for early detection of ovarian cancer. There is a need to identify novel biomarkers, which individually or in combination with CA125 can achieve adequate sensitivity and specificity for the detection of earlier-stage ovarian cancer.Methods: In the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we measured serum levels of 92 preselected proteins for 91 women who had blood sampled ≤18 months prior to ovarian cancer diagnosis, and 182 matched controls. We evaluated the discriminatory performance of the proteins as potential early diagnostic biomarkers of ovarian cancer.Results: Nine of the 92 markers; CA125, HE4, FOLR1, KLK11, WISP1, MDK, CXCL13, MSLN and ADAM8 showed an area under the ROC curve (AUC) of ≥0.70 for discriminating between women diagnosed with ovarian cancer and women who remained cancer-free. All, except ADAM8, had shown at least equal discrimination in previous case-control comparisons. The discrimination of the biomarkers, however, was low for the lag-time of >9–18 months and paired combinations of CA125 with any of the 8 markers did not improve discrimination compared to CA125 alone.Conclusion: Using pre-diagnostic serum samples, this study identified markers with good discrimination for the lag-time of 0–9 months. However, the discrimination was low in blood samples collected more than 9 months prior to diagnosis, and none of the markers showed major improvement in discrimination when added to CA125.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Fortner, Renée TurzanskiDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
(author)
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Katzke, VerenaDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
(author)
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Hynes, Lucas CoryDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
(author)
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Petrera, AgneseResearch Unit Protein Science, Helmholtz Zentrum München, German Center for Environmental Health, Neuherberg, Germany
(author)
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Hauck, Stefanie M.Research Unit Protein Science, Helmholtz Zentrum München, German Center for Environmental Health, Neuherberg, Germany
(author)
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Johnson, TheronDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
(author)
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Schulze, MatthiasDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam -Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
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Schiborn, CatarinaDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam -Rehbruecke, Nuthetal, Germany
(author)
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Rostgaard-Hansen, Agnetha LinnDanish Cancer Society Research Center, Diet, Genes and Environment, Strandboulevarden 49 DK-2100, Copenhagen, Denmark
(author)
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Tjønneland, AnneDanish Cancer Society Research Center, Diet, Genes and Environment, Strandboulevarden 49 DK-2100, Copenhagen, Denmark
(author)
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Overvad, KimDepartment of Public Health, Aarhus University, Bartholins Alle 2, Aarhus C, Denmark
(author)
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Pérez, María José SánchezEscuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain,Andalusian School Of Public Health (EASP)
(author)
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Crous-Bou, MartaUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO) - Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States,Harvard University,Bellvitge University Hospital-IDIBELL
(author)
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Chirlaque, María-DoloresCIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Murcia, Spain
(author)
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Amiano, PilarCIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Ministry of Health of the Basque Government, Sub-Directorate for Public Health and Addictions of Gipuzkoa, San Sebastián, Spain; Biodonostia Health Research Institute, Group of Epidemiology of Chronic and Communicable Diseases, San Sebastián, Spain
(author)
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Ardanaz, EvaCIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain
(author)
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Watts, Eleanor L.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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Travis, Ruth C.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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Sacerdote, CarlottaUnit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, Via Santena 7, Turin, Italy
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Grioni, SaraEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy
(author)
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Masala, GiovannaInstitute of Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy
(author)
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Signoriello, SimonaDipartimento di Salute Mentale e Fisica e Medicina Preventiva, Vanvitelli University, Naples, Italy
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Tumino, RosarioCancer Registry and Histopathology Department, Provincial Health Authority (ASP 7), Ragusa, Italy
(author)
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Gram, Inger T.Faculty of Health Sciences, Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway
(author)
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Sandanger, Torkjel M.Faculty of Health Sciences, Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway
(author)
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Sartor, HannaLund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Radiology Diagnostics, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital(Swepub:lu)med-hso
(author)
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Lundin, EvaUmeå University,Umeå universitet,Patologi(Swepub:umu)evlu0001
(author)
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Idahl, Annika,1965-Umeå University,Umeå universitet,Obstetrik och gynekologi(Swepub:umu)anid0002
(author)
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Heath, Alicia K.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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Dossus, LaureNutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France
(author)
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Weiderpass, ElisabeteInternational Agency for Research on Cancer, World Health Organization, Lyon, France
(author)
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Kaaks, RudolfDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
(author)
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Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, GermanyResearch Unit Protein Science, Helmholtz Zentrum München, German Center for Environmental Health, Neuherberg, Germany
(creator_code:org_t)
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In:British Journal of Cancer: Springer Nature126, s. 1301-13090007-09201532-1827
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Mukama, Trasias
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Fortner, Renée T ...
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Katzke, Verena
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Hynes, Lucas Cor ...
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Petrera, Agnese
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Hauck, Stefanie ...
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Johnson, Theron
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Schulze, Matthia ...
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Schiborn, Catari ...
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Rostgaard-Hansen ...
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Tjønneland, Anne
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Overvad, Kim
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Pérez, María Jos ...
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Crous-Bou, Marta
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Chirlaque, María ...
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Amiano, Pilar
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Ardanaz, Eva
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Watts, Eleanor L ...
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Travis, Ruth C.
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Sacerdote, Carlo ...
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Grioni, Sara
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Masala, Giovanna
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Signoriello, Sim ...
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Tumino, Rosario
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Gram, Inger T.
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Sandanger, Torkj ...
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Sartor, Hanna
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Lundin, Eva
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Idahl, Annika, 1 ...
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Heath, Alicia K.
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Dossus, Laure
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Weiderpass, Elis ...
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Kaaks, Rudolf
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