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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00010392naa a2200745 4500
001oai:DiVA.org:umu-191737
003SwePub
008220124s2022 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1917372 URI
0247 a https://doi.org/10.1158/1055-9965.EPI-21-04632 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Borozan, Ivanu Ontario Institute for Cancer Research, ON, Toronto, Canada4 aut
2451 0a Molecular and Pathology Features of Colorectal Tumors and Patient Outcomes Are Associated with Fusobacterium nucleatum and Its Subspecies animalis
264 1b American Association for Cancer Research,c 2022
338 a print2 rdacarrier
520 a Background: Fusobacterium nucleatum (F. nucleatum) activates oncogenic signaling pathways and induces inflammation to promote colorectal carcinogenesis.Methods: We characterized F. nucleatum and its subspecies in colorectal tumors and examined associations with tumor characteristics and colorectal cancer-specific survival. We conducted deep sequencing of nusA, nusG, and bacterial 16s rRNA genes in tumors from 1,994 patients with colorectal cancer and assessed associations between F. nucleatum presence and clinical characteristics, colorectal cancer-specific mortality, and somatic mutations.Results: F. nucleatum, which was present in 10.3% of tumors, was detected in a higher proportion of right-sided and advanced-stage tumors, particularly subspecies animalis. Presence of F. nucleatum was associated with higher colorectal cancer-specific mortality (HR, 1.97; P = 0.0004). This association was restricted to nonhypermutated, microsatellite-stable tumors (HR, 2.13; P = 0.0002) and those who received chemotherapy [HR, 1.92; confidence interval (CI), 1.07-3.45; P = 0.029). Only F. nucleatum subspecies animalis, the main subspecies detected (65.8%), was associated with colorectal cancer-specific mortality (HR, 2.16; P = 0.0016), subspecies vincentii and nucleatum were not (HR, 1.07; P = 0.86). Additional adjustment for tumor stage suggests that the effect of F. nucleatum on mortality is partly driven by a stage shift. Presence of F. nucleatum was associated with microsatellite instable tumors, tumors with POLE exonuclease domain mutations, and ERBB3 mutations, and suggestively associated with TP53 mutations.Conclusions: F. nucleatum, and particularly subspecies animalis, was associated with a higher colorectal cancer-specific mortality and specific somatic mutated genes.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Zaidi, Syed H.u Ontario Institute for Cancer Research, ON, Toronto, Canada4 aut
7001 a Harrison, Tabitha A.u Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States4 aut
7001 a Phipps, Amanda I.u Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States4 aut
7001 a Zheng, Jiayinu Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States4 aut
7001 a Lee, Stephenu Ontario Institute for Cancer Research, ON, Toronto, Canada4 aut
7001 a Trinh, Quang M.u Ontario Institute for Cancer Research, ON, Toronto, Canada4 aut
7001 a Steinfelder, Robert S.u Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States4 aut
7001 a Adams, Jeremyu Ontario Institute for Cancer Research, ON, Toronto, Canada4 aut
7001 a Banbury, Barbara L.u Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States4 aut
7001 a Berndt, Sonja I.u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States4 aut
7001 a Brezina, Stefanieu Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria4 aut
7001 a Buchanan, Daniel D.u Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, VIC, Parkville, Australia; The University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, VIC, Parkville, Australia; Familial Cancer Clinic, Genetic Medicine, The Royal Melbourne Hospital, VIC, Parkville, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Parkville, Australia4 aut
7001 a Bullman, Susanu Human Biology Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut
7001 a Cao, Yinu Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St. Louis, St Louis, MO, United States; Siteman Cancer Center, Washington University School of Medicine in St. Louis, St Louis, MO, United States4 aut
7001 a Farris III, Alton B.u Pathology and Laboratory Medicine, Emory University, School of Medicine, GA, Atlanta, United States4 aut
7001 a Figueiredo, Jane C.u Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States4 aut
7001 a Giannakis, Mariosu Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, MA, Boston, United States; Broad Institute of MIT and Harvard, MA, Cambridge, United States4 aut
7001 a Heisler, Lawrence E.u Ontario Institute for Cancer Research, ON, Toronto, Canada4 aut
7001 a Hopper, John L.u The University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, VIC, Parkville, Australia4 aut
7001 a Lin, Yiu Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States4 aut
7001 a Luo, Xuemeiu Ontario Institute for Cancer Research, ON, Toronto, Canada4 aut
7001 a Nishihara, Reikou Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, MA, Boston, United States; Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States4 aut
7001 a Mardis, Elaine R.u The Steve and Cindy Rasmussen Institute for Genomic Medicine, Abigail Wexner Research Institute, Nationwide Children's Hospital, OH, Columbus, United States4 aut
7001 a Papadopoulos, Nickolasu Ludwig Center for Cancer Genetics and Therapeutics, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine, MD, Baltimore, United States4 aut
7001 a Qu, Conghuiu Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States4 aut
7001 a Reid, Emma E.G.u Ontario Institute for Cancer Research, ON, Toronto, Canada4 aut
7001 a Thibodeau, Stephen N.u Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, MN, Rochester, United States4 aut
7001 a Harlid, Sophia,d 1978-u Umeå universitet,Onkologi4 aut0 (Swepub:umu)soha0105
7001 a Um, Caroline Y.u Behavioral and Epidemiology Research Group, American Cancer Society, GA, Atlanta, United States4 aut
7001 a Hsu, Liu Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States; Department of Biostatistics, School of Public Health, University of Washington, WA, Seattle, United States4 aut
7001 a Gsur, Andreau Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria4 aut
7001 a Campbell, Peter T.u Behavioral and Epidemiology Research Group, American Cancer Society, GA, Atlanta, United States4 aut
7001 a Gallinger, Stevenu Ontario Institute for Cancer Research, ON, Toronto, Canada; Lunenfeld-Tanenbaum Research Institute, Sinai Health, University of Toronto, ON, Toronto, Canada; General Surgery, Surgery and Critical Care Program, University Health Network Toronto General Hospital, University of Toronto, ON, Toronto, Canada4 aut
7001 a Newcomb, Polly A.u Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States; Department of Epidemiology, School of Public Health, University of Washington, WA, Seattle, United States4 aut
7001 a Ogino, Shujiu Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, MA, Boston, United States; Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Cancer Immunology Program, Dana-Farber/Harvard Cancer Center, MA, Boston, United States; Cancer Epidemiology Program, Dana-Farber/Harvard Cancer Center, MA, Boston, United States4 aut
7001 a Sun, Weiu Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States4 aut
7001 a Hudson, Thomas J.u Ontario Institute for Cancer Research, ON, Toronto, Canada4 aut
7001 a Ferretti, Vincentu Ontario Institute for Cancer Research, ON, Toronto, Canada; CHU Sainte-Justine Research Center, University of Montreal, QC, Montreal, Canada4 aut
7001 a Peters, Ulrikeu Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States; Department of Epidemiology, School of Public Health, University of Washington, WA, Seattle, United States4 aut
7102 a Ontario Institute for Cancer Research, ON, Toronto, Canadab Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, WA, Seattle, United States4 org
7730 t Cancer Epidemiology, Biomarkers and Preventiond : American Association for Cancer Researchg 31:1, s. 210-220q 31:1<210-220x 1055-9965x 1538-7755
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191737
8564 8u https://doi.org/10.1158/1055-9965.EPI-21-0463

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