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Antibodies against ...
Antibodies against mutated citrullinated vimentin are a better predictor of disease activity at 24 months in early rheumatoid arthritis than antibodies against cyclic citrullinated peptides
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- Innala, Lena (author)
- Umeå universitet,Reumatologi
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- Kokkonen, Heidi (author)
- Umeå universitet,Reumatologi
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- Eriksson, Catharina, 1955- (author)
- Umeå universitet,Klinisk immunologi
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- Jidell, Erik, 1955- (author)
- Umeå universitet,Klinisk immunologi
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- Berglin, Ewa, MD, PhD, 1955- (author)
- Umeå universitet,Reumatologi
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- Rantapää Dahlqvist, Solbritt (author)
- Umeå universitet,Reumatologi
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(creator_code:org_t)
- 2008
- 2008
- English.
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In: Journal of Rheumatology. - 0315-162X .- 1499-2752. ; 35:6, s. 1002-1008
- Related links:
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http://www.jrheum.or...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- OBJECTIVE: To evaluate the predictive values for disease progression of various antibodies against citrullinated peptide proteins (ACPA) and their relation to PTPN22 1858C/T polymorphism and HLA-DRB1 alleles in early rheumatoid arthritis (RA).METHODS: The ACPA, e.g., antibodies against mutated citrullinated vimentin (MCV), cyclic citrullinated peptides (CCP) type 2 and 3 (both of IgG isotype) and 3.1 (of both IgG and IgA isotypes), were analyzed at baseline in patients with early RA (n = 210) and in population controls (n = 102) using an enzyme immunoassay. A receiver-operating characteristic curve was constructed for each antibody. Disease activity [swollen and tender joints, visual analog scale for global health, and erythrocyte sedimentation rate (ESR)] was evaluated at baseline and regularly for 24 months. Radiographs of hands and feet were graded using the Larsen score.RESULTS: Patients with anti-MCV antibodies had significantly less reduction in Disease Activity Score (DAS28) over time (p < 0.01), and significantly increased area under the curve (AUC) for DAS28 (p < 0.05), ESR (p < 0.01), C-reactive protein (p < 0.01), and swollen joint count (p = 0.057) compared to those without. Corresponding differences were not found in patients with anti-CCP2, CCP3, and CCP3.1 antibodies. Radiological progression (p < 0.0001-0.01) and radiological outcome (p < 0.0001-0.01) at 24 months were significantly predicted by all ACPA after baseline adjustments. PTPN22 T variant and HLA-DRB1 alleles were not related to radiological progression or inflammatory activity over time.CONCLUSION: Anti-MCV antibodies are associated with a more severe RA disease, as measured by DAS28, ESR, and swollen joint count over time, compared with anti-CCP2, CCP3, and CCP3.1 antibodies. Radiological progression was predicted equally by all 4 autoantibodies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- anti-cyclic citrullinated peptide 2
- antibodies anti-cyclic citrullinated peptide 3 antibodies
- anti-mutated citrullinated vimentin antibodies
- early rheumatoid arthritis
- rheumatoid factors
Publication and Content Type
- ref (subject category)
- art (subject category)
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