Long-term exposure to particulate air pollution and presence and progression of carotid artery plaques: A northern Sweden VIPVIZA cohort study

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Nilsson Sommar, JohanUmeå universitet,Avdelningen för hållbar hälsa (author)

Long-term exposure to particulate air pollution and presence and progression of carotid artery plaques : A northern Sweden VIPVIZA cohort study

Article/chapterEnglish2022

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Elsevier,2022
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LIBRIS-ID:oai:DiVA.org:umu-192989
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-192989URI
https://doi.org/10.1016/j.envres.2022.113061DOI

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Language:English
Summary in:English

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AIMS: To estimate the association between long-term exposure to particulate air pollution and sub-clinical atherosclerosis based on the existence of plaque and the carotid intima-media thickness (cIMT).METHODS: Visualization of asymptomatic atherosclerotic disease for optimum cardiovascular prevention (VIPVIZA) is a randomised controlled trial integrated within the Västerbotten Intervention Programme, an ongoing population-based cardiovascular disease (CVD) prevention programme in northern Sweden. Individuals aged 40, 50, or 60 years with one or more conventional CVD risk factors in Umeå municipality were eligible to participate. The 1425 participants underwent an ultrasound assessment of cIMT and plaque formation during the period 2013-2016 and at 3-year follow-up. Source-specific annual mean concentrations of particulate matter with aerodynamic diameter ≤10 μm (PM10) and ≤2.5 μm (PM2.5), and black carbon (BC) at the individual's residential address were modelled for the calendar years 1990, 2001 and 2011. Poisson regression was used to estimate prevalence ratios for presence of carotid artery plaques, and linear regression for cIMT.RESULTS: The plaque prevalence was 43% at baseline and 47% at follow-up. An interquartile range (IQR) increase in PM10 (range in year 2011: 7.1-13.5 μg/m3) was associated with a prevalence ratio at baseline ultrasound of 1.11 (95% CI 0.99-1.25), 1.08 (95% CI 0.99-1.17), and 1.00 (95% CI 0.93-1.08) for lag 23, 12 and 2 years, and at follow-up 1.04 (95% CI 0.95-1.14), 1.08 (95% CI 1.00-1.16), and 1.01 (95% CI 0.95-1.08). Similar prevalence ratios per IQR were found for PM2.5 and BC, but with somewhat lower precision for the later. Particle concentrations were however not associated with the progression of plaque. No cross-sectional or longitudinal associations of change were found for cIMT.CONCLUSIONS: This study of individuals with low/moderate risk for CVD give some additional support for an effect of long-term air pollution in early subclinical atherosclerosis.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
Air pollution
Atherosclerosis
Carotid artery plaques
Carotid intima-media thickness
Cohort
Longitudinal

Added entries (persons, corporate bodies, meetings, titles ...)

Norberg, MargaretaUmeå universitet,Avdelningen för medicin(Swepub:umu)mano0062 (author)
Grönlund, ChristerUmeå universitet,Radiofysik(Swepub:umu)chgr0009 (author)
Segersson, DavidSwedish Meteorological and Hydrological Institute, Norrköping, Sweden. (author)
Näslund, UlfUmeå universitet,Avdelningen för medicin(Swepub:umu)ulna0002 (author)
Forsberg, Bertil,professor,1956-Umeå universitet,Avdelningen för hållbar hälsa(Swepub:umu)befo0001 (author)
Umeå universitetAvdelningen för hållbar hälsa (creator_code:org_t)

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In:Environmental Research: Elsevier2110013-93511096-0953

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