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Parvimonas micra is...
Parvimonas micra is associated with tumour immune profiles in molecular subtypes of colorectal cancer
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- Löwenmark, Thyra (author)
- Umeå universitet,Patologi
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- Li, Xingru (author)
- Umeå universitet,Patologi
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- Löfgren Burström, Anna (author)
- Umeå universitet,Patologi
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- Zingmark, Carl, 1975- (author)
- Umeå universitet,Patologi
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- Ling, Agnes (author)
- Umeå universitet,Patologi
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- Kellgren, Therese G. (author)
- Umeå universitet,Patologi,Avdelningen för medicin
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- Larsson, Pär (author)
- Umeå universitet,Patologi
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- Ljuslinder, Ingrid, 1968- (author)
- Umeå universitet,Onkologi
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- Wai, Sun Nyunt (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
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- Edin, Sofia (author)
- Umeå universitet,Patologi
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- Palmqvist, Richard (author)
- Umeå universitet,Patologi
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(creator_code:org_t)
- 2022-03-17
- 2022
- English.
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In: Cancer Immunology and Immunotherapy. - : Springer. - 0340-7004 .- 1432-0851. ; 71, s. 2565-2575
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Abstract
Subject headings
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- The importance of the tumour microbiome in different aspects of colorectal cancer (CRC) has been increasingly recognised, but many questions remain. The aim of this study was to explore the effect of specific CRC associated microbes on the tumour immune response, which has a considerable prognostic value in CRC. We applied specific qPCR to detect Parvimonas micra and Fusobacterium nucleatum in tumour tissues from an immunologically well-characterised cohort of 69 CRC patients. This cohort included detailed analyses of immune profiles based on flow cytometry and transcriptomics in tumour tissue and blood, along with comprehensive analyses of molecular subtypes. P. micra and F. nucleatum were detected in 24% and 64% of tumour tissues, respectively. We found a significant association of P. micra with high-grade tumours and tumours of CMS1 subtype. F. nucleatum was significantly associated with right-sided tumours, microsatellite instability, and CMS1 tumours. The immunological analyses revealed significant associations of P. micra with activated CD69+ T lymphocytes and increased antigen-presenting HLA-DR+ B lymphocytes. P. micra was also positively associated with M1 and M2 macrophage traits. The impact of P. micra tumour colonisation on the immune response was further assessed using transcriptomics in validation of our findings. No associations were found between F. nucleatum and immune profiles in this study. Our findings support novel associations between P. micra and the immune response in CRC. A better understanding of these interactions might help to identify important predictive and prognostic tools as well as new targets for therapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Colorectal cancer
- F. nucleatum
- Immunity
- Mucosal microbiota
- P. micra
Publication and Content Type
- ref (subject category)
- art (subject category)
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Löwenmark, Thyra
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Li, Xingru
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Löfgren Burström ...
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Zingmark, Carl, ...
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Ling, Agnes
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Kellgren, Theres ...
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Larsson, Pär
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Ljuslinder, Ingr ...
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Wai, Sun Nyunt
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Edin, Sofia
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Palmqvist, Richa ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Immunolog ...
- By the university
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Umeå University