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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03491naa a2200397 4500 | |
| 001 | oai:DiVA.org:umu-19407 | |
| 003 | SwePub | |
| 008 | 090305s2008 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:uu-211258 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-194072 URI |
| 024 | 7 | a https://doi.org/10.1016/j.abb.2008.02.0342 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2112582 URI |
| 040 | a (SwePub)umud (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Burén, Jonasu Umeå universitet,Medicin4 aut0 (Swepub:umu)jobu0003 |
| 245 | 1 0 | a Insulin action and signalling in fat and muscle from dexamethasone-treated rats |
| 264 | 1 | b Elsevier BV,c 2008 |
| 338 | a print2 rdacarrier | |
| 520 | a Glucocorticoids initiate whole body insulin resistance and the aim of the present study was to investigate effects of dexamethasone on protein expression and insulin signalling in muscle and fat tissue. Rats were injected with dexamethasone (1mg/kg/day, i.p.) or placebo for 11 days before insulin sensitivity was evaluated in vitro in soleus and epitrochlearis muscles and in isolated epididymal adipocytes. Dexamethasone treatment reduced insulin-stimulated glucose uptake and glycogen synthesis by 30-70% in epitrochlearis and soleus, and insulin-stimulated glucose uptake by approximately 40% in adipocytes. 8-bromo-cAMP-stimulated lipolysis was approximately 2-fold higher in adipocytes from dexamethasone-treated rats and insulin was less effective to inhibit cAMP-stimulated lipolysis. A main finding was that dexamethasone decreased expression of PKB and insulin-stimulated Ser(473) and Thr(308) phosphorylation in both muscles and adipocytes. Expression of GSK-3 was not influenced by dexamethasone treatment in muscles or adipocytes and insulin-stimulated GSK-3beta Ser(9) phosphorylation was reduced in muscles only. A novel finding was that glycogen synthase (GS) Ser(7) phosphorylation was higher in both muscles from dexamethasone-treated rats. GS expression decreased (by 50%) in adipocytes only. Basal and insulin-stimulated GS Ser(641) and GS Ser(645,649,653,657) phosphorylation was elevated in epitrochlearis and soleus muscles and GS fractional activity was reduced correspondingly. In conclusion, dexamethasone treatment (1) decreases PKB expression and insulin-stimulated phosphorylation in both muscles and adipocytes, and (2) increases GS phosphorylation (reduces GS fractional activity) in muscles and decreases GS expression in adipocytes. We suggest PKB and GS as major targets for dexamethasone-induced insulin resistance. | |
| 653 | a Lipolysis | |
| 653 | a Glycerol | |
| 653 | a cAMP | |
| 653 | a Glucocorticoids | |
| 653 | a Phosphorylation | |
| 700 | 1 | a Lai, Y C4 aut |
| 700 | 1 | a Lundgren, Magdalenau Umeå universitet,Medicin4 aut |
| 700 | 1 | a Eriksson, Jan Wu Umeå universitet,Medicin,Department of Public Health and Clinical Medicine, Umeå University Hospital, Umeå, Sweden4 aut0 (Swepub:uu)janer909 |
| 700 | 1 | a Jensen, J4 aut |
| 710 | 2 | a Umeå universitetb Medicin4 org |
| 773 | 0 | t Archives of Biochemistry and Biophysicsd : Elsevier BVg 474:1, s. 91-101q 474:1<91-101x 0003-9861x 1096-0384 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-19407 |
| 856 | 4 8 | u https://doi.org/10.1016/j.abb.2008.02.034 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-211258 |
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