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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 24485naa a2201861 4500 | |
| 001 | oai:DiVA.org:umu-194403 | |
| 003 | SwePub | |
| 008 | 220504s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1944032 URI |
| 024 | 7 | a https://doi.org/10.1126/scitranslmed.abj02642 DOI |
| 040 | a (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Hop, Paul J.u Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlands4 aut |
| 245 | 1 0 | a Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS |
| 264 | 1 | b American Association for the Advancement of Science,c 2022 |
| 338 | a print2 rdacarrier | |
| 520 | a Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an estimated heritability between 40 and 50%. DNA methylation patterns can serve as proxies of (past) exposures and disease progression, as well as providing a potential mechanism that mediates genetic or environmental risk. Here, we present a blood-based epigenome-wide association study meta-analysis in 9706 samples passing stringent quality control (6763 patients, 2943 controls). We identified a total of 45 differentially methylated positions (DMPs) annotated to 42 genes, which are enriched for pathways and traits related to metabolism, cholesterol biosynthesis, and immunity. We then tested 39 DNA methylation-based proxies of putative ALS risk factors and found that high-density lipoprotein cholesterol, body mass index, white blood cell proportions, and alcohol intake were independently associated with ALS. Integration of these results with our latest genome-wide association study showed that cholesterol biosynthesis was potentially causally related to ALS. Last, DNA methylation at several DMPs and blood cell proportion estimates derived from DNA methylation data were associated with survival rate in patients, suggesting that they might represent indicators of underlying disease processes potentially amenable to therapeutic interventions. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 653 | a Neurology | |
| 653 | a neurologi | |
| 700 | 1 | a Zwamborn, Ramona A.J.u Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlands4 aut |
| 700 | 1 | a Hannon, Eilisu University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter, United Kingdom4 aut |
| 700 | 1 | a Shireby, Gemma L.u University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter, United Kingdom4 aut |
| 700 | 1 | a Nabais, Marta F.u University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter, United Kingdom; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia4 aut |
| 700 | 1 | a Walker, Emma M.u University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter, United Kingdom4 aut |
| 700 | 1 | a van Rheenen, Wouteru Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlands4 aut |
| 700 | 1 | a van Vugt, Joke J.F.A.u Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlands4 aut |
| 700 | 1 | a Dekker, Annelot M.u Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlands4 aut |
| 700 | 1 | a Westeneng, Henk-Janu Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlands4 aut |
| 700 | 1 | a Tazelaar, Gijs H.P.u Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlands4 aut |
| 700 | 1 | a van Eijk, Kristel R.u Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlands4 aut |
| 700 | 1 | a Moisse, Matthieuu KU Leuven, University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), Leuven, Belgium; VIB, Center for Brain and Disease Research, Leuven, Belgium; University Hospitals Leuven, Department of Neurology, Leuven, Belgium4 aut |
| 700 | 1 | a Baird, Denisu Translational Biology, Biogen, MA, Boston, United States; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, University of Bristol, Bristol, United Kingdom4 aut |
| 700 | 1 | a Al Khleifat, Ahmadu Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom4 aut |
| 700 | 1 | a Iacoangeli, Alfredou Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; National Institute for Health Research Biomedical Research Centre, Dementia Unit, South London and Maudsley NHS Foundation Trust, King's College London, London, United Kingdom4 aut |
| 700 | 1 | a Ticozzi, Nicolau Department of Neurology-Stroke Unit, Laboratory of Neuroscience, Istituto Auxologico Italiano IRCCS, Milan, Italy; Department of Pathophysiology and Transplantation, “Dino Ferrari” Center, Università degli Studi di Milano, Milan, Italy4 aut |
| 700 | 1 | a Ratti, Antoniau Department of Neurology-Stroke Unit, Laboratory of Neuroscience, Istituto Auxologico Italiano IRCCS, Milan, Italy; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milano, Italy4 aut |
| 700 | 1 | a Cooper-Knock, Jonathanu Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, United Kingdom4 aut |
| 700 | 1 | a Morrison, Karen E.u School of Medicine, Dentistry, and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom4 aut |
| 700 | 1 | a Shaw, Pamela J.u Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, United Kingdom4 aut |
| 700 | 1 | a Basak, A. Nazliu Koc University, School of Medicine, Translational Medicine Research Center, NDAL, Istanbul, Turkey4 aut |
| 700 | 1 | a Chiò, Adrianou “Rita Levi Montalcini” Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy; Azienda Ospedaliero-Universitaria Città della Salute e della Scienza, SC Neurologia 1U, Turin, Italy4 aut |
| 700 | 1 | a Calvo, Andreau “Rita Levi Montalcini” Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy; Azienda Ospedaliero-Universitaria Città della Salute e della Scienza, SC Neurologia 1U, Turin, Italy4 aut |
| 700 | 1 | a Moglia, Cristinau “Rita Levi Montalcini” Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy; Azienda Ospedaliero-Universitaria Città della Salute e della Scienza, SC Neurologia 1U, Turin, Italy4 aut |
| 700 | 1 | a Canosa, Antoniou “Rita Levi Montalcini” Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy; Azienda Ospedaliero-Universitaria Città della Salute e della Scienza, SC Neurologia 1U, Turin, Italy4 aut |
| 700 | 1 | a Brunetti, Maurau “Rita Levi Montalcini” Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy4 aut |
| 700 | 1 | a Grassano, Mauriziou “Rita Levi Montalcini” Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy4 aut |
| 700 | 1 | a Gotkine, Marcu Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel; Agnes Ginges Center for Human Neurogenetics, Department of Neurology, Hadassah Medical Center, Jerusalem, Israel4 aut |
| 700 | 1 | a Lerner, Yossefu Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel; Agnes Ginges Center for Human Neurogenetics, Department of Neurology, Hadassah Medical Center, Jerusalem, Israel4 aut |
| 700 | 1 | a Zabari, Michalu Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel; Agnes Ginges Center for Human Neurogenetics, Department of Neurology, Hadassah Medical Center, Jerusalem, Israel4 aut |
| 700 | 1 | a Vourc'H, Patricku Service de Biochimie et Biologie moléculaire, CHU de Tours, Tours, France; UMR 1253, Université de Tours, Inserm, Tours, France4 aut |
| 700 | 1 | a Corcia, Philippeu UMR 1253, Université de Tours, Inserm, Tours, France; Centre de référence sur la SLA, CHU de Tours, Tours, France4 aut |
| 700 | 1 | a Couratier, Philippeu Centre de référence sur la SLA, CHRU de Limoges, Limoges, France; UMR 1094, Université de Limoges, Inserm, Limoges, France4 aut |
| 700 | 1 | a Mora Pardina, Jesus S.u ALS Unit, Hospital San Rafael, Madrid, Spain4 aut |
| 700 | 1 | a Salas, Teresau Department of Neurology, Hospital La Paz-Carlos III, Madrid, Spain4 aut |
| 700 | 1 | a Dion, Patricku Montréal Neurological Institute and Hospital, McGill University, QC, Montréal, Canada4 aut |
| 700 | 1 | a Ross, Jay P.u Montréal Neurological Institute and Hospital, McGill University, QC, Montréal, Canada; Department of Human Genetics, McGill University, QC, Montréal, Canada4 aut |
| 700 | 1 | a Henderson, Robert D.u Department of Neurology, Royal Brisbane and Women's Hospital, QLD, Brisbane, Australia4 aut |
| 700 | 1 | a Mathers, Susanu Calvary Health Care Bethlehem, VIC, Parkdale, Australia4 aut |
| 700 | 1 | a McCombe, Pamela A.u Centre for Clinical Research, University of Queensland, QLD, Brisbane, Australia4 aut |
| 700 | 1 | a Needham, Merrileeu Fiona Stanley Hospital, WA, Perth, Australia; Notre Dame University, WA, Fremantle, Australia; Institute for Immunology and Infectious Diseases, Murdoch University, WA, Perth, Australia4 aut |
| 700 | 1 | a Nicholson, Garthu ANZAC Research Institute, Concord Repatriation General Hospital, NSW, Sydney, Australia4 aut |
| 700 | 1 | a Rowe, Dominic B.u Centre for Motor Neuron Disease Research, Macquarie University, NSW, Australia4 aut |
| 700 | 1 | a Pamphlett, Rogeru Discipline of Pathology, Department of Neuropathology, Brain and Mind Centre, University of Sydney, NSW, Sydney, Australia4 aut |
| 700 | 1 | a Mather, Karen A.u Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, NSW, Sydney, Australia; Neuroscience Research Australia Institute, NSW, Randwick, Australia4 aut |
| 700 | 1 | a Sachdev, Perminder S.u Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, NSW, Sydney, Australia; Neuropsychiatric Institute, Prince of Wales Hospital, UNSW, NSW, Randwick, Australia4 aut |
| 700 | 1 | a Furlong, Sarahu Centre for Motor Neuron Disease Research, Macquarie University, NSW, Australia4 aut |
| 700 | 1 | a Garton, Fleur C.u Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia4 aut |
| 700 | 1 | a Henders, Anjali K.u Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia4 aut |
| 700 | 1 | a Lin, Tianu Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia4 aut |
| 700 | 1 | a Ngo, Shyuan T.u Centre for Clinical Research, University of Queensland, QLD, Brisbane, Australia; Australian Institute for Bioengineering and Nanotechnology, University of Queensland, QLD, Brisbane, Australia; Queensland Brain Institute, University of Queensland, QLD, Brisbane, Australia4 aut |
| 700 | 1 | a Steyn, Frederik J.u Centre for Clinical Research, University of Queensland, QLD, Brisbane, Australia; School of Biomedical Sciences, University of Queensland, QLD, Brisbane, Australia4 aut |
| 700 | 1 | a Wallace, Leanneu Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia4 aut |
| 700 | 1 | a Williams, Kelly L.u Centre for Motor Neuron Disease Research, Macquarie University, NSW, Australia4 aut |
| 700 | 1 | a Neto, Miguel Mitneu Universidade de São Paulo, São Paulo, Brazil4 aut |
| 700 | 1 | a Cauchi, Ruben J.u Center for Molecular Medicine and Biobanking, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta4 aut |
| 700 | 1 | a Blair, Ian P.u Centre for Motor Neuron Disease Research, Macquarie University, NSW, Australia4 aut |
| 700 | 1 | a Kiernan, Matthew C.u Brain and Mind Centre, University of Sydney, NSW, Sydney, Australia; Department of Neurology, Royal Prince Alfred Hospital, NSW, Sydney, Australia4 aut |
| 700 | 1 | a Drory, Vivianu Department of Neurology, Tel-Aviv Sourasky Medical Centre, Tel-Aviv, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel4 aut |
| 700 | 1 | a Povedano, Monicau Functional Unit of Amyotrophic Lateral Sclerosis (UFELA), Service of Neurology, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain4 aut |
| 700 | 1 | a de Carvalho, Mamedeu Instituto de Fisiologia, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal4 aut |
| 700 | 1 | a Pinto, Susanau Instituto de Fisiologia, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal4 aut |
| 700 | 1 | a Weber, Markusu Neuromuscular Diseases Unit, ALS Clinic, Kantonsspital St. Gallen, St. Gallen, Switzerland4 aut |
| 700 | 1 | a Rouleau, Guy A.u Montréal Neurological Institute and Hospital, McGill University, QC, Montréal, Canada4 aut |
| 700 | 1 | a Silani, Vincenzou Department of Neurology-Stroke Unit, Laboratory of Neuroscience, Istituto Auxologico Italiano IRCCS, Milan, Italy; Department of Pathophysiology and Transplantation, “Dino Ferrari” Center, Università degli Studi di Milano, Milan, Italy4 aut |
| 700 | 1 | a Landers, John E.u Department of Neurology, University of Massachusetts, Medical School, MA, Worcester, United States4 aut |
| 700 | 1 | a Shaw, Christopher E.u Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom4 aut |
| 700 | 1 | a Andersen, Peter M.,d 1962-u Umeå universitet,Neurovetenskaper4 aut0 (Swepub:umu)pean0001 |
| 700 | 1 | a McRae, Allan F.u Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia4 aut |
| 700 | 1 | a van Es, Michael A.u Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlands4 aut |
| 700 | 1 | a Pasterkamp, R. Jeroenu Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlands4 aut |
| 700 | 1 | a Wray, Naomi R.u Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia; Queensland Brain Institute, University of Queensland, QLD, Brisbane, Australia4 aut |
| 700 | 1 | a McLaughlin, Russell L.u Complex Trait Genomics Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland4 aut |
| 700 | 1 | a Hardiman, Orlau Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland4 aut |
| 700 | 1 | a Kenna, Kevin P.u Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlands; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlands4 aut |
| 700 | 1 | a Tsai, Ellenu Translational Biology, Biogen, MA, Boston, United States4 aut |
| 700 | 1 | a Runz, Heikou Translational Biology, Biogen, MA, Boston, United States4 aut |
| 700 | 1 | a Al-Chalabi, Ammaru Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; King's College Hospital, Denmark Hill, London, United Kingdom4 aut |
| 700 | 1 | a van den Berg, Leonard H.u Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlands4 aut |
| 700 | 1 | a Van Damme, Philipu KU Leuven, University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), Leuven, Belgium; VIB, Center for Brain and Disease Research, Leuven, Belgium; University Hospitals Leuven, Department of Neurology, Leuven, Belgium4 aut |
| 700 | 1 | a Mill, Jonathanu University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter, United Kingdom4 aut |
| 700 | 1 | a Veldink, Jan H.u Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlands4 aut |
| 700 | 1 | a Heijmans, Bastiaan T.u Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands4 aut |
| 700 | 1 | a t Hoen, Peter A.C.u Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands4 aut |
| 700 | 1 | a van Meurs, Joyceu Department of Internal Medicine, ErasmusMC, Rotterdam, Netherlands4 aut |
| 700 | 1 | a Jansen, Ricku Department of Psychiatry, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, Netherlands4 aut |
| 700 | 1 | a Franke, Ludeu Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, Netherlands4 aut |
| 700 | 1 | a Boomsma, Dorret I.u Depart-ment of Biological Psychology, VU University Amsterdam, Neuroscience Campus Amsterdam, Amsterdam, Netherlands4 aut |
| 700 | 1 | a Pool, Renéu Depart-ment of Biological Psychology, VU University Amsterdam, Neuroscience Campus Amsterdam, Amsterdam, Netherlands4 aut |
| 700 | 1 | a van Dongen, Jennyu Depart-ment of Biological Psychology, VU University Amsterdam, Neuroscience Campus Amsterdam, Amsterdam, Netherlands4 aut |
| 700 | 1 | a Hottenga, Joukje J.u Depart-ment of Biological Psychology, VU University Amsterdam, Neuroscience Campus Amsterdam, Amsterdam, Netherlands4 aut |
| 700 | 1 | a van Greevenbroek, Marleen M.J.u Department of Internal Medicine, School for Cardiovascular Diseases (CARIM), Maastricht University Medical Center, Maastricht, Netherlands4 aut |
| 700 | 1 | a Stehouwer, Coen D.A.u Department of Internal Medicine, School for Cardiovascular Diseases (CARIM), Maastricht University Medical Center, Maastricht, Netherlands4 aut |
| 700 | 1 | a van der Kallen, Carla J.H.u Department of Internal Medicine, School for Cardiovascular Diseases (CARIM), Maastricht University Medical Center, Maastricht, Netherlands4 aut |
| 700 | 1 | a Schalkwijk, Casper G.u Department of Internal Medicine, School for Cardiovascular Diseases (CARIM), Maastricht University Medical Center, Maastricht, Netherlands4 aut |
| 700 | 1 | a Wijmenga, Ciscau Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, Netherlands4 aut |
| 700 | 1 | a Zhernakova, Sashau Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, Netherlands4 aut |
| 700 | 1 | a Tigchelaar, Ettje F.u Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, Netherlands4 aut |
| 700 | 1 | a Slagboom, P. Elineu Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands4 aut |
| 700 | 1 | a Beekman, Marianu Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands4 aut |
| 700 | 1 | a Deelen, Jorisu Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands4 aut |
| 700 | 1 | a van Heemst, Dianau Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands4 aut |
| 700 | 1 | a van Duijn, Cornelia M.u Department of Genetic Epidemiology, ErasmusMC, Rotterdam, Netherlands4 aut |
| 700 | 1 | a Hofman, Bert A.u Department of Epidemiology, ErasmusMC, Rotterdam, Netherlands4 aut |
| 700 | 1 | a Isaacs, Aaronu Department of Genetic Epidemiology, ErasmusMC, Rotterdam, Netherlands4 aut |
| 700 | 1 | a Uitterlinden, André G.u Department of Internal Medicine, ErasmusMC, Rotterdam, Netherlands4 aut |
| 700 | 1 | a Jhamai, P. Milau Department of Internal Medicine, ErasmusMC, Rotterdam, Netherlands4 aut |
| 700 | 1 | a Verbiest, Michaelu Department of Internal Medicine, ErasmusMC, Rotterdam, Netherlands4 aut |
| 700 | 1 | a Suchiman, Eka H.D.u Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands4 aut |
| 700 | 1 | a Verkerk, Marijnu Department of Internal Medicine, ErasmusMC, Rotterdam, Netherlands4 aut |
| 700 | 1 | a van der Breggen, Ruudu Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands4 aut |
| 700 | 1 | a van Rooij, Jeroenu Department of Internal Medicine, ErasmusMC, Rotterdam, Netherlands4 aut |
| 700 | 1 | a Lakenberg, Nicou Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands4 aut |
| 700 | 1 | a Mei, Hailiangu Sequence Analysis Support Core, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands4 aut |
| 700 | 1 | a van Iterson, Maartenu Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands4 aut |
| 700 | 1 | a van Galen, Michielu Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands4 aut |
| 700 | 1 | a Bot, Janu SURFsara, Amsterdam, Netherlands4 aut |
| 700 | 1 | a van 'T Hof, Peteru Sequence Analysis Support Core, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands4 aut |
| 700 | 1 | a Nooren, Ireneu SURFsara, Amsterdam, Netherlands4 aut |
| 700 | 1 | a Moed, Matthijsu Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands4 aut |
| 700 | 1 | a Vermaat, Martijnu Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands4 aut |
| 700 | 1 | a Luijk, Renéu Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands4 aut |
| 700 | 1 | a Bonder, Marc Janu Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, Netherlands4 aut |
| 700 | 1 | a van Dijk, Freerku Genomics Coordination Center, University Medical Center Groningen, University of Groningen, Groningen, Netherlands4 aut |
| 700 | 1 | a Arindrarto, Wibowou Sequence Analysis Support Core, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands4 aut |
| 700 | 1 | a Kielbasa, Szymon M.u Medical Statistics, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands4 aut |
| 700 | 1 | a Swertz, Morris A.u Genomics Coordination Center, University Medical Center Groningen, University of Groningen, Groningen, Netherlands4 aut |
| 700 | 1 | a van Zwet, Erik W.u Medical Statistics, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands4 aut |
| 700 | 1 | a Bensimon, Gilbertu Queensland Brain Institute, University of Queensland, QLD, Brisbane, Australia; Département de Pharmacologie Clinique, Hôpital de la Pitié-Salpêtrière, UPMC Pharmacologie, AP-HP, Paris, France4 aut |
| 700 | 1 | a Smith, George Daveyu MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; Population Health Science, Bristol Medical School, Bristol, Bristol, United Kingdom4 aut |
| 710 | 2 | a Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlandsb University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter, United Kingdom4 org |
| 773 | 0 | t Science Translational Medicined : American Association for the Advancement of Scienceg 14:633q 14:633x 1946-6234x 1946-6242 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-194403 |
| 856 | 4 8 | u https://doi.org/10.1126/scitranslmed.abj0264 |
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