onr:"swepub:oai:DiVA.org:umu-19450"
Search: onr:"swepub:oai:DiVA.org:umu-19450" > TNFA -308G>A in two...
- 1 of 1
- Previous record
- Next record
- To hitlist
TNFA -308G>A in two international population-based cohorts and risk of asthma
- Castro-Giner, F (author)
- Kogevinas, M (author)
- Mächler, M (author)
- show more...
- de Cid, R (author)
- Van Steen, K (author)
- Imboden, M (author)
- Schindler, C (author)
- Berger, W (author)
- Gonzalez, J R (author)
- Janson, C (author)
- Jarvis, D (author)
- Omenaas, E (author)
- Burney, P (author)
- Rochat, T (author)
- Estivill, X (author)
- Antó, J M (author)
- Wjst, M (author)
- Probst-Hensch, N M (author)
- show less...
- (creator_code:org_t)
- 2008-03-19
- 2008
- English.
- In: European Respiratory Journal. - Sheffield : European respiratory society journals. - 0903-1936 .- 1399-3003. ; 32:2, s. 350-361
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Genetic association studies have related the tumour necrosis factor-alpha gene (TNFA) guanine to adenine substitution of nucleotide -308 (-308G>A) polymorphism to increased risk of asthma, but results are inconsistent. The aim of the present study was to test whether two single-nucleotide polymorphisms, of TNFA and of the lymphotoxin-alpha gene (LTA), are associated with asthma, bronchial hyperresponsiveness and atopy in adults, by combining the results of two large population-based multicentric studies and conducting a meta-analysis of previously published studies. The European Community Respiratory Health Survey (ECRHS) and Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) used comparable protocols, including questionnaires for respiratory symptoms and measures of lung function and atopy. DNA samples from 11,136 participants were genotyped at TNFA -308 and LTA 252. Logistic regression employing fixed and random effects models and nonparametric techniques were used. The prevalence of asthma was 6%. The TNFA -308G>A polymorphism was associated with increased asthma prevalence and with bronchial hyperresponsiveness. No consistent association was found for atopy. The LTA 252A>G polymorphism was not associated with any of the outcomes. A meta-analysis of 17 studies showed an increased asthma risk for the TNFA -308 adenine allele. The tumour necrosis factor-alpha gene nucleotide -308 polymorphism is associated with a moderately increased risk of asthma and bronchial hyperresponsiveness, but not with atopy. These results are supported by a meta-analysis of previously published studies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- asthma
- genetics
- lymphotoxin-alpha
- polymorphism
- tumour necrosis factor
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- European Respiratory Journal (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Castro-Giner, F
- Kogevinas, M
- Mächler, M
- de Cid, R
- Van Steen, K
- Imboden, M
- show more...
- Schindler, C
- Berger, W
- Gonzalez, J R
- Franklin, Karl A
- Janson, C
- Jarvis, D
- Omenaas, E
- Burney, P
- Rochat, T
- Estivill, X
- Antó, J M
- Wjst, M
- Probst-Hensch, N ...
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Respiratory Medi ...
- Articles in the publication
- European Respira ...
- By the university
- Umeå University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
